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AJT40375.1 AJT40375.1 AJT40376.1 AJT40376.1 AJT40377.1 AJT40377.1 AJT40378.1 AJT40378.1 aspA aspA AJT40430.1 AJT40430.1 AJT42752.1 AJT42752.1 AJT42753.1 AJT42753.1 AJT40451.1 AJT40451.1 AJT40456.1 AJT40456.1 AJT40458.1 AJT40458.1 AJT42759.1 AJT42759.1 AJT40463.1 AJT40463.1 AJT40465.1 AJT40465.1 AJT40523.1 AJT40523.1 AJT40524.1 AJT40524.1 AJT40525.1 AJT40525.1 AJT40527.1 AJT40527.1 AJT42776.1 AJT42776.1 AJT40532.1 AJT40532.1 mdh mdh AJT40655.1 AJT40655.1 AJT40656.1 AJT40656.1 AJT40657.1 AJT40657.1 AJT42827.1 AJT42827.1 lipA lipA lipB lipB AJT40756.1 AJT40756.1 AJT40757.1 AJT40757.1 acnA acnA AJT40897.1 AJT40897.1 AJT41096.1 AJT41096.1 AJT41105.1 AJT41105.1 AJT41197.1 AJT41197.1 AJT42926.1 AJT42926.1 AJT42933.1 AJT42933.1 mqo mqo AJT42940.1 AJT42940.1 AJT41291.1 AJT41291.1 AJT41292.1 AJT41292.1 kgd kgd AJT41566.1 AJT41566.1 AJT41855.1 AJT41855.1 AJT41887.1 AJT41887.1 AJT43057.1 AJT43057.1 ackA ackA AJT41901.1 AJT41901.1 acsA acsA AJT41969.1 AJT41969.1 AJT41972.1 AJT41972.1 AJT43079.1 AJT43079.1 AJT41973.1 AJT41973.1 AJT42085.1 AJT42085.1 AJT42086.1 AJT42086.1 AJT42087.1 AJT42087.1 AJT42107.1 AJT42107.1 pckG pckG AJT42184.1 AJT42184.1 AJT42185.1 AJT42185.1 AJT43133.1 AJT43133.1 AJT42574.1 AJT42574.1 AJT42575.1 AJT42575.1 AJT43210.1 AJT43210.1 sucC sucC sucD sucD AJT42709.1 AJT42709.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJT40375.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
AJT40376.1Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (587 aa)
AJT40377.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
AJT40378.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (115 aa)
aspAAspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (472 aa)
AJT40430.1Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (492 aa)
AJT42752.1Methylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
AJT42753.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (455 aa)
AJT40451.13-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
AJT40456.1Flavoprotein disulfide reductase; Catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
AJT40458.1acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (593 aa)
AJT42759.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (83 aa)
AJT40463.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (527 aa)
AJT40465.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
AJT40523.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
AJT40524.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (343 aa)
AJT40525.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
AJT40527.1methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (535 aa)
AJT42776.1acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (669 aa)
AJT40532.1Phosphonomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
AJT40655.1Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
AJT40656.1Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (305 aa)
AJT40657.12-methylcitrate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (506 aa)
AJT42827.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1132 aa)
lipARadical SAM protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (336 aa)
lipBOctanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (233 aa)
AJT40756.1Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (603 aa)
AJT40757.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
acnAAconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (956 aa)
AJT40897.1Lipoate--protein ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
AJT41096.1Lipoate--protein ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
AJT41105.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (457 aa)
AJT41197.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (582 aa)
AJT42926.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (917 aa)
AJT42933.13-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
mqoMalate:quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
AJT42940.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
AJT41291.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
AJT41292.1Biotin attachment protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (109 aa)
kgdAlpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (1274 aa)
AJT41566.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (427 aa)
AJT41855.14-aminobutyrate aminotransferase; Catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
AJT41887.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
AJT43057.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (384 aa)
AJT41901.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (687 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa)
AJT41969.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (586 aa)
AJT41972.13-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HIBADH-related family. (297 aa)
AJT43079.13-hydroxyisobutyryl-CoA hydrolase; Catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
AJT41973.1Methylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
AJT42085.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
AJT42086.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
AJT42087.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
AJT42107.1acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (653 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (607 aa)
AJT42184.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (416 aa)
AJT42185.1Citrate (Si)-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (393 aa)
AJT43133.1Nitrilase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
AJT42574.1Malate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family. (547 aa)
AJT42575.1Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
AJT43210.1FAD-linked oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (394 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (305 aa)
AJT42709.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (409 aa)
Your Current Organism:
Psychromicrobium lacuslunae
NCBI taxonomy Id: 1618207
Other names: Arthrobacter sp. IHBB 11108, JCM 31143, KACC 19070, MCC 2780, MTCC 12460, P. lacuslunae, strain IHBB 11108
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