(11 nodes) Nicotinate and nicotinamide metabolism network (Methanobrevibacter sp. YE315)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nadA	Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (305 aa)
	AMD16971.1	Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (274 aa)
	nadX	Aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (254 aa)
	AMD17299.1	NudC; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
	AMD17328.1	Nicotinate phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
	surE	Hypothetical protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (271 aa)
	AMD17554.1	Nicotinamide-nucleotide adenylyltransferase; Catalyzes the formation of NAD+ from nicotinamide ribonucleotide and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
	nadK	Inorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (619 aa)
	cobB	NAD-dependent deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily. (241 aa)
	nadE	NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (262 aa)
	surE-2	Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (258 aa)

Your Current Organism:

Methanobrevibacter sp. YE315

NCBI taxonomy Id: 1609968
Other names: M. sp. YE315

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMD16971.1	AMD17299.1	TL18_02385	TL18_04230	Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	NudC; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.909
AMD16971.1	AMD17554.1	TL18_02385	TL18_05675	Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	Nicotinamide-nucleotide adenylyltransferase; Catalyzes the formation of NAD+ from nicotinamide ribonucleotide and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.941
AMD16971.1	nadA	TL18_02385	TL18_02370	Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.	0.999
AMD16971.1	nadE	TL18_02385	TL18_10145	Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.	0.617
AMD16971.1	nadX	TL18_02385	TL18_02580	Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	Aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.	0.428
AMD16971.1	surE	TL18_02385	TL18_04990	Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	Hypothetical protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.907
AMD16971.1	surE-2	TL18_02385	TL18_10380	Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.907
AMD17299.1	AMD16971.1	TL18_04230	TL18_02385	NudC; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.909
AMD17299.1	AMD17328.1	TL18_04230	TL18_04385	NudC; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nicotinate phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
AMD17299.1	AMD17554.1	TL18_04230	TL18_05675	NudC; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nicotinamide-nucleotide adenylyltransferase; Catalyzes the formation of NAD+ from nicotinamide ribonucleotide and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.902
AMD17299.1	cobB	TL18_04230	TL18_09655	NudC; Derived by automated computational analysis using gene prediction method: Protein Homology.	NAD-dependent deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.	0.909
AMD17299.1	nadE	TL18_04230	TL18_10145	NudC; Derived by automated computational analysis using gene prediction method: Protein Homology.	NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.	0.914
AMD17299.1	nadK	TL18_04230	TL18_08525	NudC; Derived by automated computational analysis using gene prediction method: Protein Homology.	Inorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.906
AMD17299.1	surE	TL18_04230	TL18_04990	NudC; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.927
AMD17299.1	surE-2	TL18_04230	TL18_10380	NudC; Derived by automated computational analysis using gene prediction method: Protein Homology.	Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.926
AMD17328.1	AMD17299.1	TL18_04385	TL18_04230	Nicotinate phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	NudC; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
AMD17328.1	AMD17554.1	TL18_04385	TL18_05675	Nicotinate phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nicotinamide-nucleotide adenylyltransferase; Catalyzes the formation of NAD+ from nicotinamide ribonucleotide and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.939
AMD17328.1	cobB	TL18_04385	TL18_09655	Nicotinate phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	NAD-dependent deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily.	0.900
AMD17328.1	surE	TL18_04385	TL18_04990	Nicotinate phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.900
AMD17328.1	surE-2	TL18_04385	TL18_10380	Nicotinate phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.900