(11 nodes) Mixed, incl. Thyroid hormone receptor, and NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis network (Amphiprion percula)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSAPEP00000005285	Nuclear receptor subfamily 1, group D, member 4a. (576 aa)
	ENSAPEP00000006795	Vitamin D receptor b. (425 aa)
	ENSAPEP00000007781	Uncharacterized protein. (409 aa)
	ENSAPEP00000009954	Thyroid hormone receptor beta. (509 aa)
	ENSAPEP00000011219	Nuclear receptor subfamily 1, group d, member 1. (613 aa)
	ENSAPEP00000012264	Nuclear receptor subfamily 1, group H, member 5. (488 aa)
	NCOA3	Nuclear receptor coactivator 3. (1527 aa)
	RXRB	Retinoid X receptor beta. (470 aa)
	ENSAPEP00000022356	Nuclear receptor corepressor 1. (2416 aa)
	THRA	Thyroid hormone receptor alpha. (416 aa)
	ENSAPEP00000033368	Nuclear receptor subfamily 1, group D, member 2a. (600 aa)

Your Current Organism:

Amphiprion percula

NCBI taxonomy Id: 161767
Other names: A. percula, Picasso clownfish, orange clownfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPEP00000005285	ENSAPEP00000006795	ENSAPEP00000005285	ENSAPEP00000006795	Nuclear receptor subfamily 1, group D, member 4a.	Vitamin D receptor b.	0.845
ENSAPEP00000005285	ENSAPEP00000007781	ENSAPEP00000005285	ENSAPEP00000007781	Nuclear receptor subfamily 1, group D, member 4a.	Uncharacterized protein.	0.832
ENSAPEP00000005285	ENSAPEP00000009954	ENSAPEP00000005285	ENSAPEP00000009954	Nuclear receptor subfamily 1, group D, member 4a.	Thyroid hormone receptor beta.	0.832
ENSAPEP00000005285	ENSAPEP00000011219	ENSAPEP00000005285	ENSAPEP00000011219	Nuclear receptor subfamily 1, group D, member 4a.	Nuclear receptor subfamily 1, group d, member 1.	0.548
ENSAPEP00000005285	ENSAPEP00000012264	ENSAPEP00000005285	ENSAPEP00000012264	Nuclear receptor subfamily 1, group D, member 4a.	Nuclear receptor subfamily 1, group H, member 5.	0.888
ENSAPEP00000005285	ENSAPEP00000022356	ENSAPEP00000005285	ENSAPEP00000022356	Nuclear receptor subfamily 1, group D, member 4a.	Nuclear receptor corepressor 1.	0.905
ENSAPEP00000005285	NCOA3	ENSAPEP00000005285	ENSAPEP00000018520	Nuclear receptor subfamily 1, group D, member 4a.	Nuclear receptor coactivator 3.	0.828
ENSAPEP00000005285	RXRB	ENSAPEP00000005285	ENSAPEP00000019644	Nuclear receptor subfamily 1, group D, member 4a.	Retinoid X receptor beta.	0.524
ENSAPEP00000005285	THRA	ENSAPEP00000005285	ENSAPEP00000027442	Nuclear receptor subfamily 1, group D, member 4a.	Thyroid hormone receptor alpha.	0.832
ENSAPEP00000006795	ENSAPEP00000005285	ENSAPEP00000006795	ENSAPEP00000005285	Vitamin D receptor b.	Nuclear receptor subfamily 1, group D, member 4a.	0.845
ENSAPEP00000006795	ENSAPEP00000007781	ENSAPEP00000006795	ENSAPEP00000007781	Vitamin D receptor b.	Uncharacterized protein.	0.497
ENSAPEP00000006795	ENSAPEP00000009954	ENSAPEP00000006795	ENSAPEP00000009954	Vitamin D receptor b.	Thyroid hormone receptor beta.	0.497
ENSAPEP00000006795	ENSAPEP00000022356	ENSAPEP00000006795	ENSAPEP00000022356	Vitamin D receptor b.	Nuclear receptor corepressor 1.	0.886
ENSAPEP00000006795	ENSAPEP00000033368	ENSAPEP00000006795	ENSAPEP00000033368	Vitamin D receptor b.	Nuclear receptor subfamily 1, group D, member 2a.	0.845
ENSAPEP00000006795	NCOA3	ENSAPEP00000006795	ENSAPEP00000018520	Vitamin D receptor b.	Nuclear receptor coactivator 3.	0.885
ENSAPEP00000006795	RXRB	ENSAPEP00000006795	ENSAPEP00000019644	Vitamin D receptor b.	Retinoid X receptor beta.	0.845
ENSAPEP00000006795	THRA	ENSAPEP00000006795	ENSAPEP00000027442	Vitamin D receptor b.	Thyroid hormone receptor alpha.	0.497
ENSAPEP00000007781	ENSAPEP00000005285	ENSAPEP00000007781	ENSAPEP00000005285	Uncharacterized protein.	Nuclear receptor subfamily 1, group D, member 4a.	0.832
ENSAPEP00000007781	ENSAPEP00000006795	ENSAPEP00000007781	ENSAPEP00000006795	Uncharacterized protein.	Vitamin D receptor b.	0.497
ENSAPEP00000007781	ENSAPEP00000009954	ENSAPEP00000007781	ENSAPEP00000009954	Uncharacterized protein.	Thyroid hormone receptor beta.	0.865