(29 nodes) CD4-positive, alpha-beta T cell activation network (Amphiprion percula)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSAPEP00000007921	E3 ubiquitin-protein ligase. (889 aa)
	ENSAPEP00000000439	Armadillo repeat containing 5. (1262 aa)
	ENSAPEP00000002540	Basic leucine zipper transcription factor, ATF-like. (124 aa)
	ENSAPEP00000002831	Transmembrane protein 98. (224 aa)
	ENSAPEP00000004354	Fibronectin type-III domain-containing protein. (568 aa)
	ENSAPEP00000004486	Ig-like domain-containing protein. (251 aa)
	ENSAPEP00000005822	Si:ch211-184m13.4; Belongs to the G-protein coupled receptor 1 family. (346 aa)
	ENSAPEP00000005835	G protein-coupled receptor 183a; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	ENSAPEP00000005940	Stomatin (EPB72)-like 2. (355 aa)
	ENSAPEP00000006587	Receptor-interacting serine-threonine kinase 2. (587 aa)
	ENSAPEP00000007055	T-box transcription factor 21. (618 aa)
	ENSAPEP00000008686	SAM and SH3 domain containing 3. (397 aa)
	ENSAPEP00000009494	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	ENSAPEP00000010798	Ring finger and CCCH-type domains 2. (1153 aa)
	ENSAPEP00000011861	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2516 aa)
	ENSAPEP00000011998	Ring finger and CCCH-type domains 1b. (1132 aa)
	NKX2-3	NK2 homeobox 3. (351 aa)
	ENSAPEP00000014195	H2.0-like homeo box 1 (Drosophila). (376 aa)
	ENSAPEP00000014824	E3 ubiquitin-protein ligase. (868 aa)
	ENSAPEP00000015291	Caspase recruitment domain family, member 11. (1165 aa)
	IL12B-2	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (355 aa)
	ENSAPEP00000019471	Cadherin 26, tandem duplicate 1; Cadherins are calcium-dependent cell adhesion proteins. (832 aa)
	ENSAPEP00000019768	Lymphoid enhancer-binding factor 1. (362 aa)
	ENSAPEP00000020118	NK2 homeobox 3. (342 aa)
	ENSAPEP00000021525	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (484 aa)
	ENSAPEP00000023042	Uncharacterized protein. (227 aa)
	ENSAPEP00000024205	Fibronectin type-III domain-containing protein. (313 aa)
	ENSAPEP00000032330	Prostaglandin E receptor 4 (subtype EP4) b. (468 aa)
	ENSAPEP00000033267	Uncharacterized protein. (484 aa)

Your Current Organism:

Amphiprion percula

NCBI taxonomy Id: 161767
Other names: A. percula, Picasso clownfish, orange clownfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPEP00000002540	ENSAPEP00000007055	ENSAPEP00000002540	ENSAPEP00000007055	Basic leucine zipper transcription factor, ATF-like.	T-box transcription factor 21.	0.447
ENSAPEP00000004354	ENSAPEP00000024205	ENSAPEP00000004354	ENSAPEP00000024205	Fibronectin type-III domain-containing protein.	Fibronectin type-III domain-containing protein.	0.832
ENSAPEP00000004354	IL12B-2	ENSAPEP00000004354	ENSAPEP00000016214	Fibronectin type-III domain-containing protein.	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	0.594
ENSAPEP00000006587	ENSAPEP00000007921	ENSAPEP00000006587	ENSAPEP00000007921	Receptor-interacting serine-threonine kinase 2.	E3 ubiquitin-protein ligase.	0.719
ENSAPEP00000006587	ENSAPEP00000011861	ENSAPEP00000006587	ENSAPEP00000011861	Receptor-interacting serine-threonine kinase 2.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.419
ENSAPEP00000006587	ENSAPEP00000014824	ENSAPEP00000006587	ENSAPEP00000014824	Receptor-interacting serine-threonine kinase 2.	E3 ubiquitin-protein ligase.	0.719
ENSAPEP00000006587	ENSAPEP00000015291	ENSAPEP00000006587	ENSAPEP00000015291	Receptor-interacting serine-threonine kinase 2.	Caspase recruitment domain family, member 11.	0.714
ENSAPEP00000007055	ENSAPEP00000002540	ENSAPEP00000007055	ENSAPEP00000002540	T-box transcription factor 21.	Basic leucine zipper transcription factor, ATF-like.	0.447
ENSAPEP00000007055	ENSAPEP00000014195	ENSAPEP00000007055	ENSAPEP00000014195	T-box transcription factor 21.	H2.0-like homeo box 1 (Drosophila).	0.563
ENSAPEP00000007055	ENSAPEP00000019768	ENSAPEP00000007055	ENSAPEP00000019768	T-box transcription factor 21.	Lymphoid enhancer-binding factor 1.	0.479
ENSAPEP00000007921	ENSAPEP00000006587	ENSAPEP00000007921	ENSAPEP00000006587	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.719
ENSAPEP00000007921	ENSAPEP00000014824	ENSAPEP00000007921	ENSAPEP00000014824	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.897
ENSAPEP00000007921	ENSAPEP00000019768	ENSAPEP00000007921	ENSAPEP00000019768	E3 ubiquitin-protein ligase.	Lymphoid enhancer-binding factor 1.	0.440
ENSAPEP00000008686	ENSAPEP00000024205	ENSAPEP00000008686	ENSAPEP00000024205	SAM and SH3 domain containing 3.	Fibronectin type-III domain-containing protein.	0.447
ENSAPEP00000010798	ENSAPEP00000011998	ENSAPEP00000010798	ENSAPEP00000011998	Ring finger and CCCH-type domains 2.	Ring finger and CCCH-type domains 1b.	0.836
ENSAPEP00000011861	ENSAPEP00000006587	ENSAPEP00000011861	ENSAPEP00000006587	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	Receptor-interacting serine-threonine kinase 2.	0.419
ENSAPEP00000011998	ENSAPEP00000010798	ENSAPEP00000011998	ENSAPEP00000010798	Ring finger and CCCH-type domains 1b.	Ring finger and CCCH-type domains 2.	0.836
ENSAPEP00000014195	ENSAPEP00000007055	ENSAPEP00000014195	ENSAPEP00000007055	H2.0-like homeo box 1 (Drosophila).	T-box transcription factor 21.	0.563
ENSAPEP00000014824	ENSAPEP00000006587	ENSAPEP00000014824	ENSAPEP00000006587	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.719
ENSAPEP00000014824	ENSAPEP00000007921	ENSAPEP00000014824	ENSAPEP00000007921	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.897