(16 nodes) Ribonucleoside bisphosphate biosynthetic process network (Methanobrevibacter sp. YE315)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	AMD16922.1	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
	porA	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
	AMD18423.1	Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (80 aa)
	AMD16924.1	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
	AMD17068.1	Indolepyruvate oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
	AMD17147.1	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (554 aa)
	AMD17476.1	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (314 aa)
	AMD17495.1	GHMP kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
	AMD17566.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
	AMD17619.1	Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (169 aa)
	AMD17758.1	Glycerol-3-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
	coaD	Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the eukaryotic CoaD family. (152 aa)
	AMD18104.1	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Catalyzes the ferredoxin-dependent oxidative decarboxylation 2-oxoglutarate forming succinyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
	mfnA	L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (385 aa)
	AMD18229.1	Phosphopantothenoylcysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
	AMD18230.1	Phosphopantothenoylcysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)

Your Current Organism:

Methanobrevibacter sp. YE315

NCBI taxonomy Id: 1609968
Other names: M. sp. YE315

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMD16922.1	AMD16924.1	TL18_02105	TL18_02120	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AMD16922.1	AMD17068.1	TL18_02105	TL18_02930	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Indolepyruvate oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.928
AMD16922.1	AMD17147.1	TL18_02105	TL18_03400	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
AMD16922.1	AMD18104.1	TL18_02105	TL18_08815	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Catalyzes the ferredoxin-dependent oxidative decarboxylation 2-oxoglutarate forming succinyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.928
AMD16922.1	AMD18423.1	TL18_02105	TL18_02115	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AMD16922.1	porA	TL18_02105	TL18_02110	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AMD16924.1	AMD16922.1	TL18_02120	TL18_02105	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AMD16924.1	AMD17147.1	TL18_02120	TL18_03400	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.924
AMD16924.1	AMD18423.1	TL18_02120	TL18_02115	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998
AMD16924.1	porA	TL18_02120	TL18_02110	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AMD17068.1	AMD16922.1	TL18_02930	TL18_02105	Indolepyruvate oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.928
AMD17068.1	porA	TL18_02930	TL18_02110	Indolepyruvate oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.883
AMD17147.1	AMD16922.1	TL18_03400	TL18_02105	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
AMD17147.1	AMD16924.1	TL18_03400	TL18_02120	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.924
AMD17147.1	AMD18423.1	TL18_03400	TL18_02115	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.924
AMD17147.1	porA	TL18_03400	TL18_02110	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.933
AMD17476.1	AMD17495.1	TL18_05250	TL18_05355	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.	GHMP kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.947
AMD17476.1	AMD17566.1	TL18_05250	TL18_05735	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.500
AMD17495.1	AMD17476.1	TL18_05355	TL18_05250	GHMP kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.	0.947
AMD17495.1	AMD17566.1	TL18_05355	TL18_05735	GHMP kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.985