(72 nodes) Positive regulation of lipid metabolic process network (Amphiprion percula)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSAPEP00000012509	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (425 aa)
	GH	Growth hormone 1. (204 aa)
	ENSAPEP00000013028	Phospholipase A2, group VI (cytosolic, calcium-independent). (801 aa)
	ENSAPEP00000013289	ATP-binding cassette, sub-family D (ALD), member 2. (737 aa)
	ENSAPEP00000013859	Coagulation factor II (thrombin); Belongs to the peptidase S1 family. (587 aa)
	ENSAPEP00000013911	Sterol regulatory element binding transcription factor 1. (1177 aa)
	ENSAPEP00000014467	Nuclear receptor subfamily 1, group D, member 4b. (566 aa)
	ENSAPEP00000014468	Insulin-like growth factor 2b. (215 aa)
	ENSAPEP00000014648	Abhydrolase domain containing 6b. (338 aa)
	ENSAPEP00000014913	CTD nuclear envelope phosphatase 1 regulatory subunit 1. (140 aa)
	ENSAPEP00000016039	PNPLA domain-containing protein. (430 aa)
	ENSAPEP00000016144	Angiopoietin-like 3. (472 aa)
	ENSAPEP00000016321	Interleukin-1; Belongs to the IL-1 family. (259 aa)
	ENSAPEP00000016851	Cellular communication network factor 1. (376 aa)
	ENSAPEP00000018848	Sterol regulatory element binding transcription factor 2. (1181 aa)
	ENSAPEP00000018869	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (310 aa)
	ENSAPEP00000019102	Adhesion G protein-coupled receptor F7; Belongs to the G-protein coupled receptor 2 family. (468 aa)
	ENSAPEP00000019130	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (477 aa)
	ENSAPEP00000019764	CTD nuclear envelope phosphatase 1b. (245 aa)
	ENSAPEP00000027890	Zgc:153896. (437 aa)
	ENSAPEP00000027540	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a. (492 aa)
	ENSAPEP00000027157	Peroxisome proliferator-activated receptor delta b. (439 aa)
	ENSAPEP00000027001	SCY domain-containing protein. (111 aa)
	ENPP7	Ectonucleotide pyrophosphatase/phosphodiesterase 7. (442 aa)
	ENSAPEP00000026631	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (153 aa)
	ENSAPEP00000025330	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (182 aa)
	ENSAPEP00000025316	Uncharacterized protein. (968 aa)
	ENSAPEP00000022523	Ectonucleotide pyrophosphatase/phosphodiesterase 7, tandem duplicate 2. (507 aa)
	ENSAPEP00000021379	Transforming growth factor beta; Belongs to the TGF-beta family. (384 aa)
	DISP3	Dispatched RND transporter family member 3. (820 aa)
	ENSAPEP00000020909	Peroxisome proliferator-activated receptor alpha a. (482 aa)
	ENSAPEP00000003613	Lysophosphatidylglycerol acyltransferase 1. (372 aa)
	ENSAPEP00000010795	Scavenger receptor class B, member 1; Belongs to the CD36 family. (518 aa)
	ENSAPEP00000003532	Autophagy/beclin-1 regulator 1b. (1385 aa)
	ENSAPEP00000002734	ATP-binding cassette, sub-family G (WHITE), member 4a. (639 aa)
	MTLN	Mitoregulin. (56 aa)
	ENSAPEP00000005936	Uncharacterized protein. (1540 aa)
	ENSAPEP00000005940	Stomatin (EPB72)-like 2. (355 aa)
	PPARG	Peroxisome proliferator activated receptor gamma. (567 aa)
	ENSAPEP00000007297	PNPLA domain-containing protein. (261 aa)
	ENSAPEP00000007375	ABC transporter domain-containing protein. (652 aa)
	ENSAPEP00000009337	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (428 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (469 aa)
	ENSAPEP00000009648	Solute carrier family 27 member 1a. (648 aa)
	ENSAPEP00000010016	Nuclear receptor subfamily 1, group H, member 4. (485 aa)
	ENSAPEP00000030371	annotation not available (260 aa)
	ENSAPEP00000029233	Apolipoprotein Ea. (260 aa)
	ENSAPEP00000028830	Phosphoinositide-3-kinase, regulatory subunit 4. (1345 aa)
	ENSAPEP00000028473	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (147 aa)
	ENSAPEP00000000133	Nuclear receptor subfamily 1, group H, member 3. (461 aa)
	ENSAPEP00000000273	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (353 aa)
	ENSAPEP00000000990	Zinc finger and BTB domain containing 20. (680 aa)
	ENSAPEP00000001230	ATP-binding cassette, sub-family G (WHITE), member 1. (636 aa)
	ENSAPEP00000001304	Malonyl-CoA decarboxylase. (498 aa)
	ENSAPEP00000002040	Fibrinogen C-terminal domain-containing protein. (480 aa)
	ENSAPEP00000002067	DAB adaptor protein 2. (582 aa)
	ENSAPEP00000002079	SREBF chaperone. (1357 aa)
	ATG14	Autophagy related 14. (508 aa)
	ENSAPEP00000002609	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (472 aa)
	ENSAPEP00000003958	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (566 aa)
	ENSAPEP00000012481	Prostaglandin-endoperoxide synthase 2b. (608 aa)
	ENSAPEP00000012705	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (135 aa)
	ENSAPEP00000034930	Tumor necrosis factor, alpha-induced protein 8-like 3. (202 aa)
	ENSAPEP00000034849	cAMP responsive element binding protein-like 2. (122 aa)
	ENSAPEP00000034094	Uncharacterized protein. (235 aa)
	ENSAPEP00000033286	Patatin-like phospholipase domain containing 3. (472 aa)
	ENSAPEP00000033229	Abhydrolase domain containing 6. (337 aa)
	ENSAPEP00000032867	Podocan. (593 aa)
	ENSAPEP00000031294	Patatin-like phospholipase domain containing 2. (511 aa)
	ENSAPEP00000011219	Nuclear receptor subfamily 1, group d, member 1. (613 aa)
	ENSAPEP00000011861	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2516 aa)
	ENSAPEP00000012264	Nuclear receptor subfamily 1, group H, member 5. (488 aa)

Your Current Organism:

Amphiprion percula

NCBI taxonomy Id: 161767
Other names: A. percula, Picasso clownfish, orange clownfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG14	ENSAPEP00000003532	ENSAPEP00000002126	ENSAPEP00000003532	Autophagy related 14.	Autophagy/beclin-1 regulator 1b.	0.921
ATG14	ENSAPEP00000011861	ENSAPEP00000002126	ENSAPEP00000011861	Autophagy related 14.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.407
ATG14	ENSAPEP00000028830	ENSAPEP00000002126	ENSAPEP00000028830	Autophagy related 14.	Phosphoinositide-3-kinase, regulatory subunit 4.	0.999
ENPP7	ENSAPEP00000000273	ENSAPEP00000026994	ENSAPEP00000000273	Ectonucleotide pyrophosphatase/phosphodiesterase 7.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.504
ENPP7	ENSAPEP00000009337	ENSAPEP00000026994	ENSAPEP00000009337	Ectonucleotide pyrophosphatase/phosphodiesterase 7.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.504
ENPP7	ENSAPEP00000013028	ENSAPEP00000026994	ENSAPEP00000013028	Ectonucleotide pyrophosphatase/phosphodiesterase 7.	Phospholipase A2, group VI (cytosolic, calcium-independent).	0.567
ENPP7	ENSAPEP00000018869	ENSAPEP00000026994	ENSAPEP00000018869	Ectonucleotide pyrophosphatase/phosphodiesterase 7.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.566
ENPP7	ENSAPEP00000022523	ENSAPEP00000026994	ENSAPEP00000022523	Ectonucleotide pyrophosphatase/phosphodiesterase 7.	Ectonucleotide pyrophosphatase/phosphodiesterase 7, tandem duplicate 2.	0.898
ENPP7	ENSAPEP00000027890	ENSAPEP00000026994	ENSAPEP00000027890	Ectonucleotide pyrophosphatase/phosphodiesterase 7.	Zgc:153896.	0.899
ENSAPEP00000000133	ENSAPEP00000001230	ENSAPEP00000000133	ENSAPEP00000001230	Nuclear receptor subfamily 1, group H, member 3.	ATP-binding cassette, sub-family G (WHITE), member 1.	0.632
ENSAPEP00000000133	ENSAPEP00000002734	ENSAPEP00000000133	ENSAPEP00000002734	Nuclear receptor subfamily 1, group H, member 3.	ATP-binding cassette, sub-family G (WHITE), member 4a.	0.468
ENSAPEP00000000133	ENSAPEP00000007375	ENSAPEP00000000133	ENSAPEP00000007375	Nuclear receptor subfamily 1, group H, member 3.	ABC transporter domain-containing protein.	0.468
ENSAPEP00000000133	ENSAPEP00000011219	ENSAPEP00000000133	ENSAPEP00000011219	Nuclear receptor subfamily 1, group H, member 3.	Nuclear receptor subfamily 1, group d, member 1.	0.405
ENSAPEP00000000133	ENSAPEP00000011861	ENSAPEP00000000133	ENSAPEP00000011861	Nuclear receptor subfamily 1, group H, member 3.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.423
ENSAPEP00000000133	ENSAPEP00000013911	ENSAPEP00000000133	ENSAPEP00000013911	Nuclear receptor subfamily 1, group H, member 3.	Sterol regulatory element binding transcription factor 1.	0.620
ENSAPEP00000000133	ENSAPEP00000014467	ENSAPEP00000000133	ENSAPEP00000014467	Nuclear receptor subfamily 1, group H, member 3.	Nuclear receptor subfamily 1, group D, member 4b.	0.405
ENSAPEP00000000133	ENSAPEP00000018848	ENSAPEP00000000133	ENSAPEP00000018848	Nuclear receptor subfamily 1, group H, member 3.	Sterol regulatory element binding transcription factor 2.	0.561
ENSAPEP00000000133	ENSAPEP00000020909	ENSAPEP00000000133	ENSAPEP00000020909	Nuclear receptor subfamily 1, group H, member 3.	Peroxisome proliferator-activated receptor alpha a.	0.430
ENSAPEP00000000133	PPARA	ENSAPEP00000000133	ENSAPEP00000009647	Nuclear receptor subfamily 1, group H, member 3.	Peroxisome proliferator-activated receptor alpha b.	0.634
ENSAPEP00000000133	PPARG	ENSAPEP00000000133	ENSAPEP00000006947	Nuclear receptor subfamily 1, group H, member 3.	Peroxisome proliferator activated receptor gamma.	0.756