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dadD dadD AMD16660.1 AMD16660.1 AMD16737.1 AMD16737.1 AMD16802.1 AMD16802.1 AMD16962.1 AMD16962.1 AMD16976.1 AMD16976.1 dcd dcd pyrC pyrC mptA mptA AMD18315.1 AMD18315.1 hisH hisH AMD18496.1 AMD18496.1 nadE nadE hisI hisI purO purO gch3 gch3 AMD18056.1 AMD18056.1 ade ade purQ purQ AMD17594.1 AMD17594.1 pyrG pyrG AMD17329.1 AMD17329.1 mch mch gatD gatD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dadDN-ethylammeline chlorohydrolase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon the [...] (434 aa)
AMD16660.1Competence protein TfoX; Derived by automated computational analysis using gene prediction method: Protein Homology. (84 aa)
AMD16737.1Protein fwdA; Derived by automated computational analysis using gene prediction method: Protein Homology. (571 aa)
AMD16802.1Competence protein TfoX; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
AMD16962.1Carbon-nitrogen hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
AMD16976.1Chlorohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
dcdDeoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (194 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (418 aa)
mptAGTP cyclohydrolase; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (313 aa)
AMD18315.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
hisHImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (198 aa)
AMD18496.1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
nadENAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (262 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (135 aa)
purOIMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (208 aa)
gch3GTP cyclohydrolase; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family. (253 aa)
AMD18056.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the arginase family. (288 aa)
adeAdenine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (572 aa)
purQPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (214 aa)
AMD17594.1Creatinine amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (538 aa)
AMD17329.1Choloylglycine hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
mchN(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (323 aa)
gatDglutamyl-tRNA amidotransferase; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (436 aa)
Your Current Organism:
Methanobrevibacter sp. YE315
NCBI taxonomy Id: 1609968
Other names: M. sp. YE315
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