(6 nodes) De novo pyrimidine nucleobase biosynthetic process network (Methanobrevibacter sp. YE315)

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second shell of interactors

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experimentally determined

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gene fusions

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protein homology

Your Input:
	pyrD	Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (303 aa)
	pyrB	Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
	carA	Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
	pyrF	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (215 aa)
	pyrI	Aspartate carbamoyltransferase; Involved in allosteric regulation of aspartate carbamoyltransferase. (159 aa)
	fae-hps	Bifunctional formaldehyde-activating protein/3-hexulose-6-phosphate synthase; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (413 aa)

Your Current Organism:

Methanobrevibacter sp. YE315

NCBI taxonomy Id: 1609968
Other names: M. sp. YE315

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
carA	pyrB	TL18_02395	TL18_00125	Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
carA	pyrD	TL18_02395	TL18_09465	Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.	0.999
carA	pyrF	TL18_02395	TL18_03990	Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology.	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	0.999
carA	pyrI	TL18_02395	TL18_08115	Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aspartate carbamoyltransferase; Involved in allosteric regulation of aspartate carbamoyltransferase.	0.970
pyrB	carA	TL18_00125	TL18_02395	Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
pyrB	pyrD	TL18_00125	TL18_09465	Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.	0.999
pyrB	pyrF	TL18_00125	TL18_03990	Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	0.999
pyrB	pyrI	TL18_00125	TL18_08115	Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aspartate carbamoyltransferase; Involved in allosteric regulation of aspartate carbamoyltransferase.	0.999
pyrD	carA	TL18_09465	TL18_02395	Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.	Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
pyrD	pyrB	TL18_09465	TL18_00125	Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.	Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
pyrD	pyrF	TL18_09465	TL18_03990	Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	0.999
pyrD	pyrI	TL18_09465	TL18_08115	Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.	Aspartate carbamoyltransferase; Involved in allosteric regulation of aspartate carbamoyltransferase.	0.762
pyrF	carA	TL18_03990	TL18_02395	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
pyrF	pyrB	TL18_03990	TL18_00125	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
pyrF	pyrD	TL18_03990	TL18_09465	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.	0.999
pyrF	pyrI	TL18_03990	TL18_08115	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	Aspartate carbamoyltransferase; Involved in allosteric regulation of aspartate carbamoyltransferase.	0.919
pyrI	carA	TL18_08115	TL18_02395	Aspartate carbamoyltransferase; Involved in allosteric regulation of aspartate carbamoyltransferase.	Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.970
pyrI	pyrB	TL18_08115	TL18_00125	Aspartate carbamoyltransferase; Involved in allosteric regulation of aspartate carbamoyltransferase.	Aspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
pyrI	pyrD	TL18_08115	TL18_09465	Aspartate carbamoyltransferase; Involved in allosteric regulation of aspartate carbamoyltransferase.	Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.	0.762
pyrI	pyrF	TL18_08115	TL18_03990	Aspartate carbamoyltransferase; Involved in allosteric regulation of aspartate carbamoyltransferase.	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	0.919