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cobD cobD AMD16582.1 AMD16582.1 AMD16588.1 AMD16588.1 cbiX cbiX AMD16665.1 AMD16665.1 cobQ cobQ AMD17287.1 AMD17287.1 cbiF cbiF cbiT cbiT AMD17700.1 AMD17700.1 AMD17749.1 AMD17749.1 AMD17771.1 AMD17771.1 AMD17789.1 AMD17789.1 gltX gltX AMD17936.1 AMD17936.1 cbiD cbiD AMD18061.1 AMD18061.1 AMD18062.1 AMD18062.1 AMD18085.1 AMD18085.1 cobS cobS hemA hemA AMD18479.1 AMD18479.1 AMD18187.1 AMD18187.1 AMD18490.1 AMD18490.1 AMD18495.1 AMD18495.1 AMD18329.1 AMD18329.1 cbiA cbiA hemL hemL cbiC cbiC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cobDCobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (345 aa)
AMD16582.1Cobalamin biosynthesis protein CbiG; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
AMD16588.1cobalt-precorrin-3B C(17)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
cbiXSirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (165 aa)
AMD16665.1Potassium transporter TrkA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the precorrin methyltransferase family. (234 aa)
cobQCobalamin biosynthesis protein CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (508 aa)
AMD17287.1Nitrogenase iron protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NifH/BchL/ChlL family. (264 aa)
cbiFCatalyzes the formation of cobalt-precorrin-5 from cobalt-precorrin-4; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
cbiTSAM-dependent methyltransferase; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (187 aa)
AMD17700.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
AMD17749.1uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
AMD17771.1uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
AMD17789.1Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (333 aa)
gltXglutamyl-tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (556 aa)
AMD17936.1Adenosylcobinamide amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
cbiDcobalt-precorrin-6A synthase; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (358 aa)
AMD18061.1UDP-N-acetylmuramyl peptide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
AMD18062.1Porphobilinogen deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
AMD18085.1Precorrin-6x reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
cobSCobalamin biosynthesis protein CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (260 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (400 aa)
AMD18479.1Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
AMD18187.1Cobalamin biosynthesis protein CobY; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
AMD18490.1Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. (1610 aa)
AMD18495.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
AMD18329.1cobalt-precorrin-6Y C(5)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
cbiACobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (451 aa)
hemLGlutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
cbiCCatalyzes the interconversion of precorrin-8X and cobyrinic acid; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
Your Current Organism:
Methanobrevibacter sp. YE315
NCBI taxonomy Id: 1609968
Other names: M. sp. YE315
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