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AMD17165.1 AMD17165.1 trpB trpB AMD16561.1 AMD16561.1 AMD16571.1 AMD16571.1 cobD cobD AMD16585.1 AMD16585.1 AMD16594.1 AMD16594.1 cbiX cbiX AMD16598.1 AMD16598.1 leuD leuD leuC leuC AMD16616.1 AMD16616.1 moaC moaC hisF hisF lysA lysA thiC thiC moaA moaA AMD16751.1 AMD16751.1 leuC-2 leuC-2 AMD16754.1 AMD16754.1 thiC-2 thiC-2 fbp fbp AMD16919.1 AMD16919.1 AMD16921.1 AMD16921.1 AMD16961.1 AMD16961.1 AMD17016.1 AMD17016.1 AMD17018.1 AMD17018.1 AMD17105.1 AMD17105.1 AMD17166.1 AMD17166.1 pyrF pyrF mfnB mfnB AMD17465.1 AMD17465.1 aroB aroB aroA aroA AMD17511.1 AMD17511.1 AMD17512.1 AMD17512.1 AMD17518.1 AMD17518.1 AMD17563.1 AMD17563.1 argH argH AMD17631.1 AMD17631.1 AMD17634.1 AMD17634.1 aroD aroD nth nth AMD17682.1 AMD17682.1 AMD17771.1 AMD17771.1 AMD17786.1 AMD17786.1 AMD17789.1 AMD17789.1 aroC aroC eno eno AMD17887.1 AMD17887.1 dapA dapA deoC deoC hacB hacB pdaD pdaD taw1 taw1 AMD18107.1 AMD18107.1 AMD18113.1 AMD18113.1 AMD18120.1 AMD18120.1 AMD18479.1 AMD18479.1 mptD mptD mfnA mfnA cofG cofG AMD18229.1 AMD18229.1 AMD18230.1 AMD18230.1 AMD18233.1 AMD18233.1 queE queE AMD18237.1 AMD18237.1 AMD18245.1 AMD18245.1 nnrD nnrD trpA trpA trpB-2 trpB-2 AMD18306.1 AMD18306.1 AMD18308.1 AMD18308.1 AMD18309.1 AMD18309.1 AMD18313.1 AMD18313.1 hisH hisH hisB hisB fae-hps fae-hps AMD18382.1 AMD18382.1 ilvD ilvD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AMD17165.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (433 aa)
AMD16561.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
AMD16571.13,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (227 aa)
cobDCobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (345 aa)
AMD16585.1Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
AMD16594.1Sirohydrochlorin cobaltochelatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
cbiXSirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (165 aa)
AMD16598.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
leuD3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (159 aa)
leuC3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (414 aa)
AMD16616.1Spore coat protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
moaCMolybdenum cofactor biosynthesis protein MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (155 aa)
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (274 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (427 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (432 aa)
moaAMolybdenum cofactor biosynthesis protein MoeA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (309 aa)
AMD16751.1UbiC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
leuC-23-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (417 aa)
AMD16754.1Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
thiC-2Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (424 aa)
fbpFructose 1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (365 aa)
AMD16919.1Fumarate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
AMD16921.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
AMD16961.1Phycocyanin alpha phycocyanobilin lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
AMD17016.12-methylcitrate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
AMD17018.1Fumarate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
AMD17105.1PBS lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
AMD17166.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the complex I 49 kDa subunit family. (374 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (215 aa)
mfnBHypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). (237 aa)
AMD17465.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
aroB3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (376 aa)
aroAFructose-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (263 aa)
AMD17511.1Sulfopyruvate decarboxylase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
AMD17512.1Sulfopyruvate decarboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
AMD17518.1Phosphosulfolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
AMD17563.1Flagellar protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
argHArgininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
AMD17631.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (398 aa)
AMD17634.1Ribonuclease BN; Derived by automated computational analysis using gene prediction method: Protein Homology. (171 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (224 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (214 aa)
AMD17682.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
AMD17771.1uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
AMD17786.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
AMD17789.1Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (333 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (364 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (414 aa)
AMD17887.1Fumarate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (242 aa)
hacB3-isopropylmalate dehydratase; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD family. LeuD ty [...] (160 aa)
pdaDPyruvoyl-dependent arginine decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PdaD family. (153 aa)
taw1tRNA-modifying enzyme; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (305 aa)
AMD18107.1Fumarate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
AMD18113.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LarC family. (389 aa)
AMD18120.1Pyruvate carboxylase subunit B; Catalyzes the formation of oxaloacetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (570 aa)
AMD18479.1Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
mptDDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. (123 aa)
mfnAL-tyrosine decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (385 aa)
cofGFO synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (363 aa)
AMD18229.1Phosphopantothenoylcysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
AMD18230.1Phosphopantothenoylcysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
AMD18233.1Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
queERadical SAM protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (232 aa)
AMD18237.16-carboxy-5,6,7,8-tetrahydropterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (171 aa)
AMD18245.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
nnrDSugar kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of [...] (513 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa)
trpB-2Phosphoribosylanthranilate isomerase; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa)
AMD18306.1Indole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
AMD18308.1Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
AMD18309.1Anthranilate synthase subunit I; Derived by automated computational analysis using gene prediction method: Protein Homology. (498 aa)
AMD18313.1Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (449 aa)
hisHImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (198 aa)
hisBImidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
fae-hpsBifunctional formaldehyde-activating protein/3-hexulose-6-phosphate synthase; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (413 aa)
AMD18382.1Carbonic anhydrase; Derived by automated computational analysis using gene prediction method: Protein Homology. (175 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (549 aa)
Your Current Organism:
Methanobrevibacter sp. YE315
NCBI taxonomy Id: 1609968
Other names: M. sp. YE315
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