STRINGSTRING
pyrH pyrH AMD17056.1 AMD17056.1 AMD17088.1 AMD17088.1 argB argB AMD17106.1 AMD17106.1 AMD17116.1 AMD17116.1 AMD17170.1 AMD17170.1 AMD17179.1 AMD17179.1 prs prs AMD17235.1 AMD17235.1 AMD17243.1 AMD17243.1 AMD17276.1 AMD17276.1 AMD17298.1 AMD17298.1 AMD17307.1 AMD17307.1 AMD17392.1 AMD17392.1 AMD17393.1 AMD17393.1 AMD17394.1 AMD17394.1 cca cca AMD17495.1 AMD17495.1 AMD17501.1 AMD17501.1 priL priL priS priS AMD17509.1 AMD17509.1 AMD17554.1 AMD17554.1 AMD17619.1 AMD17619.1 AMD17621.1 AMD17621.1 ndk ndk mobA mobA cofC cofC AMD17690.1 AMD17690.1 thiI-2 thiI-2 AMD17758.1 AMD17758.1 AMD17762.1 AMD17762.1 AMD17784.1 AMD17784.1 AMD17788.1 AMD17788.1 AMD17812.1 AMD17812.1 AMD17833.1 AMD17833.1 mvk mvk rpoK rpoK AMD17840.1 AMD17840.1 rpoD rpoD cmk cmk adkA adkA coaD coaD pgk2 pgk2 AMD17931.1 AMD17931.1 AMD17944.1 AMD17944.1 aroK aroK carS carS ribL ribL nadK nadK rpoA2 rpoA2 AMD18094.1 AMD18094.1 AMD18095.1 AMD18095.1 AMD18096.1 AMD18096.1 rpoH rpoH thiM thiM pgk pgk cobS cobS AMD18138.1 AMD18138.1 cofD cofD AMD18171.1 AMD18171.1 AMD18176.1 AMD18176.1 AMD18187.1 AMD18187.1 AMD18222.1 AMD18222.1 AMD18239.1 AMD18239.1 AMD18488.1 AMD18488.1 AMD18319.1 AMD18319.1 AMD18355.1 AMD18355.1 thiL thiL AMD16614.1 AMD16614.1 AMD16619.1 AMD16619.1 AMD16670.1 AMD16670.1 polC polC AMD16714.1 AMD16714.1 AMD16760.1 AMD16760.1 AMD16788.1 AMD16788.1 mptE mptE dnaG dnaG AMD16804.1 AMD16804.1 thiI thiI AMD16839.1 AMD16839.1 AMD16844.1 AMD16844.1 AMD18416.1 AMD18416.1 AMD16899.1 AMD16899.1 AMD16918.1 AMD16918.1 AMD16941.1 AMD16941.1 AMD16943.1 AMD16943.1 tmk tmk AMD16992.1 AMD16992.1 AMD17007.1 AMD17007.1 ribK ribK polB polB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (225 aa)
AMD17056.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
AMD17088.12-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (287 aa)
AMD17106.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
AMD17116.1phospho-N-acetylmuramoyl-pentapeptide- transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
AMD17170.1Ribokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. (311 aa)
AMD17179.1Phosphatidate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (304 aa)
AMD17235.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
AMD17243.1UTP--glucose-1-phosphate uridylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
AMD17276.1Ribokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
AMD17298.1Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
AMD17307.1DNA-directed RNA polymerase subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (105 aa)
AMD17392.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
AMD17393.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (795 aa)
AMD17394.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (794 aa)
ccatRNA CCA-pyrophosphorylase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (454 aa)
AMD17495.1GHMP kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
AMD17501.1Multidrug transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
priLDNA primase; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (442 aa)
priSDNA primase; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play [...] (325 aa)
AMD17509.1Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
AMD17554.1Nicotinamide-nucleotide adenylyltransferase; Catalyzes the formation of NAD+ from nicotinamide ribonucleotide and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
AMD17619.1Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (169 aa)
AMD17621.1DNA-directed RNA polymerase subunit E; Participates in both the initiation and recycling phases of transcription; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (150 aa)
mobAMolybdopterin-guanine dinucleotide biosynthesis protein MobA; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (209 aa)
cofC2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (223 aa)
AMD17690.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
thiI-2tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (383 aa)
AMD17758.1Glycerol-3-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
AMD17762.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
AMD17784.1DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)
AMD17788.1triphosphoribosyl-dephospho-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
AMD17812.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (467 aa)
AMD17833.1Amino acid kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (266 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (320 aa)
rpoKDNA-directed RNA polymerase subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (60 aa)
AMD17840.1DNA-directed RNA polymerase subunit N; Derived by automated computational analysis using gene prediction method: Protein Homology. (56 aa)
rpoDDNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (267 aa)
cmkCytidylate kinase; Catalyzes the formation of (d)CDP from ATP and (d)CMP; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
adkAAdenylate kinase; Catalyzes the formation of 2 ADP from AMP and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the archaeal adenylate kinase family. (186 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the eukaryotic CoaD family. (152 aa)
pgk22-phosphoglycerate kinase; Catalyzes the formation of 2-phospho-D-glyceroyl phosphate from ATP and 2-phospho-D-glycerate; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
AMD17931.1Molybdopterin adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (168 aa)
AMD17944.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (406 aa)
aroKShikimate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
carSHypothetical protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (188 aa)
ribLFAD synthase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (150 aa)
nadKInorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (619 aa)
rpoA2DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (397 aa)
AMD18094.1DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (921 aa)
AMD18095.1DNA-directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (601 aa)
AMD18096.1DNA-directed RNA polymerase subunit B'; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (514 aa)
rpoHDNA-directed RNA polymerase subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (77 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (288 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (404 aa)
cobSCobalamin biosynthesis protein CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (260 aa)
AMD18138.1Serine/threonine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
cofDLPPG:FO 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (301 aa)
AMD18171.1Phosphatidylserine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
AMD18176.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (758 aa)
AMD18187.1Cobalamin biosynthesis protein CobY; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
AMD18222.1DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (595 aa)
AMD18239.1DNA polymerase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
AMD18488.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (829 aa)
AMD18319.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (454 aa)
AMD18355.1Serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. (529 aa)
thiLThiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (308 aa)
AMD16614.1Glucose-1-phosphate thymidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
AMD16619.1CDP-glycerol:glycerophosphate glycerophosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
AMD16670.1DNA-directed RNA polymerase subunit L; Derived by automated computational analysis using gene prediction method: Protein Homology. (92 aa)
polCDNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1099 aa)
AMD16714.1Sugar kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. (304 aa)
AMD16760.1ATPase AAA; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (181 aa)
AMD16788.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
mptE6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (239 aa)
dnaGHypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (414 aa)
AMD16804.1Glucose-1-phosphate thymidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
thiItRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (384 aa)
AMD16839.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (538 aa)
AMD16844.1Phosphatidylglycerophosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (189 aa)
AMD18416.1Delta 1-pyrroline-5-carboxylate synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
AMD16899.1Secretion protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
AMD16918.1Phosphoenolpyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (879 aa)
AMD16941.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (528 aa)
AMD16943.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (553 aa)
tmkThymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
AMD16992.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (531 aa)
AMD17007.1Guanylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
ribKRiboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (124 aa)
polBDNA polymerase II; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (556 aa)
Your Current Organism:
Methanobrevibacter sp. YE315
NCBI taxonomy Id: 1609968
Other names: M. sp. YE315
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