STRINGSTRING
AMM53755.1 AMM53755.1 speH speH moaA moaA AMM53117.1 AMM53117.1 nnrD nnrD endA endA AMM53270.1 AMM53270.1 AMM53273.1 AMM53273.1 AMM53274.1 AMM53274.1 eno eno pckG pckG cobD cobD dacZ dacZ AMM53466.1 AMM53466.1 pyrF pyrF fbp fbp purK purK AMM53730.1 AMM53730.1 AMM53748.1 AMM53748.1 pdxS pdxS pdxT pdxT AMM54775.1 AMM54775.1 AMM54754.1 AMM54754.1 hycE hycE AMM54743.1 AMM54743.1 nth nth thiC thiC trpB trpB pdaD pdaD AMM54545.1 AMM54545.1 AMM54543.1 AMM54543.1 AMM54496.1 AMM54496.1 AMM54495.1 AMM54495.1 taw1 taw1 moaC moaC AMM54366.1 AMM54366.1 AMM54133.1 AMM54133.1 AMM54130.1 AMM54130.1 mfnA mfnA rbcL rbcL AMM54022.1 AMM54022.1 AMM53946.1 AMM53946.1 AMM53945.1 AMM53945.1 AMM53937.1 AMM53937.1 AMM53921.1 AMM53921.1 queE queE AMM53848.1 AMM53848.1 AMM53834.1 AMM53834.1 AMM53771.1 AMM53771.1 AMM53764.1 AMM53764.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AMM53755.1glutaconyl-CoA decarboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
speHS-adenosylmethionine decarboxylase; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (140 aa)
moaAMolybdenum cofactor biosynthesis protein MoeA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (306 aa)
AMM53117.1Fuculose phosphate aldolase; Catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
nnrDCarbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] (480 aa)
endARibonuclease BN; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (170 aa)
AMM53270.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
AMM53273.1Fe-S cluster assembly protein HesB; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
AMM53274.16-carboxy-5,6,7,8-tetrahydropterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (151 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (624 aa)
cobDCobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (294 aa)
dacZHypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. (268 aa)
AMM53466.1Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (211 aa)
fbpFructose 1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (375 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (373 aa)
AMM53730.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
AMM53748.1Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (450 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (328 aa)
pdxTGlutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (196 aa)
AMM54775.1Phosphopantothenoylcysteine decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
AMM54754.1Subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology. (521 aa)
hycEHydrogenase 3 large subunit; Formate hydrogenlyase subunit 5; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. (566 aa)
AMM54743.1Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (215 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (425 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (443 aa)
pdaDPyruvoyl-dependent arginine decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PdaD family. (158 aa)
AMM54545.1Threonine synthase; Catalyzes the formation of L-threonine from O-phospho-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
AMM54543.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
AMM54496.1Fumarate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
AMM54495.1Fumarate hydratase; Catalyzes the reversible hydration of fumaric acid to yield l-malic acid; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
taw1tRNA-modifying protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (338 aa)
moaCMolybdenum cofactor biosynthesis protein MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (158 aa)
AMM54366.1Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
AMM54133.1Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
AMM54130.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
mfnAL-tyrosine decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (382 aa)
rbcLRibulose 1,5-bisphosphate carboxylase; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (420 aa)
AMM54022.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
AMM53946.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
AMM53945.1Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
AMM53937.1Subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology. (486 aa)
AMM53921.1N-glycosylase; DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double- stranded DNA substrates. (239 aa)
queE7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (253 aa)
AMM53848.16-pyruvoyl tetrahydropterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (115 aa)
AMM53834.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
AMM53771.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
AMM53764.1Lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
Your Current Organism:
Pyrococcus kukulkanii
NCBI taxonomy Id: 1609559
Other names: DSM 101590, P. kukulkanii, Pyrococcus kukulkanii Callac et al. 2016, Pyrococcus sp. NCB100, Souchotheque de Bretagne BG1337, strain NCB100
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.