STRINGSTRING
HALO4598 HALO4598 HALO0014 HALO0014 gmk gmk recG recG pstB pstB HALO0059 HALO0059 engB engB HALO0160 HALO0160 HALO0200 HALO0200 HALO0203 HALO0203 phnC phnC HALO0243 HALO0243 HALO0270 HALO0270 HALO0281 HALO0281 HALO0282 HALO0282 HALO0285 HALO0285 ureG ureG HALO0348 HALO0348 HALO0372 HALO0372 HALO0373 HALO0373 HALO0409 HALO0409 HALO0411 HALO0411 HALO0421 HALO0421 HALO0461 HALO0461 znuC znuC HALO0532 HALO0532 HALO0561 HALO0561 HALO0572 HALO0572 HALO0610 HALO0610 HALO0648 HALO0648 HALO0656 HALO0656 HALO0712 HALO0712 HALO0719 HALO0719 HALO0723 HALO0723 HALO0752 HALO0752 HALO0795 HALO0795 HALO0810 HALO0810 HALO0814 HALO0814 HALO0815 HALO0815 araG araG HALO0864 HALO0864 HALO0874 HALO0874 HALO0880 HALO0880 HALO0908 HALO0908 HALO0931 HALO0931 HALO0932 HALO0932 HALO0935 HALO0935 clpB clpB radA radA HALO0988 HALO0988 HALO0989 HALO0989 HALO0991 HALO0991 tmcA tmcA hslU hslU priA priA HALO1059 HALO1059 adk adk HALO1132 HALO1132 HALO1151 HALO1151 HALO1158 HALO1158 HALO1160 HALO1160 HALO1229 HALO1229 HALO1311 HALO1311 HALO1313 HALO1313 HALO1323 HALO1323 HALO1324 HALO1324 HALO1336 HALO1336 HALO1348 HALO1348 HALO1363 HALO1363 HALO1379 HALO1379 HALO1385 HALO1385 HALO1394 HALO1394 HALO1400 HALO1400 HALO1424 HALO1424 HALO1523 HALO1523 ychF ychF HALO1553 HALO1553 potA potA HALO1589 HALO1589 HALO1604 HALO1604 HALO1651 HALO1651 HALO1657 HALO1657 HALO1658 HALO1658 recD recD recB recB recC recC HALO1678 HALO1678 HALO1699 HALO1699 HALO1715 HALO1715 HALO1736 HALO1736 HALO1739 HALO1739 HALO1746 HALO1746 HALO1748 HALO1748 HALO1752 HALO1752 HALO1777 HALO1777 HALO1784 HALO1784 HALO1793 HALO1793 potA-2 potA-2 cysA cysA dnaX dnaX HALO1884 HALO1884 pstB-2 pstB-2 HALO1930 HALO1930 HALO1945 HALO1945 HALO1993 HALO1993 malT malT HALO2001 HALO2001 HALO2009 HALO2009 HALO2034 HALO2034 HALO2037 HALO2037 HALO2042 HALO2042 HALO2045 HALO2045 HALO2048 HALO2048 HALO2049 HALO2049 HALO2050 HALO2050 HALO2051 HALO2051 rho rho HALO2066 HALO2066 HALO2093 HALO2093 cobQ cobQ HALO2108 HALO2108 HALO2109 HALO2109 HALO2115 HALO2115 HALO2116 HALO2116 mfd mfd HALO2162 HALO2162 HALO2186 HALO2186 HALO2220 HALO2220 HALO2225 HALO2225 metN metN HALO2240 HALO2240 HALO2258 HALO2258 rhlE rhlE HALO2277 HALO2277 HALO2278 HALO2278 HALO2285 HALO2285 clpX clpX lon lon HALO2322 HALO2322 HALO2330 HALO2330 HALO2354 HALO2354 HALO2382 HALO2382 rbsA rbsA ruvB ruvB uvrB uvrB prfC prfC HALO2587 HALO2587 coaE coaE cmk cmk HALO2660 HALO2660 HALO2671 HALO2671 HALO2672 HALO2672 HALO2679 HALO2679 atpD atpD atpA atpA HALO2731 HALO2731 HALO2732 HALO2732 HALO2825 HALO2825 HALO2826 HALO2826 era era lepA lepA dinG dinG rhlB rhlB HALO2883 HALO2883 HALO2887 HALO2887 tmk tmk lpxK lpxK msbA msbA lolD lolD secA secA zapE zapE HALO2958 HALO2958 HALO2963 HALO2963 HALO2967 HALO2967 HALO2992 HALO2992 purA purA hflX hflX miaA miaA HALO3002 HALO3002 rsgA rsgA HALO3017 HALO3017 HALO3054 HALO3054 cysN cysN HALO3086 HALO3086 HALO3098 HALO3098 HALO3115 HALO3115 HALO3127 HALO3127 HALO3154 HALO3154 HALO3197 HALO3197 HALO3246 HALO3246 HALO3247 HALO3247 lon-2 lon-2 HALO3295 HALO3295 HALO3316 HALO3316 HALO3324 HALO3324 HALO3337 HALO3337 HALO3339 HALO3339 HALO3343 HALO3343 HALO3361 HALO3361 HALO3362 HALO3362 HALO3369 HALO3369 HALO3372 HALO3372 HALO3426 HALO3426 HALO3433 HALO3433 HALO3436 HALO3436 HALO3452 HALO3452 HALO3534 HALO3534 HALO3564 HALO3564 HALO3592 HALO3592 HALO3617 HALO3617 HALO3655 HALO3655 HALO3659 HALO3659 HALO3677 HALO3677 HALO3679 HALO3679 HALO3789 HALO3789 HALO3795 HALO3795 smc smc ccmA ccmA recA recA mutS mutS pyrG pyrG aroK aroK HALO3890 HALO3890 HALO3902 HALO3902 HALO3920 HALO3920 der der bioD bioD HALO3984 HALO3984 HALO3997 HALO3997 HALO4006 HALO4006 HALO4007 HALO4007 HALO4029 HALO4029 rho-2 rho-2 ftsE ftsE ftsY ftsY HALO4104 HALO4104 ffh ffh HALO4129 HALO4129 HALO4151 HALO4151 HALO4177 HALO4177 HALO4190 HALO4190 infB infB ftsH ftsH HALO4219 HALO4219 HALO4224 HALO4224 phnC-2 phnC-2 obg obg HALO4286 HALO4286 HALO4292 HALO4292 ugpC ugpC phnC-3 phnC-3 ntrC ntrC HALO4336 HALO4336 HALO4339 HALO4339 tuf tuf fusA fusA HALO4396 HALO4396 HALO4398 HALO4398 HALO4399 HALO4399 rapA rapA uvrA uvrA HALO4436 HALO4436 HALO4462 HALO4462 recF recF dnaA dnaA mnmE mnmE HALO4552 HALO4552 HALO4555 HALO4555 atpA-2 atpA-2 atpD-2 atpD-2 rep rep HALO4586 HALO4586
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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HALO4598Type I restriction enzyme R protein. (782 aa)
HALO0014Type I restriction enzyme R protein. (1136 aa)
gmkGuanylate kinase-GMP kinase; Essential for recycling GMP and indirectly, cGMP. (210 aa)
recGATP-dependent DNA helicase recG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (692 aa)
pstBPhosphate transport system permease protein 1; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (271 aa)
HALO0059DNA helicase, UvrD/REP type. (732 aa)
engBProbable GTP-binding protein EngB; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (212 aa)
HALO0160Putative uncharacterized protein. (656 aa)
HALO0200Putative bifunctional enzyme and transcriptional regulator. (158 aa)
HALO0203TniB family protein. (274 aa)
phnCPhosphonates import ATP-binding protein PhnC 1; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family. (265 aa)
HALO0243ABC transporter-like protein. (258 aa)
HALO0270Putative uncharacterized protein. (260 aa)
HALO0281ABC transporter ATP-binding protein. (278 aa)
HALO0282High-affinity branched-chain amino acid transport ATP-binding protein BraG. (235 aa)
HALO0285ABC-type transport system ATP-binding protein. (260 aa)
ureGUrease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG. (218 aa)
HALO0348Restriction endonuclease, type I, EcoEI, R subunit/Type III. (814 aa)
HALO0372ABC transporter ATP-binding protein. (238 aa)
HALO0373Branched-chain amino acid ABC transporter ATP-binding protein. (241 aa)
HALO0409AAA-like domain protein. (1060 aa)
HALO0411Putative uncharacterized protein in xynA 3'region-ORF6. (692 aa)
HALO0421Cobalamin synthesis protein/P47K family protein. (347 aa)
HALO0461ATPase, type III secretion system, FliI/YscN. (445 aa)
znuCZinc import ATP-binding protein ZnuC; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (247 aa)
HALO0532ABC transporter, transmembrane domain, type 1. (588 aa)
HALO0561Ferric transporter subunit ATP-binding component of ABC transporter CP4-6 prophage; Belongs to the ABC transporter superfamily. (374 aa)
HALO0572ABC transporter ATP-binding protein. (296 aa)
HALO0610Putative uncharacterized protein; Belongs to the ABC transporter superfamily. (552 aa)
HALO0648Octopine permease ATP-binding protein P. (255 aa)
HALO0656Putative uncharacterized protein. (529 aa)
HALO0712Glutamine transport ATP-binding protein GlnQ. (272 aa)
HALO0719Putative uncharacterized protein. (1639 aa)
HALO0723Putative uncharacterized protein. (265 aa)
HALO0752Putative uncharacterized protein. (342 aa)
HALO0795Ferric transporter subunit ATP-binding component of ABC transporter CP4-6 prophage; Belongs to the ABC transporter superfamily. (363 aa)
HALO0810DNA helicase, ATP-dependent, RecQ type, bacterial. (612 aa)
HALO0814Putative sugar transporter subunit: ATP-binding component of ABC superfamily transporter; Belongs to the ABC transporter superfamily. (376 aa)
HALO0815Putative sigma L-dependent transcriptional regulator yqiR. (472 aa)
araGArabinose import ATP-binding protein AraG; Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family. (497 aa)
HALO0864Ribose import ATP-binding protein RbsA. (503 aa)
HALO0874ABC transporter ATP-binding protein; Belongs to the ABC transporter superfamily. (351 aa)
HALO0880Putative transporter subunit: ATP-binding component of ABC superfamily. (313 aa)
HALO0908Putative amino-acid ABC transporter ATP-binding protein. (251 aa)
HALO0931Protein ClpV1; Belongs to the ClpA/ClpB family. (873 aa)
HALO0932Putative uncharacterized protein. (532 aa)
HALO0935Putative uncharacterized protein. (1216 aa)
clpBChaperonin ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (865 aa)
radARepair protein radA homolog; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (458 aa)
HALO0988ATP-binding/permease protein CydD. (571 aa)
HALO0989ATP-binding/permease protein CydC. (579 aa)
HALO0991Fe(3+) ions import ATP-binding protein FbpC; Belongs to the ABC transporter superfamily. (367 aa)
tmcAtRNA(Met) cytidine acetyltransferase TmcA; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (709 aa)
hslUATP-dependent protease ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (440 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (740 aa)
HALO1059Putative nucleic acid ATP-dependent helicase. (596 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
HALO1132Putative molybdenum transport ATP-binding protein ModF. (495 aa)
HALO1151Putative transporter subunit: ATP-binding component of ABC superfamily transporter. (242 aa)
HALO1158Sulfate/thiosulfate import ATP-binding protein CysA; Belongs to the ABC transporter superfamily. (382 aa)
HALO1160Cobyrinic acid a,c-diamide synthase. (244 aa)
HALO1229Putative uncharacterized protein. (648 aa)
HALO1311Glycine betaine/L-proline transport ATP-binding subunit. (400 aa)
HALO1313RNA polymerase sigma factor 54, interaction. (466 aa)
HALO1323Putative siderophore transport system ATP-binding protein yusV. (271 aa)
HALO1324Putative uncharacterized protein. (607 aa)
HALO1336Glutamine transport ATP-binding protein GlnQ. (240 aa)
HALO1348Iron-dicitrate transporter subunit ATP-binding component of ABC superfamily KpLE2 phage-like element. (278 aa)
HALO1363Nuclease sbcCD subunit C. (1021 aa)
HALO1379PhoH-like protein. (469 aa)
HALO1385ATP-independent RNA helicase dbpA; Belongs to the DEAD box helicase family. (465 aa)
HALO1394Ribose import ATP-binding protein RbsA. (515 aa)
HALO1400Putative uncharacterized protein. (632 aa)
HALO1424Putative uncharacterized protein. (395 aa)
HALO1523PhoH-like protein. (359 aa)
ychFGTP-dependent nucleic acid-binding protein engD; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (363 aa)
HALO1553Putative uncharacterized protein. (180 aa)
potAABC transporter ATP-binding protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (369 aa)
HALO1589Putative uncharacterized protein. (539 aa)
HALO1604Putative uncharacterized protein. (424 aa)
HALO1651Exodeoxyribonuclease V alpha chain. (130 aa)
HALO1657Putative uncharacterized protein. (662 aa)
HALO1658Putative DNA helicase, DNA helicase UvrD/REP type domain. (593 aa)
recDExodeoxyribonuclease V, subunit alpha; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] (765 aa)
recBExodeoxyribonuclease V beta chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repai [...] (1251 aa)
recCExodeoxyribonuclease V, subunit gamma; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] (1205 aa)
HALO1678Putative transporter subunit: ATP-binding component of ABC superfamily transporter. (256 aa)
HALO1699Putative uncharacterized protein. (640 aa)
HALO1715Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (462 aa)
HALO1736Phosphoribulokinase. (290 aa)
HALO1739ABC transporter, ATP-binding protein, ChvD. (562 aa)
HALO1746AAA ATPase. (733 aa)
HALO1748Putative uncharacterized protein. (843 aa)
HALO1752Type I site-specific deoxyribonuclease. (816 aa)
HALO1777DNA/RNA helicase, superfamily II. (459 aa)
HALO1784ATPase, type I secretion system. (725 aa)
HALO1793Putative uncharacterized protein. (266 aa)
potA-2Spermidine/putrescine import ATP-binding protein PotA; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (393 aa)
cysAABC transporter ATP-binding protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (364 aa)
dnaXDNA polymerase III, subunit gamma/ tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (667 aa)
HALO1884ATP-dependent RNA helicase HrpA. (1303 aa)
pstB-2Phosphate transport system permease protein 1; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (279 aa)
HALO1930ABC transporter ATP-binding protein uup-1. (638 aa)
HALO1945Putative ATP-dependent transporter SufC. (249 aa)
HALO1993Maltose/maltodextrin import ATP-binding protein MalK; Belongs to the ABC transporter superfamily. (368 aa)
malTTranscriptional regulator MalT; Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto- oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box. (901 aa)
HALO2001Maltose/maltodextrin transporter ATP-binding protein; Belongs to the ABC transporter superfamily. (373 aa)
HALO2009Osmosensitive K channel His kinase sensor. (894 aa)
HALO2034Cobinamide kinase/cobinamide phosphate guanyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (183 aa)
HALO2037Putative uncharacterized protein. (141 aa)
HALO2042ABC transporter related protein. (256 aa)
HALO2045Fe(3+) dicitrate transport ATP-binding protein FecE. (254 aa)
HALO2048Putative uncharacterized protein. (583 aa)
HALO2049Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (197 aa)
HALO2050Cobyrinic acid A,C-diamide synthase. (456 aa)
HALO2051Protein CobW. (377 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (318 aa)
HALO2066ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. (395 aa)
HALO2093Ferric transporter subunit ATP-binding component of ABC transporter CP4-6 prophage; Belongs to the ABC transporter superfamily. (360 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (489 aa)
HALO2108ATPase, AAA-5. (284 aa)
HALO2109Acetoin catabolism regulatory protein. (660 aa)
HALO2115Putative oligopeptide transport ATP-binding protein ykfD; Belongs to the ABC transporter superfamily. (353 aa)
HALO2116Oligopeptide transport ATP-binding protein oppD; Belongs to the ABC transporter superfamily. (338 aa)
mfdTranscription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1149 aa)
HALO2162DNA polymerase III, delta subunit. (355 aa)
HALO2186Adenylate kinase-like kinase. (157 aa)
HALO2220ATPase-like, ParA/MinD; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (266 aa)
HALO2225Chromosomal replication control, regulator Hda; Belongs to the DnaA family. HdA subfamily. (235 aa)
metNMethionine import ATP-binding protein MetN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (347 aa)
HALO2240Molybdopterin-guanine dinucleotide biosynthesis protein B. (192 aa)
HALO2258Putative uncharacterized protein. (1299 aa)
rhlEATP-dependent RNA helicase rhlE; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. (418 aa)
HALO2277ATP-binding/permease protein CydD. (557 aa)
HALO2278ABC transporter, CydDC cysteine exporter (CydDC-E) family, p. (568 aa)
HALO2285ATP-dependent RNA helicase hrpB. (810 aa)
clpXATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (426 aa)
lonLon protease-ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (803 aa)
HALO2322Putative transporter subunit: ATP-binding component of ABC superfamily transporter. (320 aa)
HALO2330ABC transporter ATP-binding protein. (275 aa)
HALO2354Putative fused oligopeptide transporter subunits of ABC superfamily: ATP-binding components; Belongs to the ABC transporter superfamily. (527 aa)
HALO2382Putative uncharacterized protein. (932 aa)
rbsASugar ABC transporter ATP-binding protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. (526 aa)
ruvBHolliday junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (345 aa)
uvrBUvrABC system protein B-Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the U [...] (675 aa)
prfCPeptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (529 aa)
HALO2587Type 4 fimbrial assembly protein pilB. (583 aa)
coaEDephospho-CoA kinase-Dephosphocoenzyme A kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa)
cmkCytidylate kinase-Cytidine monophosphate kinase. (232 aa)
HALO2660Putative uncharacterized protein. (252 aa)
HALO2671ABC transporter, transmembrane domain, type 1. (604 aa)
HALO2672Exopolysaccharide tyrosine-protein kinase. (750 aa)
HALO2679ATPase AAA. (341 aa)
atpDATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (489 aa)
atpAATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (532 aa)
HALO2731Sn-glycerol-3-phosphate import ATP-binding protein UgpC 1; Belongs to the ABC transporter superfamily. (365 aa)
HALO2732Sn-glycerol-3-phosphate import ATP-binding protein UgpC; Belongs to the ABC transporter superfamily. (366 aa)
HALO2825Branched-chain amino acid ABC transporter ATP-binding protein. (247 aa)
HALO2826High-affinity branched-chain amino acid transport ATP-binding protein BraF. (268 aa)
eraGTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (299 aa)
lepAElongation factor 4; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (605 aa)
dinGATP-dependent DNA helicase DinG; DNA-dependent ATPase and 5'-3' DNA helicase. (709 aa)
rhlBATP-dependent RNA helicase RhlB; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (424 aa)
HALO2883ATP-dependent DNA helicase rep. (710 aa)
HALO2887DNA polymerase III subunit delta. (328 aa)
tmkThymidylate kinase-dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (217 aa)
lpxKTetraacyldisaccharide 4'-kinase-Lipid A 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (332 aa)
msbALipid A export ATP-binding/permease protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (578 aa)
lolDLipoprotein-releasing system ATP-binding protein LolD; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. (226 aa)
secAProtein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (910 aa)
zapEPutative uncharacterized protein; Reduces the stability of FtsZ polymers in the presence of ATP. (398 aa)
HALO2958Toluene transporter subunit: ATP-binding component of ABC superfamily. (271 aa)
HALO2963Lipopolysaccharide export system ATP-binding protein LptB. (249 aa)
HALO2967UPF0042 nucleotide-binding protein KUC_3753; Displays ATPase and GTPase activities. (310 aa)
HALO2992Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (199 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa)
hflXGTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (436 aa)
miaAtRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (312 aa)
HALO3002UPF0079 ATP-binding protein yjeE. (171 aa)
rsgAPutative ribosome biogenesis GTPase RsgA; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (339 aa)
HALO3017Bicarbonate transport ATP-binding protein CmpD. (264 aa)
HALO3054Phosphate import ATP-binding protein pstB 1. (243 aa)
cysNSulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (480 aa)
HALO3086Putative transmembrane attachment-related protein. (222 aa)
HALO3098Spermidine/putrescine import ATP-binding protein PotA; Belongs to the ABC transporter superfamily. (336 aa)
HALO3115Glutamine transport ATP-binding protein GlnQ. (294 aa)
HALO3127HPr kinase. (369 aa)
HALO3154Putative uncharacterized protein. (570 aa)
HALO3197ABC transporter ATP-binding protein. (289 aa)
HALO3246Putative branched-chain amino acid transport ATP-binding protein LivG. (250 aa)
HALO3247High-affinity branched-chain amino acid transport ATP-binding protein BraG. (226 aa)
lon-2Lon protease-ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (821 aa)
HALO3295ATPase, type I secretion system, PrtD. (584 aa)
HALO3316Putative uncharacterized protein. (327 aa)
HALO3324Ribosome biogenesis GTPase A; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (318 aa)
HALO3337Replication-associated recombination protein A. (444 aa)
HALO3339Cell division FtsK/SpoIIIE. (1061 aa)
HALO3343ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. (758 aa)
HALO3361Oligopeptide transport ATP-binding protein oppD. (281 aa)
HALO3362Nickel import ATP-binding protein NikE. (212 aa)
HALO3369Putative uncharacterized protein. (467 aa)
HALO3372Putative sugar transporter subunit: ATP-binding component of ABC superfamily transporter; Belongs to the ABC transporter superfamily. (373 aa)
HALO3426Hydrogenase-4 transcriptional activator. (643 aa)
HALO3433Putative uncharacterized protein. (208 aa)
HALO3436Putative sugar transporter subunit: ATP-binding component of ABC superfamily transporter; Belongs to the ABC transporter superfamily. (383 aa)
HALO3452Gluconate kinase 2. (175 aa)
HALO3534Putative uncharacterized protein. (177 aa)
HALO3564Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (727 aa)
HALO3592DEAD-like helicase; Belongs to the DEAD box helicase family. (571 aa)
HALO3617ABC transporter, transmembrane domain, type 1. (579 aa)
HALO3655Multidrug/microcin transport system ATP-binding/permease protein; Fused multidrug transport subunits of ABC superfamily transporter: permease component/ATP-binding component. (552 aa)
HALO3659Cyclic peptide transporter. (574 aa)
HALO3677ABC transporter ATP-binding protein. (255 aa)
HALO3679Cyclic peptide transporter. (550 aa)
HALO3789Uncharacterized conserved protein. (907 aa)
HALO3795Putative uncharacterized protein. (1315 aa)
smcChromosome partition protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1164 aa)
ccmAABC transporter, heme export, CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (206 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (357 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (853 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (551 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (192 aa)
HALO3890Putative uncharacterized protein. (569 aa)
HALO3902ABC transporter ATP-binding protein; Belongs to the ABC transporter superfamily. (546 aa)
HALO3920ABC transporter related protein; Belongs to the ABC transporter superfamily. (555 aa)
derGTPase Der-GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (467 aa)
bioDATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (229 aa)
HALO3984COBW domain-containing protein DDB_G0274527. (408 aa)
HALO3997ATP-dependent DNA helicase recQ. (672 aa)
HALO4006Antimicrobial peptide transporter subunit ATP-binding component of ABC superfamily transporter; Belongs to the ABC transporter superfamily. (349 aa)
HALO4007Dipeptide transport ATP-binding protein DppF; Belongs to the ABC transporter superfamily. (337 aa)
HALO4029Putative sulfate/thiosulfate transporter subunit: ATP-binding component of ABC superfamily transporter. (212 aa)
rho-2Transcription termination factor Rho-ATP-dependent helicase Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa)
ftsEABC transporter ATP-binding protein; Part of the ABC transporter FtsEX involved in cellular division. (222 aa)
ftsYSignal recognition particle receptor FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (436 aa)
HALO4104ABC transporter ATP-binding protein; Belongs to the ABC transporter superfamily. (537 aa)
ffhSignal recognition particle protein-Fifty-four homolog; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the [...] (475 aa)
HALO4129Septum site-determining protein MinD. (272 aa)
HALO4151RNA polymerase sigma factor 54, interaction. (460 aa)
HALO4177Twitching mobility protein. (347 aa)
HALO4190Transcriptional regulatory protein zraR. (485 aa)
infBTranslation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (864 aa)
ftsHATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (676 aa)
HALO4219ABC transporter-like protein. (249 aa)
HALO4224DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (557 aa)
phnC-2ABC transporter, phosphonate import, PhnC; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family. (286 aa)
obgGTPase obg-GTP-binding protein obg; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (395 aa)
HALO4286Helicase, ATP-dependent, c2 type. (764 aa)
HALO4292Putative peptide transport fused subunits of ABC superfamily: ATP-binding components; Belongs to the ABC transporter superfamily. (618 aa)
ugpCPutative sugar transporter subunit: ATP-binding component of ABC superfamily transporter; Part of the ABC transporter complex UgpABCE involved in sn- glycerol-3-phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. sn-glycerol-3- phosphate importer (TC 3.A.1.1.3) family. (351 aa)
phnC-3Phosphate-import ATP-binding protein PhnC; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family. (267 aa)
ntrCNitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (475 aa)
HALO4336CRISPR-associated helicase Cas3 family protein. (892 aa)
HALO4339Putative metal transport system ATP-binding protein. (245 aa)
tufElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (397 aa)
fusAElongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (707 aa)
HALO4396GTP-binding protein TypA/BipA. (616 aa)
HALO4398ABC transporter ATP-binding protein. (256 aa)
HALO4399ABC transporter ATP-binding protein. (202 aa)
rapARNA polymerase-associated protein RapA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. (981 aa)
uvrAUvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (948 aa)
HALO4436Flagellar biosynthesis protein flhF. (727 aa)
HALO4462Flagellum-specific ATP synthase. (464 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (367 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (488 aa)
mnmEtRNA modification GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (456 aa)
HALO4552ABC transporter-like protein. (252 aa)
HALO4555Cobyrinic acid a,c-diamide synthase. (255 aa)
atpA-2ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (514 aa)
atpD-2ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (459 aa)
repDNA helicase, ATP-dependent, RepA type; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (689 aa)
HALO4586Ribose import ATP-binding protein RbsA 2. (495 aa)
Your Current Organism:
Halomonas sp. R575
NCBI taxonomy Id: 1610576
Other names: H. sp. R57-5, Halomonas sp. R57-5
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