(108 nodes) Response to steroid hormone network (Amphiprion percula)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSAPEP00000020569	Death-domain associated protein. (733 aa)
	ENSAPEP00000020209	Inhibitor_Mig-6 domain-containing protein. (345 aa)
	ENSAPEP00000020137	Aspartate aminotransferase. (414 aa)
	ENSAPEP00000020070	Glutamic-oxaloacetic transaminase 1 like 1. (399 aa)
	PAQR8	Progestin and adipoQ receptor family member 8. (359 aa)
	RXRB	Retinoid X receptor beta. (470 aa)
	ENSAPEP00000019214	Peptidylglycine alpha-amidating monooxygenase. (975 aa)
	ENSAPEP00000018855	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	ENSAPEP00000018471	Retinoid x receptor, beta b. (444 aa)
	ENSAPEP00000018187	Urotensin 1. (148 aa)
	ENSAPEP00000018018	Uncharacterized protein; Belongs to the DEAD box helicase family. (650 aa)
	ENSAPEP00000017612	Progesterone receptor. (658 aa)
	ENSAPEP00000017522	Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	ESRRB	Estrogen-related receptor beta. (454 aa)
	ENSAPEP00000000068	Uncharacterized protein. (344 aa)
	PDCD7	Programmed cell death 7. (531 aa)
	ENSAPEP00000000596	Abhydrolase domain containing 2a. (431 aa)
	ENSAPEP00000000658	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
	ENSAPEP00000000843	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family. (366 aa)
	ENSAPEP00000001035	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (524 aa)
	ENSAPEP00000001143	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (525 aa)
	ENSAPEP00000001279	TATA element modulatory factor 1. (1153 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (405 aa)
	ENSAPEP00000001587	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (259 aa)
	ENSAPEP00000001595	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (261 aa)
	ENSAPEP00000001747	Tyrosine-protein kinase. (552 aa)
	ENSAPEP00000002067	DAB adaptor protein 2. (582 aa)
	ENSAPEP00000002464	Uncharacterized protein. (435 aa)
	ENSAPEP00000002509	Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
	ENSAPEP00000002828	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (937 aa)
	ENSAPEP00000003052	Somatostatin receptor 1a; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	ENSAPEP00000003065	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (495 aa)
	ENSAPEP00000003377	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (780 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (635 aa)
	ENSAPEP00000004246	Estrogen receptor 2b. (567 aa)
	ENSAPEP00000004405	Somatostatin receptor 2b; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	ENSAPEP00000004597	Estrogen-related receptor gamma a. (460 aa)
	ENSAPEP00000004799	Prohibitin. (281 aa)
	ENSAPEP00000005035	Thyroid hormone receptor interactor 4. (572 aa)
	ENSAPEP00000005845	SET and MYND domain containing 3. (436 aa)
	ENSAPEP00000006317	ERBB receptor feedback inhibitor 1a. (438 aa)
	ENSAPEP00000006523	Aconitate decarboxylase 1. (484 aa)
	ENSAPEP00000006527	Transforming growth factor, beta 2. (271 aa)
	ENSAPEP00000006781	Progestin and adipoQ receptor family member VII, a. (345 aa)
	ENSAPEP00000007035	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (537 aa)
	ENSAPEP00000007057	Tissue factor pathway inhibitor. (287 aa)
	ENSAPEP00000007114	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	ENSAPEP00000007564	RWD domain containing 1. (240 aa)
	ENSAPEP00000008623	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (474 aa)
	ENSAPEP00000008792	BCL2 apoptosis regulator b. (228 aa)
	ENSAPEP00000008904	Estrogen receptor 2a. (559 aa)
	TFAP4	Transcription factor AP-4. (369 aa)
	ENSAPEP00000009415	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (392 aa)
	ENSAPEP00000009572	Zinc finger protein 36, C3H type-like 2. (429 aa)
	ENSAPEP00000009596	Transcription factor AP-4 (activating enhancer binding protein 4). (332 aa)
	ENSAPEP00000010179	Androgen receptor. (759 aa)
	ENSAPEP00000010190	Interleukin 10. (187 aa)
	ENSAPEP00000010522	Apoptosis inducing factor mitochondrion associated 1. (831 aa)
	ENSAPEP00000011181	Ubiquitin protein ligase E3 component n-recognin 5. (2511 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (893 aa)
	ENSAPEP00000012012	Si:zfos-169g10.2; Belongs to the G-protein coupled receptor 1 family. (426 aa)
	ENSAPEP00000012407	FOS-like antigen 1a. (347 aa)
	ENSAPEP00000012737	Growth differentiation factor 11. (388 aa)
	ENSAPEP00000012982	Estrogen-related receptor alpha. (433 aa)
	ENSAPEP00000013108	Transforming growth factor beta; Belongs to the TGF-beta family. (425 aa)
	ENSAPEP00000013699	Phosphoenolpyruvate carboxykinase 2 (mitochondrial). (635 aa)
	GOT1	Aspartate aminotransferase. (410 aa)
	ENSAPEP00000014166	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (440 aa)
	ENSAPEP00000014362	Zinc finger protein 36, C3H type-like 1a. (372 aa)
	ENSAPEP00000014406	Uncharacterized protein. (691 aa)
	ENSAPEP00000015461	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (401 aa)
	ENSAPEP00000015888	Tyrosine-protein kinase. (439 aa)
	ENSAPEP00000016531	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
	ENSAPEP00000016710	Somatostatin receptor 1b; Belongs to the G-protein coupled receptor 1 family. (408 aa)
	ABHD2	Abhydrolase domain containing 2b. (438 aa)
	ENSAPEP00000017127	URI1 prefoldin like chaperone. (495 aa)
	ENSAPEP00000034953	BH4_2 domain-containing protein. (212 aa)
	ENSAPEP00000034889	Ubiquitin carboxyl-terminal hydrolase. (904 aa)
	ENSAPEP00000034739	Uncharacterized protein. (228 aa)
	ENSAPEP00000034081	Uncharacterized protein. (465 aa)
	ENSAPEP00000033003	Fin bud initiation factor a. (209 aa)
	ENSAPEP00000031572	Sb:cb81. (376 aa)
	ENSAPEP00000031515	Phosphoenolpyruvate carboxykinase 1 (soluble). (624 aa)
	ENSAPEP00000029479	P/Homo B domain-containing protein. (568 aa)
	ENSAPEP00000028512	Branched chain keto acid dehydrogenase E1 subunit beta. (369 aa)
	ENSAPEP00000027585	Somatostatin receptor 2a; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	ENSAPEP00000027409	Ubiquitin protein ligase E3A. (852 aa)
	ENSAPEP00000027349	Uncharacterized protein. (341 aa)
	ENSAPEP00000026667	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (782 aa)
	ENSAPEP00000026034	Progestin and adipoQ receptor family member VII, b. (352 aa)
	DDX17	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (648 aa)
	GPR83	G protein-coupled receptor 83. (431 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (792 aa)
	ENSAPEP00000025173	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (374 aa)
	ENSAPEP00000024812	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	ENSAPEP00000024141	annotation not available (479 aa)
	ENSAPEP00000023775	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (166 aa)
	ENSAPEP00000023290	Carboxypeptidase N, polypeptide 1. (448 aa)
	ENSAPEP00000023084	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (613 aa)
	ENSAPEP00000021899	NK3 homeobox 1. (194 aa)
	ENSAPEP00000021851	Spermatogenesis associated 18. (479 aa)
	ENSAPEP00000021700	Zgc:162730. (406 aa)
	ENSAPEP00000021513	Protein kinase domain-containing protein. (338 aa)
	ENSAPEP00000021495	Retinoid X receptor, alpha a. (496 aa)
	ENSAPEP00000021379	Transforming growth factor beta; Belongs to the TGF-beta family. (384 aa)
	ENSAPEP00000021219	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1827 aa)
	ENSAPEP00000020642	Immunoresponsive gene 1, like. (495 aa)
	ENSAPEP00000020553	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family. (616 aa)

Your Current Organism:

Amphiprion percula

NCBI taxonomy Id: 161767
Other names: A. percula, Picasso clownfish, orange clownfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX17	ENSAPEP00000000658	ENSAPEP00000025803	ENSAPEP00000000658	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.	0.442
DDX17	ENSAPEP00000004246	ENSAPEP00000025803	ENSAPEP00000004246	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Estrogen receptor 2b.	0.717
DDX17	ENSAPEP00000008904	ENSAPEP00000025803	ENSAPEP00000008904	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Estrogen receptor 2a.	0.717
DDX17	ENSAPEP00000014166	ENSAPEP00000025803	ENSAPEP00000014166	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	0.442
DDX17	ENSAPEP00000021513	ENSAPEP00000025803	ENSAPEP00000021513	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Protein kinase domain-containing protein.	0.442
DDX17	ENSAPEP00000023084	ENSAPEP00000025803	ENSAPEP00000023084	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.717
DDX5	ENSAPEP00000000658	ENSAPEP00000004025	ENSAPEP00000000658	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.	0.442
DDX5	ENSAPEP00000004246	ENSAPEP00000004025	ENSAPEP00000004246	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor 2b.	0.717
DDX5	ENSAPEP00000008904	ENSAPEP00000004025	ENSAPEP00000008904	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor 2a.	0.717
DDX5	ENSAPEP00000014166	ENSAPEP00000004025	ENSAPEP00000014166	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	0.442
DDX5	ENSAPEP00000020553	ENSAPEP00000004025	ENSAPEP00000020553	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family.	0.897
DDX5	ENSAPEP00000021513	ENSAPEP00000004025	ENSAPEP00000021513	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Protein kinase domain-containing protein.	0.442
DDX5	ENSAPEP00000023084	ENSAPEP00000004025	ENSAPEP00000023084	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.717
ENSAPEP00000000658	DDX17	ENSAPEP00000000658	ENSAPEP00000025803	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.442
ENSAPEP00000000658	DDX5	ENSAPEP00000000658	ENSAPEP00000004025	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.442
ENSAPEP00000000658	ENSAPEP00000001747	ENSAPEP00000000658	ENSAPEP00000001747	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.428
ENSAPEP00000000658	ENSAPEP00000002509	ENSAPEP00000000658	ENSAPEP00000002509	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.457
ENSAPEP00000000658	ENSAPEP00000010190	ENSAPEP00000000658	ENSAPEP00000010190	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.	Interleukin 10.	0.405
ENSAPEP00000000658	ENSAPEP00000012407	ENSAPEP00000000658	ENSAPEP00000012407	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.	FOS-like antigen 1a.	0.639
ENSAPEP00000000658	ENSAPEP00000012737	ENSAPEP00000000658	ENSAPEP00000012737	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.	Growth differentiation factor 11.	0.416