STRINGSTRING
AJT41543.1 AJT41543.1 ruvC ruvC ruvA ruvA ruvB ruvB recO recO AJT41089.1 AJT41089.1 AJT41149.1 AJT41149.1 AJT41191.1 AJT41191.1 msrA msrA mutM mutM AJT41438.1 AJT41438.1 AJT41521.1 AJT41521.1 AJT41522.1 AJT41522.1 AJT41523.1 AJT41523.1 AJT41558.1 AJT41558.1 AJT42663.1 AJT42663.1 AJT42640.1 AJT42640.1 AJT42638.1 AJT42638.1 ung ung AJT42631.1 AJT42631.1 AJT42630.1 AJT42630.1 AJT42599.1 AJT42599.1 AJT42587.1 AJT42587.1 AJT42586.1 AJT42586.1 recR recR AJT42501.1 AJT42501.1 AJT42487.1 AJT42487.1 AJT42433.1 AJT42433.1 AJT42397.1 AJT42397.1 radA radA disA disA AJT43164.1 AJT43164.1 AJT42366.1 AJT42366.1 AJT42316.1 AJT42316.1 dnaE2 dnaE2 AJT42292.1 AJT42292.1 AJT42264.1 AJT42264.1 recF recF AJT42206.1 AJT42206.1 AJT42151.1 AJT42151.1 AJT43117.1 AJT43117.1 AJT42146.1 AJT42146.1 AJT42145.1 AJT42145.1 AJT42123.1 AJT42123.1 AJT42063.1 AJT42063.1 AJT42052.1 AJT42052.1 AJT43085.1 AJT43085.1 AJT43081.1 AJT43081.1 AJT41993.1 AJT41993.1 nth nth AJT41948.1 AJT41948.1 AJT41945.1 AJT41945.1 AJT41843.1 AJT41843.1 AJT41832.1 AJT41832.1 deaD deaD AJT41777.1 AJT41777.1 AJT41772.1 AJT41772.1 AJT41767.1 AJT41767.1 AJT42735.1 AJT42735.1 AJT42738.1 AJT42738.1 mfd mfd AJT40475.1 AJT40475.1 recA recA lexA lexA AJT40610.1 AJT40610.1 AJT40614.1 AJT40614.1 AJT40632.1 AJT40632.1 AJT40633.1 AJT40633.1 AJT42803.1 AJT42803.1 AJT40646.1 AJT40646.1 AJT40688.1 AJT40688.1 dinB dinB AJT40776.1 AJT40776.1 AJT40806.1 AJT40806.1 polA polA uvrB uvrB AJT40846.1 AJT40846.1 AJT40849.1 AJT40849.1 uvrA uvrA uvrC uvrC AJT42859.1 AJT42859.1 AJT42867.1 AJT42867.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJT41543.1DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DEAD box helicase family. (555 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (195 aa)
ruvAATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (217 aa)
ruvBATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (372 aa)
recODNA recombination protein RecO; Involved in DNA repair and RecF pathway recombination. (251 aa)
AJT41089.1Daunorubicin resistance protein DrrC; Derived by automated computational analysis using gene prediction method: Protein Homology. (792 aa)
AJT41149.1formamidopyrimidine-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPG family. (293 aa)
AJT41191.1NGG1p interacting factor 3 protein, NIF3; Derived by automated computational analysis using gene prediction method: Protein Homology. (298 aa)
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (174 aa)
mutMformamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (321 aa)
AJT41438.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
AJT41521.1DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1130 aa)
AJT41522.1DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1107 aa)
AJT41523.1Cysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
AJT41558.13-methyladenine DNA glycosylase; Constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
AJT42663.1Thioredoxin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (558 aa)
AJT42640.1Cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (168 aa)
AJT42638.1Cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (201 aa)
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (230 aa)
AJT42631.1FAD-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
AJT42630.1DNA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPG family. (297 aa)
AJT42599.1CarD family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
AJT42587.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (60 aa)
AJT42586.1Carbon starvation protein CstA; Derived by automated computational analysis using gene prediction method: Protein Homology. (752 aa)
recRRecombinase RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa)
AJT42501.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
AJT42487.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
AJT42433.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SOS response-associated peptidase family. (248 aa)
AJT42397.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (469 aa)
disADNA integrity scanning protein DisA; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. (358 aa)
AJT43164.1Fe-S cluster assembly protein HesB; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
AJT42366.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (109 aa)
AJT42316.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa)
dnaE2DNA polymerase III subunit alpha; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1223 aa)
AJT42292.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (501 aa)
AJT42264.1Thioredoxin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
recFRecombinase RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (400 aa)
AJT42206.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (634 aa)
AJT42151.1DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPG family. (276 aa)
AJT43117.1DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1600 aa)
AJT42146.1Heat-shock protein Hsp20; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the small heat shock protein (HSP20) family. (144 aa)
AJT42145.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
AJT42123.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
AJT42063.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
AJT42052.1Endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
AJT43085.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
AJT43081.1DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (539 aa)
AJT41993.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (270 aa)
AJT41948.13'-5' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
AJT41945.1Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (777 aa)
AJT41843.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0234 family. (162 aa)
AJT41832.13-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
deaDCold-shock protein; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (645 aa)
AJT41777.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
AJT41772.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
AJT41767.1Fatty acid-binding protein; May play a role in the intracellular transport of hydrophobic ligands. (205 aa)
AJT42735.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
AJT42738.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1204 aa)
AJT40475.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (351 aa)
lexALexA family transcriptional regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (235 aa)
AJT40610.1DNA mismatch repair protein MutT; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family. (144 aa)
AJT40614.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
AJT40632.1Cysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
AJT40633.13-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa)
AJT42803.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA glycosylase MPG family. (205 aa)
AJT40646.1DNA recombination protein RecN; May be involved in recombinational repair of damaged DNA. (565 aa)
AJT40688.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (387 aa)
AJT40776.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
AJT40806.1Cytochrome P450; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (885 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (693 aa)
AJT40846.1DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (845 aa)
AJT40849.1Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (969 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (660 aa)
AJT42859.1Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (209 aa)
AJT42867.1Peroxiredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
Your Current Organism:
Psychromicrobium lacuslunae
NCBI taxonomy Id: 1618207
Other names: Arthrobacter sp. IHBB 11108, JCM 31143, KACC 19070, MCC 2780, MTCC 12460, P. lacuslunae, strain IHBB 11108
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