(38 nodes) Mixed, incl. TNFR1-induced NFkappaB signaling pathway, and Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon network (Amphiprion percula)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSAPEP00000000714	Pleckstrin homology domain containing, family G (with RhoGef domain) member 5b. (789 aa)
	ENSAPEP00000001423	Si:dkey-181m9.8. (752 aa)
	ENSAPEP00000002471	Mitogen-activated protein kinase kinase kinase 7. (603 aa)
	ENSAPEP00000003497	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (595 aa)
	ENSAPEP00000004292	TNF receptor-associated factor. (477 aa)
	ENSAPEP00000005068	Tumor necrosis factor, alpha-induced protein 3. (825 aa)
	ENSAPEP00000005218	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (620 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (762 aa)
	ENSAPEP00000005629	SHANK-associated RH domain interacting protein. (437 aa)
	ENSAPEP00000005826	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (758 aa)
	ENSAPEP00000006542	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (685 aa)
	ENSAPEP00000009615	Protein kinase domain-containing protein. (107 aa)
	ENSAPEP00000009947	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa)
	ENSAPEP00000010222	BCL3 transcription coactivator. (494 aa)
	ENSAPEP00000011639	Uncharacterized protein. (960 aa)
	ENSAPEP00000012137	TGF-beta activated kinase 1/MAP3K7 binding protein 1. (595 aa)
	ENSAPEP00000012208	Baculoviral IAP repeat containing 7. (398 aa)
	ENSAPEP00000014341	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (956 aa)
	ENSAPEP00000014398	TNF receptor-associated factor. (470 aa)
	ENSAPEP00000016413	Tumor necrosis factor receptor superfamily, member 1a. (393 aa)
	ENSAPEP00000017590	TNFAIP3 interacting protein 1. (659 aa)
	ENSAPEP00000017904	OTU deubiquitinase with linear linkage specificity a. (731 aa)
	ENSAPEP00000018676	Tnfrsf1a-associated via death domain. (292 aa)
	ENSAPEP00000023062	Receptor-interacting serine-threonine kinase 4. (812 aa)
	ENSAPEP00000023375	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily. (481 aa)
	ENSAPEP00000023621	Uncharacterized protein. (929 aa)
	ENSAPEP00000024456	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (613 aa)
	ENSAPEP00000025157	PDZ domain containing ring finger 4. (750 aa)
	ENSAPEP00000025888	TBD domain-containing protein. (341 aa)
	ENSAPEP00000029365	Im:7152348. (149 aa)
	ENSAPEP00000029489	RanBP-type and C3HC4-type zinc finger containing 1. (519 aa)
	ENSAPEP00000029717	Uncharacterized protein. (912 aa)
	ENSAPEP00000030359	Protein kinase domain-containing protein. (693 aa)
	ENSAPEP00000031067	Uncharacterized protein; Belongs to the peptidase C14A family. (487 aa)
	ENSAPEP00000032385	Optineurin. (536 aa)
	ENSAPEP00000032798	Sharpin and rbck1 related. (698 aa)
	ENSAPEP00000034279	Cylindromatosis (turban tumor syndrome), b. (707 aa)
	ENSAPEP00000034745	UBIQUITIN_CONJUGAT_2 domain-containing protein. (139 aa)

Your Current Organism:

Amphiprion percula

NCBI taxonomy Id: 161767
Other names: A. percula, Picasso clownfish, orange clownfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSAPEP00000000714	ENSAPEP00000005371	ENSAPEP00000000714	Component of inhibitor of nuclear factor kappa B kinase complex.	Pleckstrin homology domain containing, family G (with RhoGef domain) member 5b.	0.894
CHUK	ENSAPEP00000001423	ENSAPEP00000005371	ENSAPEP00000001423	Component of inhibitor of nuclear factor kappa B kinase complex.	Si:dkey-181m9.8.	0.733
CHUK	ENSAPEP00000002471	ENSAPEP00000005371	ENSAPEP00000002471	Component of inhibitor of nuclear factor kappa B kinase complex.	Mitogen-activated protein kinase kinase kinase 7.	0.966
CHUK	ENSAPEP00000003497	ENSAPEP00000005371	ENSAPEP00000003497	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.803
CHUK	ENSAPEP00000004292	ENSAPEP00000005371	ENSAPEP00000004292	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor.	0.764
CHUK	ENSAPEP00000005068	ENSAPEP00000005371	ENSAPEP00000005068	Component of inhibitor of nuclear factor kappa B kinase complex.	Tumor necrosis factor, alpha-induced protein 3.	0.745
CHUK	ENSAPEP00000005218	ENSAPEP00000005371	ENSAPEP00000005218	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.948
CHUK	ENSAPEP00000005629	ENSAPEP00000005371	ENSAPEP00000005629	Component of inhibitor of nuclear factor kappa B kinase complex.	SHANK-associated RH domain interacting protein.	0.685
CHUK	ENSAPEP00000005826	ENSAPEP00000005371	ENSAPEP00000005826	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.956
CHUK	ENSAPEP00000006542	ENSAPEP00000005371	ENSAPEP00000006542	Component of inhibitor of nuclear factor kappa B kinase complex.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.954
CHUK	ENSAPEP00000009615	ENSAPEP00000005371	ENSAPEP00000009615	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.933
CHUK	ENSAPEP00000009947	ENSAPEP00000005371	ENSAPEP00000009947	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.457
CHUK	ENSAPEP00000010222	ENSAPEP00000005371	ENSAPEP00000010222	Component of inhibitor of nuclear factor kappa B kinase complex.	BCL3 transcription coactivator.	0.856
CHUK	ENSAPEP00000011639	ENSAPEP00000005371	ENSAPEP00000011639	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.733
CHUK	ENSAPEP00000012137	ENSAPEP00000005371	ENSAPEP00000012137	Component of inhibitor of nuclear factor kappa B kinase complex.	TGF-beta activated kinase 1/MAP3K7 binding protein 1.	0.955
CHUK	ENSAPEP00000012208	ENSAPEP00000005371	ENSAPEP00000012208	Component of inhibitor of nuclear factor kappa B kinase complex.	Baculoviral IAP repeat containing 7.	0.744
CHUK	ENSAPEP00000014341	ENSAPEP00000005371	ENSAPEP00000014341	Component of inhibitor of nuclear factor kappa B kinase complex.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.753
CHUK	ENSAPEP00000014398	ENSAPEP00000005371	ENSAPEP00000014398	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor.	0.740
CHUK	ENSAPEP00000016413	ENSAPEP00000005371	ENSAPEP00000016413	Component of inhibitor of nuclear factor kappa B kinase complex.	Tumor necrosis factor receptor superfamily, member 1a.	0.894
CHUK	ENSAPEP00000018676	ENSAPEP00000005371	ENSAPEP00000018676	Component of inhibitor of nuclear factor kappa B kinase complex.	Tnfrsf1a-associated via death domain.	0.882