(64 nodes) Negative regulation of secretion by cell network (Amphiprion percula)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSAPEP00000004083	Rhomboid 5 homolog 1b (Drosophila). (814 aa)
	ENSAPEP00000034739	Uncharacterized protein. (228 aa)
	ENSAPEP00000034840	Proteasome 26S subunit, non-ATPase 9. (212 aa)
	ENSAPEP00000007499	RAB11 family interacting protein 5a (class I). (1297 aa)
	RHBDF2	Rhomboid 5 homolog 2. (836 aa)
	ENSAPEP00000003008	Kruppel-like factor 7b. (309 aa)
	ENSAPEP00000034635	RAB guanine nucleotide exchange factor (GEF) 1, like. (507 aa)
	ENSAPEP00000034272	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (396 aa)
	ENSAPEP00000033294	Uncharacterized protein. (184 aa)
	ENSAPEP00000032544	Secretion regulating guanine nucleotide exchange factor. (407 aa)
	ENSAPEP00000031314	RAP1A, member of RAS oncogene family a. (185 aa)
	ENSAPEP00000031006	Si:ch73-71c20.5. (147 aa)
	ENSAPEP00000030718	Uncharacterized protein. (512 aa)
	ENSAPEP00000030371	annotation not available (260 aa)
	ENSAPEP00000029233	Apolipoprotein Ea. (260 aa)
	ENSAPEP00000021487	Fragile X mental retardation 1. (605 aa)
	ENSAPEP00000020186	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (593 aa)
	ENSAPEP00000020028	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	CCN3	Cellular communication network factor 3. (350 aa)
	ENSAPEP00000019733	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (331 aa)
	ENSAPEP00000018869	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (310 aa)
	ENSAPEP00000018825	Uncharacterized protein. (717 aa)
	ENSAPEP00000028834	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (307 aa)
	ENSAPEP00000028444	Synaptotagmin IV. (472 aa)
	ENSAPEP00000028343	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	ENSAPEP00000027171	Uncharacterized protein. (201 aa)
	ENSAPEP00000027103	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (411 aa)
	ENSAPEP00000026204	Potassium inwardly-rectifying channel, subfamily J, member 8. (419 aa)
	ENSAPEP00000026029	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
	ENSAPEP00000023447	Motilin_assoc domain-containing protein. (107 aa)
	ENSAPEP00000018643	Synaptotagmin XIb. (466 aa)
	ENSAPEP00000018281	3-hydroxy-3-methylglutaryl coenzyme A reductase. (890 aa)
	ENSAPEP00000018198	Uncharacterized protein. (161 aa)
	ENSAPEP00000018187	Urotensin 1. (148 aa)
	ENSAPEP00000017932	Kruppel like factor 7. (301 aa)
	FFAR4	Free fatty acid receptor 4. (345 aa)
	ENSAPEP00000016865	Uncharacterized protein. (1014 aa)
	ENSAPEP00000016854	Ubiquitin-like domain-containing protein. (413 aa)
	ENSAPEP00000016413	Tumor necrosis factor receptor superfamily, member 1a. (393 aa)
	ENSAPEP00000016392	PNKD metallo-beta-lactamase domain containing. (359 aa)
	IL12B-2	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (355 aa)
	ENSAPEP00000016136	Rhomboid 5 homolog 1a (Drosophila). (885 aa)
	ENSAPEP00000015322	Potassium inwardly-rectifying channel, subfamily J, member 11. (369 aa)
	ENSAPEP00000013848	Interleukin 11a. (199 aa)
	ENSAPEP00000013801	Uncharacterized protein. (185 aa)
	ENSAPEP00000023182	Thyrotropin-releasing hormone. (277 aa)
	ENSAPEP00000022807	RBR-type E3 ubiquitin transferase. (490 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (291 aa)
	ENSAPEP00000022243	Interleukin 1 receptor accessory protein-like 2. (671 aa)
	ENSAPEP00000011528	Midnolin. (544 aa)
	ENSAPEP00000011516	CACN subunit beta associated regulatory protein b. (683 aa)
	ENSAPEP00000010378	Neurofibromin 1b. (2763 aa)
	ENSAPEP00000009889	FIP-RBD domain-containing protein. (61 aa)
	VAMP3	Vesicle associated membrane protein 3. (112 aa)
	ENSAPEP00000008277	Interleukin 1 receptor accessory protein-like 1a. (681 aa)
	ENSAPEP00000000272	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	ENSAPEP00000000642	Chromogranin A. (372 aa)
	ENSAPEP00000001172	Vesicle-associated membrane protein 8 (endobrevin). (133 aa)
	ENSAPEP00000006980	RAB33B, member RAS oncogene family a. (244 aa)
	ENSAPEP00000006578	3-hydroxy-3-methylglutaryl coenzyme A reductase. (883 aa)
	ENSAPEP00000006287	NADH:ubiquinone oxidoreductase complex assembly factor 2. (175 aa)
	ENSAPEP00000005905	Si:dkey-163m14.2. (457 aa)
	ENSAPEP00000005716	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	ENSAPEP00000005261	Endothelin 2. (170 aa)

Your Current Organism:

Amphiprion percula

NCBI taxonomy Id: 161767
Other names: A. percula, Picasso clownfish, orange clownfish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPEP00000000272	ENSAPEP00000005905	ENSAPEP00000000272	ENSAPEP00000005905	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family.	Si:dkey-163m14.2.	0.535
ENSAPEP00000000272	ENSAPEP00000020028	ENSAPEP00000000272	ENSAPEP00000020028	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.553
ENSAPEP00000000272	ENSAPEP00000023447	ENSAPEP00000000272	ENSAPEP00000023447	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family.	Motilin_assoc domain-containing protein.	0.841
ENSAPEP00000000272	ENSAPEP00000027103	ENSAPEP00000000272	ENSAPEP00000027103	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.742
ENSAPEP00000000642	ENSAPEP00000023447	ENSAPEP00000000642	ENSAPEP00000023447	Chromogranin A.	Motilin_assoc domain-containing protein.	0.538
ENSAPEP00000001172	ENSAPEP00000018643	ENSAPEP00000001172	ENSAPEP00000018643	Vesicle-associated membrane protein 8 (endobrevin).	Synaptotagmin XIb.	0.744
ENSAPEP00000001172	ENSAPEP00000020186	ENSAPEP00000001172	ENSAPEP00000020186	Vesicle-associated membrane protein 8 (endobrevin).	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family.	0.869
ENSAPEP00000001172	ENSAPEP00000028444	ENSAPEP00000001172	ENSAPEP00000028444	Vesicle-associated membrane protein 8 (endobrevin).	Synaptotagmin IV.	0.744
ENSAPEP00000001172	VAMP3	ENSAPEP00000001172	ENSAPEP00000008768	Vesicle-associated membrane protein 8 (endobrevin).	Vesicle associated membrane protein 3.	0.814
ENSAPEP00000005716	ENSAPEP00000018187	ENSAPEP00000005716	ENSAPEP00000018187	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Urotensin 1.	0.787
ENSAPEP00000005905	ENSAPEP00000000272	ENSAPEP00000005905	ENSAPEP00000000272	Si:dkey-163m14.2.	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family.	0.535
ENSAPEP00000005905	ENSAPEP00000023182	ENSAPEP00000005905	ENSAPEP00000023182	Si:dkey-163m14.2.	Thyrotropin-releasing hormone.	0.582
ENSAPEP00000005905	ENSAPEP00000023447	ENSAPEP00000005905	ENSAPEP00000023447	Si:dkey-163m14.2.	Motilin_assoc domain-containing protein.	0.434
ENSAPEP00000005905	ENSAPEP00000027103	ENSAPEP00000005905	ENSAPEP00000027103	Si:dkey-163m14.2.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.540
ENSAPEP00000005905	ENSAPEP00000028343	ENSAPEP00000005905	ENSAPEP00000028343	Si:dkey-163m14.2.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.535
ENSAPEP00000005905	ENSAPEP00000034272	ENSAPEP00000005905	ENSAPEP00000034272	Si:dkey-163m14.2.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.535
ENSAPEP00000006578	ENSAPEP00000018281	ENSAPEP00000006578	ENSAPEP00000018281	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.897
ENSAPEP00000006980	ENSAPEP00000030718	ENSAPEP00000006980	ENSAPEP00000030718	RAB33B, member RAS oncogene family a.	Uncharacterized protein.	0.435
ENSAPEP00000006980	ENSAPEP00000031314	ENSAPEP00000006980	ENSAPEP00000031314	RAB33B, member RAS oncogene family a.	RAP1A, member of RAS oncogene family a.	0.411
ENSAPEP00000006980	ENSAPEP00000033294	ENSAPEP00000006980	ENSAPEP00000033294	RAB33B, member RAS oncogene family a.	Uncharacterized protein.	0.413