(37 nodes) Negative regulation of cytokine-mediated signaling pathway network (Amphiprion percula)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	ENSAPEP00000010598	HD_domain domain-containing protein. (529 aa)
	ENSAPEP00000001434	Ring finger protein 113A. (322 aa)
	OTOP1	Otopetrin 1. (596 aa)
	ENSAPEP00000002847	Uncharacterized protein. (430 aa)
	ENSAPEP00000004065	Uncharacterized protein. (497 aa)
	ENSAPEP00000006644	Adenosine deaminase RNA specific. (1338 aa)
	ENSAPEP00000008590	Poly [ADP-ribose] polymerase. (1813 aa)
	ENSAPEP00000008735	Coiled-coil domain containing 3b. (275 aa)
	ENSAPEP00000009283	Methyltransferase like 3; Belongs to the MT-A70-like family. (592 aa)
	ENSAPEP00000009660	Protein inhibitor of activated STAT, 4a. (497 aa)
	ENSAPEP00000010000	Protein tyrosine phosphatase receptor type C. (1264 aa)
	ENSAPEP00000010016	Nuclear receptor subfamily 1, group H, member 4. (485 aa)
	ENSAPEP00000030718	Uncharacterized protein. (512 aa)
	ENSAPEP00000030963	Uncharacterized protein. (118 aa)
	ENSAPEP00000031403	Uncharacterized protein. (648 aa)
	ENSAPEP00000032372	Coiled-coil domain containing 3a. (282 aa)
	ENSAPEP00000032541	TRAF-interacting protein. (444 aa)
	ENSAPEP00000032605	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain. (523 aa)
	ENSAPEP00000033448	Tubulin tyrosine ligase-like family, member 12. (633 aa)
	ENSAPEP00000034094	Uncharacterized protein. (235 aa)
	ENSAPEP00000034279	Cylindromatosis (turban tumor syndrome), b. (707 aa)
	ENSAPEP00000034635	RAB guanine nucleotide exchange factor (GEF) 1, like. (507 aa)
	ENSAPEP00000034787	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	ENSAPEP00000010618	SAM domain and HD domain 1. (626 aa)
	ENSAPEP00000012264	Nuclear receptor subfamily 1, group H, member 5. (488 aa)
	ENSAPEP00000014341	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (956 aa)
	ENSAPEP00000016135	Uncharacterized protein. (393 aa)
	ENSAPEP00000019627	Uncharacterized protein. (897 aa)
	ENSAPEP00000019692	Uncharacterized protein. (1274 aa)
	ENSAPEP00000020104	Uncharacterized protein; Belongs to the MT-A70-like family. (406 aa)
	ENSAPEP00000023621	Uncharacterized protein. (929 aa)
	ENSAPEP00000023775	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (166 aa)
	ENSAPEP00000024832	YTH N(6)-methyladenosine RNA binding protein 2. (639 aa)
	ENSAPEP00000028257	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family. (754 aa)
	ENSAPEP00000028465	SH2B adaptor protein 3. (741 aa)
	ENSAPEP00000028650	YTH N(6)-methyladenosine RNA binding protein 3. (603 aa)
	ENSAPEP00000029583	DC-STAMP domain containing 1. (440 aa)

Your Current Organism:

Amphiprion percula

NCBI taxonomy Id: 161767
Other names: A. percula, Picasso clownfish, orange clownfish

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSAPEP00000006644	ENSAPEP00000010598	Adenosine deaminase RNA specific.	HD_domain domain-containing protein.	0.446
ENSAPEP00000006644	ENSAPEP00000010618	Adenosine deaminase RNA specific.	SAM domain and HD domain 1.	0.446
ENSAPEP00000006644	ENSAPEP00000023775	Adenosine deaminase RNA specific.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.477
ENSAPEP00000009660	ENSAPEP00000010016	Protein inhibitor of activated STAT, 4a.	Nuclear receptor subfamily 1, group H, member 4.	0.432
ENSAPEP00000009660	ENSAPEP00000012264	Protein inhibitor of activated STAT, 4a.	Nuclear receptor subfamily 1, group H, member 5.	0.432
ENSAPEP00000010000	ENSAPEP00000019627	Protein tyrosine phosphatase receptor type C.	Uncharacterized protein.	0.596
ENSAPEP00000010016	ENSAPEP00000009660	Nuclear receptor subfamily 1, group H, member 4.	Protein inhibitor of activated STAT, 4a.	0.432
ENSAPEP00000010598	ENSAPEP00000006644	HD_domain domain-containing protein.	Adenosine deaminase RNA specific.	0.446
ENSAPEP00000010618	ENSAPEP00000006644	SAM domain and HD domain 1.	Adenosine deaminase RNA specific.	0.446
ENSAPEP00000012264	ENSAPEP00000009660	Nuclear receptor subfamily 1, group H, member 5.	Protein inhibitor of activated STAT, 4a.	0.432
ENSAPEP00000014341	ENSAPEP00000023621	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.827
ENSAPEP00000014341	ENSAPEP00000028257	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family.	0.827
ENSAPEP00000014341	ENSAPEP00000034279	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Cylindromatosis (turban tumor syndrome), b.	0.834
ENSAPEP00000019627	ENSAPEP00000010000	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.596
ENSAPEP00000020104	ENSAPEP00000024832	Uncharacterized protein; Belongs to the MT-A70-like family.	YTH N(6)-methyladenosine RNA binding protein 2.	0.480
ENSAPEP00000020104	ENSAPEP00000028650	Uncharacterized protein; Belongs to the MT-A70-like family.	YTH N(6)-methyladenosine RNA binding protein 3.	0.478
ENSAPEP00000023621	ENSAPEP00000014341	Uncharacterized protein.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.827
ENSAPEP00000023621	ENSAPEP00000028257	Uncharacterized protein.	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family.	0.832
ENSAPEP00000023621	ENSAPEP00000034279	Uncharacterized protein.	Cylindromatosis (turban tumor syndrome), b.	0.832
ENSAPEP00000023775	ENSAPEP00000006644	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Adenosine deaminase RNA specific.	0.477