(45 nodes) Ribosome assembly network (Amphiprion percula)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSAPEP00000033036	Ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family. (155 aa)
	EFL1	Elongation factor like GTPase 1. (1131 aa)
	ENSAPEP00000002947	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28. (572 aa)
	ENSAPEP00000003902	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (180 aa)
	ENSAPEP00000005618	Ribosome production factor 2 homolog. (308 aa)
	ENSAPEP00000005678	40S ribosomal protein S27. (84 aa)
	ENSAPEP00000006196	DEAH (Asp-Glu-Ala-His) box helicase 30. (1098 aa)
	ENSAPEP00000006521	FAST kinase domains 2. (688 aa)
	ENSAPEP00000006815	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (235 aa)
	ENSAPEP00000008564	MPV17 mitochondrial membrane protein-like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family. (218 aa)
	ENSAPEP00000008778	Mitochondrial ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family. (206 aa)
	ENSAPEP00000009181	Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family. (195 aa)
	ENSAPEP00000011479	PWP2 small subunit processome component. (908 aa)
	ENSAPEP00000011615	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3892 aa)
	ENSAPEP00000012581	40S ribosomal protein S27. (93 aa)
	ENSAPEP00000013219	Mitochondrial ribosomal protein S7. (229 aa)
	MTERF4	Mitochondrial transcription termination factor 4. (355 aa)
	ENSAPEP00000014098	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (187 aa)
	ENSAPEP00000015800	NOP2 nucleolar protein homolog (yeast); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (722 aa)
	ENSAPEP00000016833	Mitochondrial transcription termination factor 3. (431 aa)
	ENSAPEP00000018943	Complement component 1, q subcomponent binding protein. (241 aa)
	ENSAPEP00000019194	Ribosomal RNA processing 7 homolog A. (282 aa)
	ENSAPEP00000019673	Mitochondrial ribosomal protein L20; Belongs to the bacterial ribosomal protein bL20 family. (149 aa)
	RPL5	Ribosomal protein L5. (298 aa)
	ENSAPEP00000021671	Era-like 12S mitochondrial rRNA chaperone 1. (450 aa)
	ENSAPEP00000022132	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (723 aa)
	ENSAPEP00000022310	SBDS ribosome maturation factor. (249 aa)
	RPSA	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Belongs to the universal ribosomal protein uS2 family. (301 aa)
	ENSAPEP00000023156	Mitochondrial rRNA methyltransferase 2. (239 aa)
	ENSAPEP00000024102	Brix domain containing 2. (342 aa)
	ENSAPEP00000024358	Ribosomal protein L6. (258 aa)
	ENSAPEP00000024713	DEAH (Asp-Glu-Ala-His) box polypeptide 37. (1138 aa)
	ENSAPEP00000025201	Ribosomal protein L10. (215 aa)
	ENSAPEP00000026058	TNF receptor-associated factor 7. (654 aa)
	ENSAPEP00000027397	40S ribosomal protein S27. (93 aa)
	DHX29	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1386 aa)
	ENSAPEP00000028676	Neugrin, neurite outgrowth associated. (306 aa)
	ENSAPEP00000030922	Coiled-coil domain containing 105. (444 aa)
	ENSAPEP00000032045	UPF0113_N domain-containing protein. (76 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (246 aa)
	ENSAPEP00000032554	Notchless homolog 1 (Drosophila). (478 aa)
	ENSAPEP00000032697	Uncharacterized protein. (88 aa)
	ENSAPEP00000033255	Activator of basal transcription 1. (319 aa)
	RPL5-2	Ribosomal protein L5b. (298 aa)
	ENSAPEP00000034594	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (462 aa)

Your Current Organism:

Amphiprion percula

NCBI taxonomy Id: 161767
Other names: A. percula, Picasso clownfish, orange clownfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHX29	EFL1	ENSAPEP00000027402	ENSAPEP00000000358	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	Elongation factor like GTPase 1.	0.453
DHX29	ENSAPEP00000002947	ENSAPEP00000027402	ENSAPEP00000002947	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28.	0.582
DHX29	ENSAPEP00000003902	ENSAPEP00000027402	ENSAPEP00000003902	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.	0.517
DHX29	ENSAPEP00000005678	ENSAPEP00000027402	ENSAPEP00000005678	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	40S ribosomal protein S27.	0.483
DHX29	ENSAPEP00000009181	ENSAPEP00000027402	ENSAPEP00000009181	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family.	0.640
DHX29	ENSAPEP00000011479	ENSAPEP00000027402	ENSAPEP00000011479	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	PWP2 small subunit processome component.	0.714
DHX29	ENSAPEP00000012581	ENSAPEP00000027402	ENSAPEP00000012581	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	40S ribosomal protein S27.	0.483
DHX29	ENSAPEP00000013219	ENSAPEP00000027402	ENSAPEP00000013219	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	Mitochondrial ribosomal protein S7.	0.494
DHX29	ENSAPEP00000014098	ENSAPEP00000027402	ENSAPEP00000014098	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family.	0.528
DHX29	ENSAPEP00000019194	ENSAPEP00000027402	ENSAPEP00000019194	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	Ribosomal RNA processing 7 homolog A.	0.783
DHX29	ENSAPEP00000027397	ENSAPEP00000027402	ENSAPEP00000027397	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	40S ribosomal protein S27.	0.483
DHX29	ENSAPEP00000030922	ENSAPEP00000027402	ENSAPEP00000030922	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	Coiled-coil domain containing 105.	0.483
DHX29	ENSAPEP00000032045	ENSAPEP00000027402	ENSAPEP00000032045	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	UPF0113_N domain-containing protein.	0.517
DHX29	ENSAPEP00000032697	ENSAPEP00000027402	ENSAPEP00000032697	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	Uncharacterized protein.	0.483
DHX29	ENSAPEP00000033255	ENSAPEP00000027402	ENSAPEP00000033255	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	Activator of basal transcription 1.	0.508
DHX29	RPSA	ENSAPEP00000027402	ENSAPEP00000022891	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Belongs to the universal ribosomal protein uS2 family.	0.417
EFL1	DHX29	ENSAPEP00000000358	ENSAPEP00000027402	Elongation factor like GTPase 1.	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	0.453
EFL1	EIF6	ENSAPEP00000000358	ENSAPEP00000032369	Elongation factor like GTPase 1.	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	0.904
EFL1	ENSAPEP00000002947	ENSAPEP00000000358	ENSAPEP00000002947	Elongation factor like GTPase 1.	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28.	0.582
EFL1	ENSAPEP00000005678	ENSAPEP00000000358	ENSAPEP00000005678	Elongation factor like GTPase 1.	40S ribosomal protein S27.	0.782