STRINGSTRING
ARJ03829.1 ARJ03829.1 ARJ07098.1 ARJ07098.1 ARJ03982.1 ARJ03982.1 ARJ04054.1 ARJ04054.1 ARJ04180.1 ARJ04180.1 ARJ04206.1 ARJ04206.1 proC proC ARJ04438.1 ARJ04438.1 ARJ04445.1 ARJ04445.1 sucC sucC sucD sucD ARJ04675.1 ARJ04675.1 pckG pckG leuA leuA ARJ05002.1 ARJ05002.1 ARJ05030.1 ARJ05030.1 ARJ05087.1 ARJ05087.1 proB proB proA proA ARJ05129.1 ARJ05129.1 ARJ05223.1 ARJ05223.1 ARJ05234.1 ARJ05234.1 ARJ05260.1 ARJ05260.1 gltD gltD ARJ05382.1 ARJ05382.1 acnA acnA ARJ05473.1 ARJ05473.1 ARJ05474.1 ARJ05474.1 ARJ05478.1 ARJ05478.1 ARJ05500.1 ARJ05500.1 ARJ05512.1 ARJ05512.1 leuA-2 leuA-2 ARJ05624.1 ARJ05624.1 ARJ05652.1 ARJ05652.1 ARJ05653.1 ARJ05653.1 ARJ05706.1 ARJ05706.1 gcvP gcvP gcvH gcvH ARJ07331.1 ARJ07331.1 aspA-2 aspA-2 ARJ05759.1 ARJ05759.1 ARJ05760.1 ARJ05760.1 leuD leuD leuC leuC ARJ05936.1 ARJ05936.1 leuB leuB ilvC ilvC ARJ05949.1 ARJ05949.1 ARJ05950.1 ARJ05950.1 ilvD ilvD ARJ06024.1 ARJ06024.1 ARJ06027.1 ARJ06027.1 ARJ06044.1 ARJ06044.1 ARJ06045.1 ARJ06045.1 ARJ06046.1 ARJ06046.1 ARJ06047.1 ARJ06047.1 mqo mqo mdh mdh ARJ06377.1 ARJ06377.1 ppc ppc ARJ06495.1 ARJ06495.1 ARJ06668.1 ARJ06668.1 ARJ06718.1 ARJ06718.1 ARJ06719.1 ARJ06719.1 ARJ06748.1 ARJ06748.1 ARJ06749.1 ARJ06749.1 ARJ07463.1 ARJ07463.1 ARJ06750.1 ARJ06750.1 ARJ06830.1 ARJ06830.1 fumC fumC ARJ07057.1 ARJ07057.1 ARJ07499.1 ARJ07499.1 ARJ07058.1 ARJ07058.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARJ03829.1Lactate 2-monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
ARJ07098.11-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (1181 aa)
ARJ03982.1Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (550 aa)
ARJ04054.11-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (1169 aa)
ARJ04180.1Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (557 aa)
ARJ04206.1NAD-dependent succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (502 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (277 aa)
ARJ04438.1NAD-dependent succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
ARJ04445.1Alpha-hydroxy-acid oxidizing enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
sucCsuccinate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa)
sucDsuccinate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
ARJ04675.1Isocitrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)
pckGvaline--tRNA ligase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (611 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (580 aa)
ARJ05002.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (577 aa)
ARJ05030.1Alpha-hydroxy-acid oxidizing enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (424 aa)
ARJ05087.14-aminobutyrate--2-oxoglutarate transaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (454 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (277 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (426 aa)
ARJ05129.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1137 aa)
ARJ05223.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa)
ARJ05234.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
ARJ05260.1Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)
ARJ05382.1Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (1526 aa)
acnAAconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (947 aa)
ARJ05473.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
ARJ05474.12-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (489 aa)
ARJ05478.1Type I glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
ARJ05500.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (445 aa)
ARJ05512.1Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (908 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (588 aa)
ARJ05624.12-oxoglutarate dehydrogenase E1 component; Derived by automated computational analysis using gene prediction method: Protein Homology. (1261 aa)
ARJ05652.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (549 aa)
ARJ05653.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
ARJ05706.1Citrate (Si)-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (434 aa)
gcvPGlycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
ARJ07331.1Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
aspA-2Aspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (470 aa)
ARJ05759.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (498 aa)
ARJ05760.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (724 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (482 aa)
ARJ05936.1Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (354 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (341 aa)
ARJ05949.1Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
ARJ05950.1Acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (604 aa)
ilvDDihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (564 aa)
ARJ06024.1NAD(P)H-quinone dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
ARJ06027.1Pyruvate oxidase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (577 aa)
ARJ06044.1Succinate dehydrogenase, cytochrome b556 subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
ARJ06045.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
ARJ06046.1Succinate dehydrogenase flavoprotein subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (603 aa)
ARJ06047.1Succinate dehydrogenase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (255 aa)
mqoMalate:quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (501 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (348 aa)
ARJ06377.1citryl-CoA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (892 aa)
ARJ06495.1Acetolactate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-acetolactate decarboxylase family. (245 aa)
ARJ06668.1Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (616 aa)
ARJ06718.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (731 aa)
ARJ06719.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
ARJ06748.14-aminobutyrate--2-oxoglutarate transaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (464 aa)
ARJ06749.1Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (433 aa)
ARJ07463.1NAD-dependent succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (493 aa)
ARJ06750.1Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
ARJ06830.13-isopropylmalate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (366 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (502 aa)
ARJ07057.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
ARJ07499.1Alpha-ketoacid dehydrogenase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
ARJ07058.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
Your Current Organism:
Cnuibacter physcomitrellae
NCBI taxonomy Id: 1619308
Other names: C. physcomitrellae, CGMCC 1.15041, Cnuibacter physcomitrellae Zhou et al. 2016, DSM 29843, Microbacteriaceae bacterium XA, strain XA
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