(42 nodes) Monocarboxylic acid metabolic process network (Methanobrevibacter sp. YE315)

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	AMD16751.1	UbiC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
	AMD16788.1	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
	apgM	Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (412 aa)
	AMD16855.1	Biotin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
	AMD16918.1	Phosphoenolpyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (879 aa)
	AMD16922.1	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
	porA	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
	AMD18423.1	Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (80 aa)
	AMD16924.1	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
	AMD17003.1	Lactaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (470 aa)
	AMD17016.1	2-methylcitrate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
	AMD17068.1	Indolepyruvate oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
	AMD17071.1	phenylacetate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
	AMD17106.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
	AMD17147.1	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (554 aa)
	AMD17264.1	(4Fe-4S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
	AMD17304.1	phenylacetate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
	AMD17476.1	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (314 aa)
	cpgS	2,3-diphosphoglycerate synthetase; Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP. (459 aa)
	AMD17575.1	Phosphoglycerate mutase; Catalyzes the interconversion of 3-phosphoglycerate and 2-phosphoglycerate; this enzyme does not require the cofactor 2,3-bisphosphoglycerate as a phosphate donor; BPG-independent PGAM; aPGAM; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
	AMD17594.1	Creatinine amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
	cofC	2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (223 aa)
	AMD17699.1	Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
	AMD17743.1	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
	AMD17811.1	F420-0--gamma-glutamyl ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
	AMD17812.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (467 aa)
	eno	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (414 aa)
	AMD17912.1	3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
	AMD17935.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
	hacB	3-isopropylmalate dehydratase; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD family. LeuD ty [...] (160 aa)
	pgk	Phosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (404 aa)
	tpiA	Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (222 aa)
	AMD18104.1	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Catalyzes the ferredoxin-dependent oxidative decarboxylation 2-oxoglutarate forming succinyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
	gap	Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the formation of 3-phospho-D-glycerol phosphate from D-glyceraldehyde 3-phosphate in glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
	cofD	LPPG:FO 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (301 aa)
	AMD18164.1	Coenzyme F420:L-glutamate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
	AMD18229.1	Phosphopantothenoylcysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
	AMD18230.1	Phosphopantothenoylcysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
	AMD18268.1	Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
	AMD18270.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
	AMD18315.1	Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
	aroE	Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (283 aa)

Your Current Organism:

Methanobrevibacter sp. YE315

NCBI taxonomy Id: 1609968
Other names: M. sp. YE315

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMD16918.1	AMD17812.1	TL18_02085	TL18_07140	Phosphoenolpyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family.	0.587
AMD16922.1	AMD16924.1	TL18_02105	TL18_02120	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AMD16922.1	AMD17068.1	TL18_02105	TL18_02930	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Indolepyruvate oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.928
AMD16922.1	AMD17147.1	TL18_02105	TL18_03400	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
AMD16922.1	AMD17743.1	TL18_02105	TL18_06755	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.916
AMD16922.1	AMD17812.1	TL18_02105	TL18_07140	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family.	0.962
AMD16922.1	AMD17912.1	TL18_02105	TL18_07665	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.831
AMD16922.1	AMD18104.1	TL18_02105	TL18_08815	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Catalyzes the ferredoxin-dependent oxidative decarboxylation 2-oxoglutarate forming succinyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.928
AMD16922.1	AMD18423.1	TL18_02105	TL18_02115	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AMD16922.1	porA	TL18_02105	TL18_02110	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AMD16924.1	AMD16922.1	TL18_02120	TL18_02105	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AMD16924.1	AMD17147.1	TL18_02120	TL18_03400	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.924
AMD16924.1	AMD17743.1	TL18_02120	TL18_06755	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.906
AMD16924.1	AMD17812.1	TL18_02120	TL18_07140	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family.	0.954
AMD16924.1	AMD17912.1	TL18_02120	TL18_07665	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.819
AMD16924.1	AMD18423.1	TL18_02120	TL18_02115	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998
AMD16924.1	porA	TL18_02120	TL18_02110	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AMD17003.1	AMD17071.1	TL18_02565	TL18_02950	Lactaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	phenylacetate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.873
AMD17003.1	AMD17147.1	TL18_02565	TL18_03400	Lactaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.767
AMD17003.1	AMD17264.1	TL18_02565	TL18_04035	Lactaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	(4Fe-4S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.480