STRINGSTRING
lipA lipA folD folD AJT40358.1 AJT40358.1 AJT42733.1 AJT42733.1 AJT40390.1 AJT40390.1 AJT40416.1 AJT40416.1 purE purE purK purK AJT40421.1 AJT40421.1 glmU glmU prs prs AJT42753.1 AJT42753.1 AJT42760.1 AJT42760.1 AJT40475.1 AJT40475.1 dnaG dnaG pyrH pyrH AJT40523.1 AJT40523.1 nusA nusA AJT40555.1 AJT40555.1 AJT40560.1 AJT40560.1 moaA moaA mtnP mtnP AJT40566.1 AJT40566.1 moaC moaC AJT40568.1 AJT40568.1 AJT40569.1 AJT40569.1 AJT42792.1 AJT42792.1 hisA hisA AJT40628.1 AJT40628.1 apt apt pyrG pyrG AJT42809.1 AJT42809.1 cmk cmk AJT40684.1 AJT40684.1 dinB dinB murD murD AJT40728.1 AJT40728.1 sigA sigA dxs dxs ribB ribB ribA ribA ribH ribH trpE trpE trpC trpC trpA trpA AJT40830.1 AJT40830.1 AJT40833.1 AJT40833.1 polA polA coaE coaE ctaB ctaB AJT40876.1 AJT40876.1 pdxS pdxS pdxT pdxT AJT42882.1 AJT42882.1 nusB nusB pyrB pyrB pyrC pyrC carA carA carB carB pyrF pyrF gmk gmk rpoZ rpoZ AJT40991.1 AJT40991.1 AJT40996.1 AJT40996.1 AJT41007.1 AJT41007.1 pyrD pyrD trpD trpD AJT41044.1 AJT41044.1 AJT41067.1 AJT41067.1 AJT41079.1 AJT41079.1 AJT42901.1 AJT42901.1 AJT41090.1 AJT41090.1 AJT41100.1 AJT41100.1 nadD nadD proA proA proB proB ndk ndk AJT41142.1 AJT41142.1 AJT41151.1 AJT41151.1 AJT41202.1 AJT41202.1 thiC thiC coaD coaD thiL thiL murA murA AJT41287.1 AJT41287.1 nadA nadA AJT42940.1 AJT42940.1 AJT41302.1 AJT41302.1 AJT41303.1 AJT41303.1 AJT41307.1 AJT41307.1 AJT42945.1 AJT42945.1 AJT41329.1 AJT41329.1 AJT41330.1 AJT41330.1 AJT41337.1 AJT41337.1 atpC atpC atpD atpD atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB atpB rho rho AJT41376.1 AJT41376.1 AJT41455.1 AJT41455.1 kynU kynU AJT41485.1 AJT41485.1 kbl kbl AJT41501.1 AJT41501.1 hemL hemL AJT41533.1 AJT41533.1 hemC hemC hemH hemH AJT41535.1 AJT41535.1 AJT41536.1 AJT41536.1 thiG thiG AJT41541.1 AJT41541.1 AJT41549.1 AJT41549.1 AJT41556.1 AJT41556.1 AJT41570.1 AJT41570.1 AJT41601.1 AJT41601.1 AJT41618.1 AJT41618.1 AJT41620.1 AJT41620.1 guaA guaA AJT41641.1 AJT41641.1 guaB guaB AJT41646.1 AJT41646.1 AJT41648.1 AJT41648.1 coaA coaA rpoA rpoA adk adk rpoC rpoC rpoB rpoB nusG nusG AJT41767.1 AJT41767.1 thyA thyA AJT41775.1 AJT41775.1 bioD bioD AJT41794.1 AJT41794.1 AJT43031.1 AJT43031.1 bioB bioB AJT41810.1 AJT41810.1 AJT41836.1 AJT41836.1 AJT41853.1 AJT41853.1 AJT41861.1 AJT41861.1 AJT41870.1 AJT41870.1 ackA ackA AJT41901.1 AJT41901.1 AJT41920.1 AJT41920.1 proC proC AJT41948.1 AJT41948.1 acsA acsA AJT41969.1 AJT41969.1 purC purC purF purF purM purM AJT42004.1 AJT42004.1 AJT43088.1 AJT43088.1 AJT42026.1 AJT42026.1 dcd dcd AJT42041.1 AJT42041.1 AJT43095.1 AJT43095.1 AJT43104.1 AJT43104.1 AJT42087.1 AJT42087.1 AJT42092.1 AJT42092.1 AJT42107.1 AJT42107.1 upp upp AJT42167.1 AJT42167.1 AJT42171.1 AJT42171.1 thiM thiM thiE thiE AJT43123.1 AJT43123.1 AJT42192.1 AJT42192.1 AJT42255.1 AJT42255.1 AJT42288.1 AJT42288.1 dnaE2 dnaE2 AJT42323.1 AJT42323.1 serS serS AJT42352.1 AJT42352.1 folE folE AJT42355.1 AJT42355.1 AJT42356.1 AJT42356.1 AJT42357.1 AJT42357.1 AJT42443.1 AJT42443.1 AJT42482.1 AJT42482.1 nadE nadE pyrE pyrE AJT42522.1 AJT42522.1 purA purA purL purL purQ purQ purS purS AJT42547.1 AJT42547.1 AJT42557.1 AJT42557.1 AJT42565.1 AJT42565.1 AJT42594.1 AJT42594.1 tmk tmk AJT42599.1 AJT42599.1 AJT43211.1 AJT43211.1 AJT42639.1 AJT42639.1 AJT42647.1 AJT42647.1 AJT42650.1 AJT42650.1 AJT42651.1 AJT42651.1 fdhD fdhD purN purN purH purH purU purU AJT42722.1 AJT42722.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
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experimentally determined
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gene neighborhood
gene fusions
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co-expression
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lipARadical SAM protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (336 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa)
AJT40358.1Sigma-70 family RNA polymerase sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. (296 aa)
AJT42733.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
AJT40390.1Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
AJT40416.1Mannose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
purEPhosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (191 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (391 aa)
AJT40421.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
glmUGlucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (488 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
AJT42753.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (455 aa)
AJT42760.1Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
AJT40475.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (632 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (246 aa)
AJT40523.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
nusATranscription elongation factor NusA; Participates in both transcription termination and antitermination. (323 aa)
AJT40555.1Riboflavin kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (321 aa)
AJT40560.1Molybdenum cofactor biosynthesis protein MoaD; Derived by automated computational analysis using gene prediction method: Protein Homology. (88 aa)
moaAMolybdenum cofactor biosynthesis protein MoeA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (344 aa)
mtnPHypothetical protein; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (280 aa)
AJT40566.1Hypothetical protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (411 aa)
moaCMolybdenum cofactor biosynthesis protein MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (165 aa)
AJT40568.1Molybdopterin biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
AJT40569.1Molybdenum cofactor biosynthesis protein MoaE; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
AJT42792.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CinA family. (155 aa)
hisAPhosphoribosyl isomerase; Catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
AJT40628.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (176 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (575 aa)
AJT42809.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (157 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
AJT40684.1RNA polymerase subunit sigma-24; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. (435 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (387 aa)
murDUDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (537 aa)
AJT40728.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1175 aa)
sigARNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (458 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (661 aa)
ribBHypothetical protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (213 aa)
ribAGTP cyclohydrolase; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (218 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (153 aa)
trpEAnthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (533 aa)
trpCIndole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (265 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (286 aa)
AJT40830.1UDP-glucose 6-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
AJT40833.1Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (885 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (396 aa)
ctaBProtoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (317 aa)
AJT40876.1Cytochrome oxidase assembly protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (302 aa)
pdxTGlutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (215 aa)
AJT42882.1GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (755 aa)
nusBAntitermination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (125 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (335 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (434 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (399 aa)
carBCarbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (1105 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (281 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (192 aa)
rpoZDNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (92 aa)
AJT40991.1Phosphopantothenoylcysteine decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
AJT40996.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
AJT41007.1Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (409 aa)
pyrDDiguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (358 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (350 aa)
AJT41044.1RNA polymerase sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (172 aa)
AJT41067.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (168 aa)
AJT41079.1Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
AJT42901.1Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
AJT41090.1RNA polymerase subunit sigma-24; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. (413 aa)
AJT41100.1Ribonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (325 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (189 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (436 aa)
proBGamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (375 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
AJT41142.1Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. (451 aa)
AJT41151.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
AJT41202.1Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (595 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (346 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (443 aa)
AJT41287.1Nicotinate-nucleotide pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. (294 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (430 aa)
AJT42940.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
AJT41302.1Ketosteroid isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa)
AJT41303.1MoaF protein precursor; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
AJT41307.1MoaF protein precursor; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
AJT42945.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
AJT41329.1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (437 aa)
AJT41330.1Nicotinamidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
AJT41337.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (107 aa)
atpCATP synthase F0F1 subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (96 aa)
atpDATP F0F1 synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (484 aa)
atpGATP synthase F0F1 subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (297 aa)
atpAATP synthase F0F1 subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (545 aa)
atpHATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (271 aa)
atpFATP synthase F0F1 subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (184 aa)
atpEATP synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa)
atpBATP synthase subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (266 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (690 aa)
AJT41376.1Inosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (492 aa)
AJT41455.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (431 aa)
AJT41485.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (171 aa)
kbl2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (398 aa)
AJT41501.1RNA polymerase sigma factor SigK; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (196 aa)
hemLGlutamate-1-semialdehyde aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
AJT41533.1Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (325 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (305 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (399 aa)
AJT41535.1Chlorite dismutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
AJT41536.1Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (471 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)
AJT41541.1Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (78 aa)
AJT41549.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
AJT41556.1RNA polymerase sigma factor SigE; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (201 aa)
AJT41570.1Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
AJT41601.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
AJT41618.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
AJT41620.1Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (535 aa)
AJT41641.1Inosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (505 aa)
AJT41646.1SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
AJT41648.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
coaAPantothenate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
rpoADNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (335 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (192 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1299 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1173 aa)
nusGTranscription termination factor NusG; Participates in transcription elongation, termination and antitermination. (256 aa)
AJT41767.1Fatty acid-binding protein; May play a role in the intracellular transport of hydrophobic ligands. (205 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (258 aa)
AJT41775.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (179 aa)
bioDHypothetical protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (226 aa)
AJT41794.18-amino-7-oxononanoate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
AJT43031.1Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (449 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (352 aa)
AJT41810.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
AJT41836.1Lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
AJT41853.1Ribose-phosphate pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
AJT41861.1Siroheme synthase CysG; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa)
AJT41870.1Cobalamin biosynthesis protein CbiX; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (384 aa)
AJT41901.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (687 aa)
AJT41920.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (125 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (278 aa)
AJT41948.13'-5' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa)
AJT41969.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (586 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (291 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (526 aa)
purMPhosphoribosylaminoimidazole synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
AJT42004.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
AJT43088.1Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (679 aa)
AJT42026.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
dcdDeoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
AJT42041.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (564 aa)
AJT43095.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
AJT43104.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (165 aa)
AJT42087.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
AJT42092.1Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
AJT42107.1acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (653 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa)
AJT42167.1Membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (233 aa)
AJT42171.13-demethylubiquinone-9 3-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (273 aa)
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (217 aa)
AJT43123.1Hydroxymethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
AJT42192.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
AJT42255.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (374 aa)
AJT42288.1Helicase DnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (460 aa)
dnaE2DNA polymerase III subunit alpha; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1223 aa)
AJT42323.1Glutamine amidotransferase; Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa)
AJT42352.1Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (183 aa)
folEGTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
AJT42355.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (310 aa)
AJT42356.1Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (124 aa)
AJT42357.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (167 aa)
AJT42443.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (190 aa)
AJT42482.1FAD-linked oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
nadENAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (273 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (190 aa)
AJT42522.1Phosphoribosylglycinamide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)
purLPhosphoribosylglycinamide synthetase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the tr [...] (759 aa)
purQPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (250 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (83 aa)
AJT42547.1DNA polymerase III subunit gamma/tau; Derived by automated computational analysis using gene prediction method: Protein Homology. (893 aa)
AJT42557.1Deaminase/reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
AJT42565.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
AJT42594.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (211 aa)
AJT42599.1CarD family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
AJT43211.1RNA polymerase sigma 70; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa)
AJT42639.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (163 aa)
AJT42647.1Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (375 aa)
AJT42650.1Molybdopterin-guanine dinucleotide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (98 aa)
AJT42651.1Molybdenum cofactor biosynthesis protein MoaA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (400 aa)
fdhDFormate dehydrogenase; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (286 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (185 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (541 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa)
AJT42722.1Methenyltetrahydrofolate cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
Your Current Organism:
Psychromicrobium lacuslunae
NCBI taxonomy Id: 1618207
Other names: Arthrobacter sp. IHBB 11108, JCM 31143, KACC 19070, MCC 2780, MTCC 12460, P. lacuslunae, strain IHBB 11108
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