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rps24e rps24e rps27ae rps27ae rps27e rps27e rpl44e rpl44e rpl18a rpl18a eif6 eif6 rpl31e rpl31e rpl39e rpl39e dys dys tmcA tmcA rps6e rps6e eif2b eif2b rpl15e rpl15e infB infB AMM53747.1 AMM53747.1 AMM53751.1 AMM53751.1 rps8e rps8e rpl10e rpl10e AMM53855.1 AMM53855.1 AMM53980.1 AMM53980.1 proS proS AMM54018.1 AMM54018.1 eif2a eif2a rpl21e rpl21e AMM54115.1 AMM54115.1 rps3ae rps3ae rps15 rps15 AMM54207.1 AMM54207.1 flpA flpA csl4 csl4 AMM54236.1 AMM54236.1 ef1b ef1b secE secE rpl11 rpl11 rpl1 rpl1 rplP0 rplP0 rpl12p rpl12p rpl37ae rpl37ae AMM54287.1 AMM54287.1 srp19 srp19 rpl35ae rpl35ae AMM54378.1 AMM54378.1 rpl3 rpl3 rpl4lp rpl4lp rpl23 rpl23 rpl2p rpl2p rps19p rps19p rpl22 rpl22 rps3 rps3 rpl29 rpl29 AMM54409.1 AMM54409.1 rps17 rps17 rpl14 rpl14 rpl24p rpl24p rps4e rps4e rpl5 rpl5 rps14P rps14P rps8 rps8 rpl6 rpl6 rpl32e rpl32e rpl19e rpl19e rpl18 rpl18 rps5 rps5 rpl30p rpl30p rpl15 rpl15 secY secY eif2g eif2g srp54 srp54 gltX gltX ftsY ftsY AMM54533.1 AMM54533.1 rps13 rps13 rps4 rps4 rps11 rps11 rpl18e rpl18e rpl13 rpl13 rps9 rps9 rps2 rps2 prf1 prf1 eif1a eif1a AMM54608.1 AMM54608.1 psmA psmA AMM54621.1 AMM54621.1 rrp4 rrp4 rrp41 rrp41 rrp42 rrp42 rpl30e rpl30e rps12 rps12 rps7 rps7 nac nac AMM54655.1 AMM54655.1 rpl37e rpl37e rpl7ae rpl7ae rps28e rps28e rpl24e rpl24e tuf tuf rps10p rps10p pelA pelA rpl40e rpl40e rps17e rps17e AMM54819.1 AMM54819.1 rps19e rps19e nep1 nep1 eif5a eif5a rpl34e rpl34e rpl14e rpl14e
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rps24e30S ribosomal protein S24; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS24 family. (100 aa)
rps27ae30S ribosomal protein S27; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS31 family. (50 aa)
rps27e30S ribosomal protein S27; Although this protein has a potential zinc-binding site from the CXXC motifs, there is no experimental evidence that it binds zinc; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
rpl44e50S ribosomal protein L44; Binds to the 23S rRNA. (94 aa)
rpl18a50S ribosomal protein LX; Derived by automated computational analysis using gene prediction method: Protein Homology. (77 aa)
eif6Translation initiation factor 6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (227 aa)
rpl31e50S ribosomal protein L31; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribosomal protein L31e family. (94 aa)
rpl39e50S ribosomal protein L39; Part of the polypeptide exit tunnel in the 50S ribosomal complex; Derived by automated computational analysis using gene prediction method: Protein Homology. (51 aa)
dysDeoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. (336 aa)
tmcAtRNA(Met) cytidine acetyltransferase; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (816 aa)
rps6e30S ribosomal protein S6; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS6 family. (125 aa)
eif2bTranslation initiation factor IF-2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (140 aa)
rpl15e50S ribosomal protein L15e; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eL15 family. (194 aa)
infBTranslation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (587 aa)
AMM53747.1Fmu (Sun) domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (451 aa)
AMM53751.1ATPase; Originally found to be an inhibitor of the antiviral RNase-L in human cells; contains ABC-type nucleotide binding domains; putatively functions in RNA maturation; Derived by automated computational analysis using gene prediction method: Protein Homology. (589 aa)
rps8e30S ribosomal protein S8e; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
rpl10e50S ribosomal protein L10e; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uL16 family. (181 aa)
AMM53855.1LSU ribosomal protein L41E; Derived by automated computational analysis using gene prediction method: Protein Homology. (37 aa)
AMM53980.1Nonsense-mediated mRNA decay NMD3 like protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
proSprolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (482 aa)
AMM54018.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PDCD5 family. (112 aa)
eif2aTranslation initiation factor IF-2 subunit alpha; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (275 aa)
rpl21e50S ribosomal protein L21; Mediates an interaction between 5S and domains II and V of 23S; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eL21 family. (97 aa)
AMM54115.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
rps3ae30S ribosomal protein S3Ae; The function for this protein is unknown; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS1 family. (199 aa)
rps1530S ribosomal protein S15; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
AMM54207.1C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; Functions along with aFIB and aL7a; guides 2'-O-methylation of ribose to specific sites in RNAs; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
flpAFibrillin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (227 aa)
csl4RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. (198 aa)
AMM54236.1RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (63 aa)
ef1bEffector protein; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (91 aa)
secEPreprotein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (61 aa)
rpl1150S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (164 aa)
rpl150S ribosomal protein L1; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (216 aa)
rplP0Acidic ribosomal protein P0; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (341 aa)
rpl12p50S ribosomal protein L12; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (107 aa)
rpl37ae50S ribosomal protein L37; Binds to the 23S rRNA. (83 aa)
AMM54287.1Ribosomal biogenesis protein; Probably involved in the biogenesis of the ribosome. (223 aa)
srp19Signal recognition particle; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. (100 aa)
rpl35ae50S ribosomal protein L35; The function of this ribosomal subunit is unknown; Derived by automated computational analysis using gene prediction method: Protein Homology. (87 aa)
AMM54378.1TATA box-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (441 aa)
rpl350S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (359 aa)
rpl4lp50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (255 aa)
rpl2350S ribosomal protein L23; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa)
rpl2p50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (239 aa)
rps19p30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (132 aa)
rpl2250S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (155 aa)
rps330S ribosomal protein S3; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (209 aa)
rpl2950S ribosomal protein L29; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uL29 family. (68 aa)
AMM54409.1Protein translation factor SUI1; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SUI1 family. (98 aa)
rps1730S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (113 aa)
rpl1450S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (141 aa)
rpl24p50S ribosomal protein L24; Located at the polypeptide exit tunnel on the outside of the subunit. (121 aa)
rps4e30S ribosomal protein S4e; The function of this ribosomal subunit is unknown; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
rpl550S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (186 aa)
rps14P30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles. (56 aa)
rps830S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rpl650S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (184 aa)
rpl32e50S ribosomal protein L32; Contacts helix 25 of domain II of the 23S rRNA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eL32 family. (130 aa)
rpl19e50S ribosomal protein L19; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (150 aa)
rpl1850S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (203 aa)
rps530S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy. (236 aa)
rpl30p50S ribosomal protein L30; L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
rpl1550S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (147 aa)
secYPreprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (468 aa)
eif2gTranslation initiation factor IF-2 subunit gamma; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (411 aa)
srp54Signal recognition particle; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (443 aa)
gltXglutamyl-tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (572 aa)
ftsYCell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (322 aa)
AMM54533.116S rRNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
rps1330S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (148 aa)
rps430S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (180 aa)
rps1130S ribosomal protein S11; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (137 aa)
rpl18e50S ribosomal protein L18e; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eL18 family. (120 aa)
rpl1350S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
rps930S ribosomal protein S9; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS9 family. (135 aa)
rps230S ribosomal protein S2; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS2 family. (202 aa)
prf1Peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (414 aa)
eif1aTranslation initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (113 aa)
AMM54608.1RNA-processing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
psmAProteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (260 aa)
AMM54621.1Shwachman#Bodian#Diamond syndrome protein family; SBDS; similar to eukaryotic proteins involved in RNA metabolism or binding; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
rrp4RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. (261 aa)
rrp41Exonuclease; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails. (249 aa)
rrp42RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. (276 aa)
rpl30e50S ribosomal protein L30; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eL30 family. (99 aa)
rps1230S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (147 aa)
rps730S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (215 aa)
nacNascent polypeptide-associated complex protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. (109 aa)
AMM54655.1Small nuclear ribonucleoprotein; Enables 3` processing of polyadenylated mRNAs and tRNA precursors; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the snRNP Sm proteins family. (76 aa)
rpl37e50S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (62 aa)
rpl7ae50S ribosomal protein L7; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (123 aa)
rps28e30S ribosomal protein S28; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS28 family. (71 aa)
rpl24e50S ribosomal protein L24; Binds to the 23S rRNA. (67 aa)
tufElongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (428 aa)
rps10p30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
pelAmRNA surveillance protein Pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. (356 aa)
rpl40e50S ribosomal protein L40; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eL40 family. (51 aa)
rps17e30S ribosomal protein S17e; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS17 family. (67 aa)
AMM54819.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
rps19e30S ribosomal protein S19; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (150 aa)
nep116S rRNA methyltransferase; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (224 aa)
eif5aTranslation initiation factor IF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (138 aa)
rpl34e50S ribosomal protein L34; The function of this protein in the ribosome is unknown; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eL34 family. (90 aa)
rpl14e50S ribosomal protein L14e; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eL14 family. (83 aa)
Your Current Organism:
Pyrococcus kukulkanii
NCBI taxonomy Id: 1609559
Other names: DSM 101590, P. kukulkanii, Pyrococcus kukulkanii Callac et al. 2016, Pyrococcus sp. NCB100, Souchotheque de Bretagne BG1337, strain NCB100
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