(11 nodes) NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis, and Peroxisome proliferator-activated receptor network (Amphiprion percula)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSAPEP00000000133	Nuclear receptor subfamily 1, group H, member 3. (461 aa)
	PPARG	Peroxisome proliferator activated receptor gamma. (567 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (469 aa)
	ENSAPEP00000010016	Nuclear receptor subfamily 1, group H, member 4. (485 aa)
	ENSAPEP00000016222	Nuclear receptor coactivator 1. (1290 aa)
	ENSAPEP00000018471	Retinoid x receptor, beta b. (444 aa)
	ENSAPEP00000020909	Peroxisome proliferator-activated receptor alpha a. (482 aa)
	ENSAPEP00000021495	Retinoid X receptor, alpha a. (496 aa)
	ENSAPEP00000027349	Uncharacterized protein. (341 aa)
	ENSAPEP00000033843	Nuclear receptor coactivator 3. (1554 aa)
	ENSAPEP00000034081	Uncharacterized protein. (465 aa)

Your Current Organism:

Amphiprion percula

NCBI taxonomy Id: 161767
Other names: A. percula, Picasso clownfish, orange clownfish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPEP00000000133	ENSAPEP00000016222	ENSAPEP00000000133	ENSAPEP00000016222	Nuclear receptor subfamily 1, group H, member 3.	Nuclear receptor coactivator 1.	0.942
ENSAPEP00000000133	ENSAPEP00000018471	ENSAPEP00000000133	ENSAPEP00000018471	Nuclear receptor subfamily 1, group H, member 3.	Retinoid x receptor, beta b.	0.971
ENSAPEP00000000133	ENSAPEP00000020909	ENSAPEP00000000133	ENSAPEP00000020909	Nuclear receptor subfamily 1, group H, member 3.	Peroxisome proliferator-activated receptor alpha a.	0.430
ENSAPEP00000000133	ENSAPEP00000021495	ENSAPEP00000000133	ENSAPEP00000021495	Nuclear receptor subfamily 1, group H, member 3.	Retinoid X receptor, alpha a.	0.971
ENSAPEP00000000133	ENSAPEP00000027349	ENSAPEP00000000133	ENSAPEP00000027349	Nuclear receptor subfamily 1, group H, member 3.	Uncharacterized protein.	0.971
ENSAPEP00000000133	ENSAPEP00000033843	ENSAPEP00000000133	ENSAPEP00000033843	Nuclear receptor subfamily 1, group H, member 3.	Nuclear receptor coactivator 3.	0.942
ENSAPEP00000000133	ENSAPEP00000034081	ENSAPEP00000000133	ENSAPEP00000034081	Nuclear receptor subfamily 1, group H, member 3.	Uncharacterized protein.	0.971
ENSAPEP00000000133	PPARA	ENSAPEP00000000133	ENSAPEP00000009647	Nuclear receptor subfamily 1, group H, member 3.	Peroxisome proliferator-activated receptor alpha b.	0.634
ENSAPEP00000000133	PPARG	ENSAPEP00000000133	ENSAPEP00000006947	Nuclear receptor subfamily 1, group H, member 3.	Peroxisome proliferator activated receptor gamma.	0.756
ENSAPEP00000010016	ENSAPEP00000016222	ENSAPEP00000010016	ENSAPEP00000016222	Nuclear receptor subfamily 1, group H, member 4.	Nuclear receptor coactivator 1.	0.895
ENSAPEP00000010016	ENSAPEP00000018471	ENSAPEP00000010016	ENSAPEP00000018471	Nuclear receptor subfamily 1, group H, member 4.	Retinoid x receptor, beta b.	0.910
ENSAPEP00000010016	ENSAPEP00000020909	ENSAPEP00000010016	ENSAPEP00000020909	Nuclear receptor subfamily 1, group H, member 4.	Peroxisome proliferator-activated receptor alpha a.	0.430
ENSAPEP00000010016	ENSAPEP00000021495	ENSAPEP00000010016	ENSAPEP00000021495	Nuclear receptor subfamily 1, group H, member 4.	Retinoid X receptor, alpha a.	0.910
ENSAPEP00000010016	ENSAPEP00000027349	ENSAPEP00000010016	ENSAPEP00000027349	Nuclear receptor subfamily 1, group H, member 4.	Uncharacterized protein.	0.910
ENSAPEP00000010016	ENSAPEP00000033843	ENSAPEP00000010016	ENSAPEP00000033843	Nuclear receptor subfamily 1, group H, member 4.	Nuclear receptor coactivator 3.	0.895
ENSAPEP00000010016	ENSAPEP00000034081	ENSAPEP00000010016	ENSAPEP00000034081	Nuclear receptor subfamily 1, group H, member 4.	Uncharacterized protein.	0.910
ENSAPEP00000010016	PPARA	ENSAPEP00000010016	ENSAPEP00000009647	Nuclear receptor subfamily 1, group H, member 4.	Peroxisome proliferator-activated receptor alpha b.	0.471
ENSAPEP00000010016	PPARG	ENSAPEP00000010016	ENSAPEP00000006947	Nuclear receptor subfamily 1, group H, member 4.	Peroxisome proliferator activated receptor gamma.	0.567
ENSAPEP00000016222	ENSAPEP00000000133	ENSAPEP00000016222	ENSAPEP00000000133	Nuclear receptor coactivator 1.	Nuclear receptor subfamily 1, group H, member 3.	0.942
ENSAPEP00000016222	ENSAPEP00000010016	ENSAPEP00000016222	ENSAPEP00000010016	Nuclear receptor coactivator 1.	Nuclear receptor subfamily 1, group H, member 4.	0.895