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| | ilvD | Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (549 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (433 aa) |
| | AMD16563.1 | Citramalate synthase; Catalyzes condensation of pyruvate and acetyl-CoA to form (R)-citramalate; functions in isoleucine synthesis; belongs to the alpha-IPM synthetase/homocitrate synthase family; it is difficult distinguishing these proteins from enzymes in that family; Derived by automated computational analysis using gene prediction method: Protein Homology. (511 aa) |
| | AMD16569.1 | Cobyrinic acid a,c-diamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (498 aa) |
| | AMD16571.1 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (227 aa) |
| | ribK | Riboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (124 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (286 aa) |
| | cobD | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (345 aa) |
| | AMD16582.1 | Cobalamin biosynthesis protein CbiG; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa) |
| | AMD16588.1 | cobalt-precorrin-3B C(17)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa) |
| | AMD16594.1 | Sirohydrochlorin cobaltochelatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa) |
| | cbiX | Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (165 aa) |
| | thiL | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (308 aa) |
| | AMD16598.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (138 aa) |
| | AMD16606.1 | Isocitrate dehydrogenase; Catalyzes the formation of 2-oxoglutarate from isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa) |
| | leuD | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (159 aa) |
| | leuC | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (414 aa) |
| | AMD16619.1 | CDP-glycerol:glycerophosphate glycerophosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (423 aa) |
| | AMD16629.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa) |
| | AMD16645.1 | Pyridoxamine 5'-phosphate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa) |
| | AMD16665.1 | Potassium transporter TrkA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the precorrin methyltransferase family. (234 aa) |
| | hpt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (189 aa) |
| | hisF | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (274 aa) |
| | argD | Acetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (386 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (427 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (286 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (432 aa) |
| | AMD16742.1 | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (451 aa) |
| | AMD16751.1 | UbiC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (417 aa) |
| | AMD16756.1 | Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (588 aa) |
| | AMD16787.1 | Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa) |
| | AMD16788.1 | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa) |
| | mptE | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (239 aa) |
| | AMD16795.1 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. (251 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (366 aa) |
| | AMD16811.1 | Membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (210 aa) |
| | thiC-2 | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (424 aa) |
| | AMD16816.1 | Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa) |
| | thiI | tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (384 aa) |
| | fbp | Fructose 1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (365 aa) |
| | AMD16848.1 | Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (246 aa) |
| | AMD16855.1 | Biotin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa) |
| | AMD16913.1 | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (445 aa) |
| | AMD16917.1 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (495 aa) |
| | AMD16918.1 | Phosphoenolpyruvate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (879 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (305 aa) |
| | carA | Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa) |
| | carB | Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1058 aa) |
| | AMD17009.1 | D-3-phosphoglycerate dehydrogenase; Catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (524 aa) |
| | AMD17074.1 | Pyridoxamine 5'-phosphate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa) |
| | argJ | Ornithine acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (404 aa) |
| | AMD17099.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (287 aa) |
| | AMD17104.1 | Isocitrate dehydrogenase; Catalyzes the formation of 2-oxoglutarate from isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa) |
| | AMD17106.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa) |
| | AMD17115.1 | Carboxylate--amine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa) |
| | cimA | Citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (489 aa) |
| | cobQ | Cobalamin biosynthesis protein CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (508 aa) |
| | AMD17251.1 | ATP phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa) |
| | cbiM | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (221 aa) |
| | cbiN | Cobalamin biosynthesis protein CbiN; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (95 aa) |
| | AMD17260.1 | Catalyzes the formation of riboflavin and 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine from 6,7-dimethyl-8-(1-D-ribityl)lumazine; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa) |
| | AMD17272.1 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HisA/HisF family. (229 aa) |
| | AMD17293.1 | seryl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa) |
| | AMD17298.1 | Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa) |
| | AMD17349.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa) |
| | AMD17393.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (795 aa) |
| | AMD17394.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (794 aa) |
| | AMD17437.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa) |
| | AMD17476.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (314 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (376 aa) |
| | aroA | Fructose-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (263 aa) |
| | AMD17500.1 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa) |
| | cofH | FO synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (372 aa) |
| | AMD17511.1 | Sulfopyruvate decarboxylase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa) |
| | AMD17512.1 | Sulfopyruvate decarboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa) |
| | AMD17517.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa) |
| | AMD17518.1 | Phosphosulfolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa) |
| | cpgS | 2,3-diphosphoglycerate synthetase; Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP. (459 aa) |
| | uppS | UDP diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids. (254 aa) |
| | cbiF | Catalyzes the formation of cobalt-precorrin-5 from cobalt-precorrin-4; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa) |
| | AMD17529.1 | Methionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa) |
| | AMD17576.1 | Homoserine dehydrogenase; Catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa) |
| | AMD17580.1 | Asparagine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa) |
| | metXA | MetX; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (488 aa) |
| | AMD17594.1 | Creatinine amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa) |
| | AMD18455.1 | Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa) |
| | AMD17612.1 | O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa) |
| | argH | Argininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa) |
| | AMD17631.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (398 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (224 aa) |
| | cbiT | SAM-dependent methyltransferase; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (187 aa) |
| | AMD17669.1 | O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa) |
| | AMD17672.1 | Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa) |
| | AMD17673.1 | Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (439 aa) |
| | AMD17678.1 | Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa) |
| | AMD17690.1 | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa) |
| | thiI-2 | tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (383 aa) |
| | AMD17738.1 | Pyridoxamine 5'-phosphate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (242 aa) |
| | AMD17759.1 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa) |
| | AMD17771.1 | uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa) |
| | AMD17785.1 | Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (364 aa) |
| | AMD17791.1 | Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa) |
| | dapL | L,L-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (411 aa) |
| | AMD17829.1 | Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa) |
| | AMD17883.1 | Pyruvate carboxylase subunit A; Catalyzes the ATP-dependent carboxylation of a covalently attached biotin and the transfer of the carboxyl group to pyruvate forming oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa) |
| | AMD17917.1 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (309 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | dapA | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | AMD17944.1 | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (406 aa) |
| | aroK | Shikimate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa) |
| | cbiD | cobalt-precorrin-6A synthase; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (358 aa) |
| | hacB | 3-isopropylmalate dehydratase; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD family. LeuD ty [...] (160 aa) |
| | AMD17970.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (340 aa) |
| | AMD18074.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa) |
| | AMD18085.1 | Precorrin-6x reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (288 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (206 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (222 aa) |
| | cobS | Cobalamin biosynthesis protein CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (260 aa) |
| | queC | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (225 aa) |
| | AMD18120.1 | Pyruvate carboxylase subunit B; Catalyzes the formation of oxaloacetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (570 aa) |
| | AMD18121.1 | Inositol-3-phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the formation of 3-phospho-D-glycerol phosphate from D-glyceraldehyde 3-phosphate in glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa) |
| | AMD18187.1 | Cobalamin biosynthesis protein CobY; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa) |
| | AMD18205.1 | 2-phosphosulfolactate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa) |
| | cofG | FO synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (363 aa) |
| | AMD18221.1 | Sulfolactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa) |
| | AMD18233.1 | Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa) |
| | queE | Radical SAM protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (232 aa) |
| | AMD18237.1 | 6-carboxy-5,6,7,8-tetrahydropterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (171 aa) |
| | argG | Argininosuccinate synthase; Catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (392 aa) |
| | AMD18270.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa) |
| | AMD18488.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (829 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa) |
| | trpB-2 | Phosphoribosylanthranilate isomerase; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpF | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (199 aa) |
| | AMD18306.1 | Indole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (335 aa) |
| | AMD18308.1 | Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa) |
| | AMD18309.1 | Anthranilate synthase subunit I; Derived by automated computational analysis using gene prediction method: Protein Homology. (498 aa) |
| | AMD18319.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (454 aa) |
| | hisH | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (198 aa) |
| | AMD18329.1 | cobalt-precorrin-6Y C(5)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (283 aa) |
| | hisS | histidyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family. (431 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (135 aa) |
| | AMD18356.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0284 family. (355 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa) |
| | cbiA | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (451 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa) |
| | AMD18383.1 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (161 aa) |
| | AMD18384.1 | Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (564 aa) |
| | AMD18387.1 | Ornithine carbamoyltransferase; Catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (302 aa) |
| | cbiC | Catalyzes the interconversion of precorrin-8X and cobyrinic acid; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (423 aa) |
