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pyrE pyrE yrfG yrfG cpdA cpdA pyrI pyrI pyrB pyrB yjjG yjjG deoD deoD carA carA carB carB folA folA guaC guaC hpt hpt gpt gpt ppnP ppnP apt apt adk adk gsk gsk ushA ushA purK purK purE purE pyrD pyrD tmk tmk purB purB CUU23760.1 CUU23760.1 add add CUU24022.1 CUU24022.1 pyrF pyrF tdk tdk purT purT amn amn udk udk cdd cdd CUU24743.1 CUU24743.1 purF purF purC purC uraA uraA upp upp purM purM purN purN guaA guaA guaB guaB purL purL ygdH ygdH thyA thyA cpdB cpdB purA purA purH purH purD purD ubiB1 ubiB1 udp udp cyaA cyaA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
yrfGGMP/IMP nucleotidase YrfG. (241 aa)
cpdA3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (275 aa)
pyrIAspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (154 aa)
pyrBAspartate carbamoyltransferase, catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa)
yjjGPyrimidine 5'-nucleotidase YjjG. (226 aa)
deoDPurine nucleoside phosphorylase. (239 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (396 aa)
carBCarbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1074 aa)
folADihydrofolate reductase type I; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (182 aa)
guaCGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (346 aa)
hptHypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa)
gptGuanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa)
ppnPUPF0345 protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (94 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
gskInosine-guanosine kinase. (433 aa)
ushAProtein UshA; Belongs to the 5'-nucleotidase family. (582 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (356 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (211 aa)
purBAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa)
CUU23760.1Glutamine amidotransferase. (235 aa)
addAdenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (335 aa)
CUU24022.1Metallophosphoesterase. (241 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (239 aa)
tdkThymidine kinase. (206 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (392 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (485 aa)
udkUridine kinase. (213 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (295 aa)
CUU24743.1UPF0207 protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (199 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (237 aa)
uraAUracil permease. (427 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)
purMPhosphoribosylaminoimidazole synthetase. (346 aa)
purNPhosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (526 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1296 aa)
ygdHLOG family protein YgdH. (454 aa)
thyAThymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
cpdB2',3'-cyclic-nucleotide 2'-phosphodiesterase; Belongs to the 5'-nucleotidase family. (650 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase. (529 aa)
purDPhosphoribosylamine-glycine ligase; Belongs to the GARS family. (426 aa)
ubiB1FMN reductase. (233 aa)
udpUridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (254 aa)
cyaAAdenylate cyclase; Belongs to the adenylyl cyclase class-1 family. (849 aa)
Your Current Organism:
Erwinia gerundensis
NCBI taxonomy Id: 1619313
Other names: CCOS 903, CCOS:903, E. gerundensis, Erwinia gerundensis Rezzonico et al. 2016, Erwinia sp. 08-046A, Erwinia sp. 08-069A, Erwinia sp. 08-085C, Erwinia sp. 6-RJ-7B, Erwinia sp. EM406, Erwinia sp. EM436, Erwinia sp. EM477, Erwinia sp. EM486, Erwinia sp. EM573, Erwinia sp. EM595, Erwinia sp. EM603, Erwinia sp. KAZ28, LMG 28990, LMG:28990, Pantoea sp. EM486, Pantoea sp. EM595, Pantoea sp. P10QLC, Pantoea sp. P8SAA, strain EM595
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