STRINGSTRING
rps4e rps4e rpl24p rpl24p rpl14 rpl14 rps17 rps17 rpl29 rpl29 rps3 rps3 rpl22 rpl22 rps19p rps19p rpl2p rpl2p rpl23 rpl23 rpl4lp rpl4lp rpl3 rpl3 AMD17880.1 AMD17880.1 rps17e rps17e AMD17955.1 AMD17955.1 AMD17998.1 AMD17998.1 AMD18027.1 AMD18027.1 rps10p rps10p rps7 rps7 rps12 rps12 rpl30e rpl30e AMD18148.1 AMD18148.1 top6B top6B top6A top6A rpl10e rpl10e AMD18222.1 AMD18222.1 nop10 nop10 rps27e rps27e rpl44e rpl44e rfc rfc rfcL rfcL rps15 rps15 AMD17191.1 AMD17191.1 AMD17222.1 AMD17222.1 rpl37ae rpl37ae AMD17268.1 AMD17268.1 priL priL priS priS rpl40e rpl40e rpl37e rpl37e rps27ae rps27ae rps24e rps24e AMD17622.1 AMD17622.1 rps6e rps6e rpl24e rpl24e rps28e rps28e rpl7ae rpl7ae AMD17630.1 AMD17630.1 AMD17657.1 AMD17657.1 rps8e rps8e AMD17784.1 AMD17784.1 AMD18466.1 AMD18466.1 rps2 rps2 rps9 rps9 rpl13 rpl13 rpl18e rpl18e rps11 rps11 rps4 rps4 rps13 rps13 AMD17851.1 AMD17851.1 rpl34e rpl34e rpl15 rpl15 rpl30p rpl30p rps5 rps5 AMD17046.1 AMD17046.1 rpl18 rpl18 rpl19e rpl19e AMD17862.1 AMD17862.1 rpl6 rpl6 rps8 rps8 rpl5 rpl5 dnaG dnaG AMD16927.1 AMD16927.1 rpl12p rpl12p rplP0 rplP0 rpl1 rpl1 rpl11 rpl11 spt5 spt5 rps3ae rps3ae AMD16790.1 AMD16790.1 albA albA rpl18a rpl18a rpl31e rpl31e rpl39e rpl39e topA topA rpl21e rpl21e AMD16579.1 AMD16579.1 AMD16577.1 AMD16577.1 AMD17036.1 AMD17036.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rps4e30S ribosomal protein S4e; The function of this ribosomal subunit is unknown; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
rpl24p50S ribosomal protein L24; Located at the polypeptide exit tunnel on the outside of the subunit. (116 aa)
rpl1450S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (132 aa)
rps1730S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (105 aa)
rpl2950S ribosomal protein L29; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uL29 family. (68 aa)
rps330S ribosomal protein S3; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (252 aa)
rpl2250S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (154 aa)
rps19p30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (136 aa)
rpl2p50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (241 aa)
rpl2350S ribosomal protein L23; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa)
rpl4lp50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (254 aa)
rpl350S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (336 aa)
AMD17880.1RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
rps17e30S ribosomal protein S17e; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS17 family. (65 aa)
AMD17955.1Histone; Derived by automated computational analysis using gene prediction method: Protein Homology. (66 aa)
AMD17998.1GTP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (340 aa)
AMD18027.1Restriction endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
rps10p30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rps730S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (186 aa)
rps1230S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (141 aa)
rpl30e50S ribosomal protein L30; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eL30 family. (98 aa)
AMD18148.1Similar to yeast Dim2p protein that is essential for 40S ribosomal subunit; structural studies show binding to 3' end of 16S rRNA in complex with archaeal IF2 alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
top6BDNA topoisomerase VI subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (567 aa)
top6ADNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (364 aa)
rpl10e50S ribosomal protein L10e; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uL16 family. (162 aa)
AMD18222.1DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (595 aa)
nop10Ribosome biogenesis protein Nop10; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (55 aa)
rps27e30S ribosomal protein S27; Derived by automated computational analysis using gene prediction method: Protein Homology. (59 aa)
rpl44e50S ribosomal protein L44; Binds to the 23S rRNA. (92 aa)
rfcReplication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (315 aa)
rfcLATPase AAA; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (506 aa)
rps1530S ribosomal protein S15; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
AMD17191.150S ribosomal protein L15e; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
AMD17222.1ADP-ribosylglycohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
rpl37ae50S ribosomal protein L37; Binds to the 23S rRNA. (89 aa)
AMD17268.1Ribonucleotide-diphosphate reductase subunit beta; Probably involved in the biogenesis of the ribosome. (161 aa)
priLDNA primase; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (442 aa)
priSDNA primase; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play [...] (325 aa)
rpl40e50S ribosomal protein L40; Contains a zinc-finger motif; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eL40 family. (48 aa)
rpl37e50S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (62 aa)
rps27ae30S ribosomal protein S27; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS31 family. (50 aa)
rps24e30S ribosomal protein S24; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS24 family. (106 aa)
AMD17622.1PilT domain protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
rps6e30S ribosomal protein S6; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS6 family. (127 aa)
rpl24e50S ribosomal protein L24; Binds to the 23S rRNA. (53 aa)
rps28e30S ribosomal protein S28; The function of S28E in the ribosome is unknown but the structure shows a variants OB-fold that is found in nucleic acid-binding proteins; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS28 family. (68 aa)
rpl7ae50S ribosomal protein L7; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (122 aa)
AMD17630.1Histone; Derived by automated computational analysis using gene prediction method: Protein Homology. (66 aa)
AMD17657.1Shwachman#Bodian#Diamond syndrome protein family; SBDS; similar to eukaryotic proteins involved in RNA metabolism or binding; Derived by automated computational analysis using gene prediction method: Protein Homology. (233 aa)
rps8e30S ribosomal protein S8e; Derived by automated computational analysis using gene prediction method: Protein Homology. (124 aa)
AMD17784.1DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)
AMD18466.1Crystallin; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
rps230S ribosomal protein S2; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS2 family. (200 aa)
rps930S ribosomal protein S9; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS9 family. (133 aa)
rpl1350S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (141 aa)
rpl18e50S ribosomal protein L18e; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eL18 family. (121 aa)
rps1130S ribosomal protein S11; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (130 aa)
rps430S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (179 aa)
rps1330S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (149 aa)
AMD17851.150S ribosomal protein L14e; Derived by automated computational analysis using gene prediction method: Protein Homology. (73 aa)
rpl34e50S ribosomal protein L34; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eL34 family. (88 aa)
rpl1550S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (145 aa)
rpl30p50S ribosomal protein L30; L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
rps530S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy. (213 aa)
AMD17046.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0145 family. (107 aa)
rpl1850S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (193 aa)
rpl19e50S ribosomal protein L19; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (151 aa)
AMD17862.150S ribosomal protein L32; Derived by automated computational analysis using gene prediction method: Protein Homology. (109 aa)
rpl650S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa)
rps830S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rpl550S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (170 aa)
dnaGHypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (414 aa)
AMD16927.1ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
rpl12p50S ribosomal protein L12; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (102 aa)
rplP0Acidic ribosomal protein P0; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (336 aa)
rpl150S ribosomal protein L1; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (212 aa)
rpl1150S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (160 aa)
spt5Antitermination protein NusG; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (156 aa)
rps3ae30S ribosomal protein S3Ae; The function for this protein is unknown; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eS1 family. (193 aa)
AMD16790.1ATPase AAA; Involved in regulation of DNA replication. (372 aa)
albADNA/RNA-binding protein albA; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family. (91 aa)
rpl18a50S ribosomal protein LX; Derived by automated computational analysis using gene prediction method: Protein Homology. (74 aa)
rpl31e50S ribosomal protein L31; One of the proteins encircling the polypeptide exit tunnel in the ribozyme; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribosomal protein L31e family. (81 aa)
rpl39e50S ribosomal protein L39; Part of the polypeptide exit tunnel in the 50S ribosomal complex; Derived by automated computational analysis using gene prediction method: Protein Homology. (51 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (718 aa)
rpl21e50S ribosomal protein L21; Mediates an interaction between 5S and domains II and V of 23S; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the eukaryotic ribosomal protein eL21 family. (96 aa)
AMD16579.1Cell division control protein Cdc6; Involved in regulation of DNA replication. (387 aa)
AMD16577.1Histone; Derived by automated computational analysis using gene prediction method: Protein Homology. (67 aa)
AMD17036.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa)
Your Current Organism:
Methanobrevibacter sp. YE315
NCBI taxonomy Id: 1609968
Other names: M. sp. YE315
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