(30 nodes) Glyoxylate and dicarboxylate metabolism network (Psychromicrobium lacuslunae)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	AJT40458.1	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (593 aa)
	AJT40463.1	methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (527 aa)
	AJT42776.1	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (669 aa)
	mdh	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
	AJT40692.1	methylmalonyl-CoA epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (121 aa)
	gcvH	Glycine cleavage system potein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
	AJT40736.1	Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (446 aa)
	AJT40744.1	Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
	AJT40757.1	Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
	acnA	Aconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (956 aa)
	AJT42858.1	Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
	AJT42872.1	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa)
	AJT41566.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (427 aa)
	gcvT	Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (384 aa)
	gcvH-2	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa)
	glyA	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa)
	AJT41744.1	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
	AJT41849.1	Catalase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the catalase family. (508 aa)
	acsA	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa)
	AJT41969.1	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (586 aa)
	AJT42107.1	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (653 aa)
	AJT42184.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (416 aa)
	AJT42185.1	Citrate (Si)-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (393 aa)
	AJT42332.1	Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (374 aa)
	AJT42451.1	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
	AJT42574.1	Malate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family. (547 aa)
	AJT42575.1	Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
	AJT43210.1	FAD-linked oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
	purU	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa)
	glyA-2	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)

Your Current Organism:

Psychromicrobium lacuslunae

NCBI taxonomy Id: 1618207
Other names: Arthrobacter sp. IHBB 11108, JCM 31143, KACC 19070, MCC 2780, MTCC 12460, P. lacuslunae, strain IHBB 11108

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJT40458.1	AJT40463.1	UM93_00840	UM93_00880	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AJT40458.1	AJT40692.1	UM93_00840	UM93_02635	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	methylmalonyl-CoA epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
AJT40458.1	AJT41566.1	UM93_00840	UM93_08680	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.	0.833
AJT40458.1	AJT41744.1	UM93_00840	UM93_09865	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family.	0.927
AJT40458.1	AJT41969.1	UM93_00840	UM93_11440	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.918
AJT40458.1	AJT42107.1	UM93_00840	UM93_12405	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.914
AJT40458.1	AJT42184.1	UM93_00840	UM93_12965	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.	0.833
AJT40458.1	AJT42185.1	UM93_00840	UM93_12970	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Citrate (Si)-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.	0.841
AJT40458.1	AJT42451.1	UM93_00840	UM93_14825	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family.	0.927
AJT40458.1	AJT42574.1	UM93_00840	UM93_15775	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Malate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family.	0.917
AJT40458.1	AJT42776.1	UM93_00840	UM93_01380	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.911
AJT40458.1	AJT42872.1	UM93_00840	UM93_04235	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family.	0.927
AJT40458.1	acsA	UM93_00840	UM93_11310	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.914
AJT40463.1	AJT40458.1	UM93_00880	UM93_00840	methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AJT40463.1	AJT40692.1	UM93_00880	UM93_02635	methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	methylmalonyl-CoA epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
AJT40463.1	AJT41969.1	UM93_00880	UM93_11440	methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.917
AJT40463.1	AJT42107.1	UM93_00880	UM93_12405	methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.915
AJT40463.1	AJT42776.1	UM93_00880	UM93_01380	methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AJT40463.1	acsA	UM93_00880	UM93_11310	methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.915
AJT40463.1	mdh	UM93_00880	UM93_01555	methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.	0.533