STRINGSTRING
mdoG mdoG CUU22288.1 CUU22288.1 kdtX kdtX kdtA kdtA rfaG rfaG rfaQ rfaQ CUU22310.1 CUU22310.1 CUU22311.1 CUU22311.1 CUU22313.1 CUU22313.1 rfaC rfaC rfaF rfaF CUU22319.1 CUU22319.1 pfkA1 pfkA1 glpX glpX glpK glpK iolB iolB iolD iolD iolG iolG iolE iolE glgB glgB glgX1 glgX1 glgC glgC glgA glgA glpE glpE slyX slyX lpxP lpxP yrbI yrbI rfaE rfaE mak1 mak1 mdoB mdoB mak2 mak2 nagC nagC galK galK kdsB kdsB mdoC mdoC mdoH mdoH htrB htrB icdA icdA treA treA CUU23786.1 CUU23786.1 kdsA kdsA araB araB CUU24009.1 CUU24009.1 pfkA2 pfkA2 rhaB rhaB yciM yciM lapA lapA CUU24223.1 CUU24223.1 CUU24224.1 CUU24224.1 msbB msbB gldA gldA otsA otsA otsB otsB eptA eptA yedP yedP phnN phnN maa maa cscA cscA CUU24554.1 CUU24554.1 CUU24555.1 CUU24555.1 gtrB gtrB CUU24600.1 CUU24600.1 CUU24601.1 CUU24601.1 gnd gnd CUU24603.1 CUU24603.1 CUU24604.1 CUU24604.1 CUU24607.1 CUU24607.1 CUU24615.1 CUU24615.1 wceN wceN wzc wzc ydfI ydfI fruK fruK yeiU yeiU spr spr CUU24693.1 CUU24693.1 mdoD mdoD glk glk CUU24822.1 CUU24822.1 suhB suhB treC treC ygjR ygjR uxaB uxaB cysQ cysQ dhaK dhaK rfbX rfbX yjbH yjbH gfcB gfcB treZ treZ glgX2 glgX2 wecG wecG wzy wzy wecF wecF wzx wzx wecE wecE rmlA2 rmlA2 wecC wecC wecB wecB wzzE wzzE wecA wecA kdgK1 kdgK1 bcsC bcsC bcsB bcsB bcsA bcsA CUU25586.1 CUU25586.1 CUU25587.1 CUU25587.1 bcsG bcsG celY celY CUU25591.1 CUU25591.1 CUU25592.1 CUU25592.1 acsAB acsAB eptB eptB mtlD mtlD yiaH yiaH xylB xylB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mdoGGlucans biosynthesis protein G precursor; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (520 aa)
CUU22288.1Colanic acid exporter. (213 aa)
kdtXLipopolysaccharide core biosynthesis glycosyl transferase. (256 aa)
kdtA3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (424 aa)
rfaGPutative glycosyltransferase. (378 aa)
rfaQPutative lipopolysaccharide core biosynthesis protein. (358 aa)
CUU22310.1Glycosyltransferase. (364 aa)
CUU22311.1Glycosyltransferase. (372 aa)
CUU22313.1Lipid A core-surface polymer ligase WaaL. (414 aa)
rfaCLipopolysaccharide heptosyltransferase-1. (322 aa)
rfaFADP-heptose-lps heptosyltransferase II. (338 aa)
CUU22319.1Glycosyl transferase family 1. (409 aa)
pfkA16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa)
glpXFructose-1,6-bisphosphatase class II glpX. (336 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (482 aa)
iolBMyo-inositol catabolism protein IolB. (271 aa)
iolDMalonic semialdehyde oxidative decarboxylase; Belongs to the TPP enzyme family. (646 aa)
iolGMyo-inositol 2-dehydrogenase; Involved in the oxidation of myo-inositol (MI) to 2-keto-myo- inositol (2KMI or 2-inosose). (337 aa)
iolEInosose dehydratase; Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)- trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol). Belongs to the IolE/MocC family. (298 aa)
glgB1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (729 aa)
glgX1Glycogen operon protein GlgX; Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin. (661 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (429 aa)
glgAGlycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (477 aa)
glpEHypothetical protein; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. (106 aa)
slyXHypothetical protein; Belongs to the SlyX family. (72 aa)
lpxPProtein Ddg; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (323 aa)
yrbIPutative 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (188 aa)
rfaEADP-heptose synthase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (475 aa)
mak1Fructokinase. (310 aa)
mdoBPhosphoglycerol transferase I. (752 aa)
mak2Fructokinase. (303 aa)
nagCN-acetylglucosamine repressor. (406 aa)
galKGalactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (382 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa)
mdoCGlucans biosynthesis protein C; Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane. (385 aa)
mdoHGlucans biosynthesis glucosyltransferase H; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (856 aa)
htrBLipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa)
icdAIsocitrate dehydrogenase. (416 aa)
treATrehalase, periplasmic; Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system; Belongs to the glycosyl hydrolase 37 family. (556 aa)
CUU23786.1Dehydrogenase. (337 aa)
kdsA2-dehydro-3-deoxyphosphooctulonate aldolase; Belongs to the KdsA family. (284 aa)
araBL-ribulokinase. (561 aa)
CUU24009.1Putative dehydrogenase. (346 aa)
pfkA2Putative 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (326 aa)
rhaBRhamnulokinase; Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1- hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. Belongs to the rhamnulokinase family. (490 aa)
yciMPutative protein YciM; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. (389 aa)
lapAHypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. (103 aa)
CUU24223.1Putative 37,6 kDa protein in cld 5'region. (122 aa)
CUU24224.1Putative 37,6 kDa protein in cld 5'region. (233 aa)
msbBLipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa)
gldAGlycerol dehydrogenase. (365 aa)
otsATrehalose-6-phosphate synthase; Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D- glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose- 6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor; Belongs to the glycosyltransferase 20 family. (478 aa)
otsBTrehalose-6-phosphate phosphatase; Removes the phosphate from trehalose 6-phosphate to produce free trehalose. (261 aa)
eptAPhosphoethanolamine transferase EptA. (546 aa)
yedPPutative mannosyl-3-phosphoglycerate phosphatase. (262 aa)
phnNRibose 1,5-bisphosphate phosphokinase PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (180 aa)
maaMaltose O-acetyltransferase. (185 aa)
cscASucrose-6-phosphate hydrolase; Enables the bacterium to metabolize sucrose as a sole carbon source; Belongs to the glycosyl hydrolase 32 family. (477 aa)
CUU24554.1Glycosyl transferase. (275 aa)
CUU24555.1Myo-inositol 2-dehydrogenase. (373 aa)
gtrBBactoprenol glucosyl transferase. (308 aa)
CUU24600.1Glycosyl transferase family protein. (314 aa)
CUU24601.1Acetylase. (855 aa)
gnd6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (478 aa)
CUU24603.1Hypothetical protein. (371 aa)
CUU24604.1Mannosyltransferase. (387 aa)
CUU24607.1Glycosyl transferase family 1. (1242 aa)
CUU24615.1Putative membrane protein. (430 aa)
wceNExtracellular polysaccharide biosynthesis protein wceN. (344 aa)
wzcPutative tyrosine-protein kinase. (691 aa)
ydfIPutative oxidoreductase YdfI; Belongs to the mannitol dehydrogenase family. (487 aa)
fruKFructose-1-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. (312 aa)
yeiUInner membrane protein YeiU; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (235 aa)
sprPutative endopeptidase Spr. (191 aa)
CUU24693.1Acyltransferase 3. (361 aa)
mdoDGlucans biosynthesis protein D; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (552 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (321 aa)
CUU24822.1Hypothetical protein. (622 aa)
suhBInositol-1-monophosphatase. (267 aa)
treCTrehalose-6-phosphate hydrolase. (549 aa)
ygjRPutative oxidoreductase YgjR. (332 aa)
uxaBAltronate oxidoreductase. (479 aa)
cysQPAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (248 aa)
dhaKDihydroxyacetone kinase. (545 aa)
rfbXPutative PST family transporter. (418 aa)
yjbHPutative lipoprotein YjbH. (696 aa)
gfcBPutative lipoprotein GfcB. (215 aa)
treZMalto-oligosyltrehalose trehalohydrolase. (595 aa)
glgX2Glycogen operon GlgX-like protein; Belongs to the glycosyl hydrolase 13 family. (691 aa)
wecGPutative UDP-N-acetyl-D-mannosaminuronic acid transferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis. (246 aa)
wzyPutative enterobacterial common antigen polymerase wzy; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units; Belongs to the WzyE family. (449 aa)
wecF4-alpha-L-fucosyltransferase. (356 aa)
wzxPutative lipopolysaccharide biosynthesis protein wzx; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. (416 aa)
wecETDP-4-keto-6-deoxy-D-glucose transaminase; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate; Belongs to the DegT/DnrJ/EryC1 family. (376 aa)
rmlA2Glucose-1-phosphate thymidylyltransferase 2; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (293 aa)
wecCUDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
wecBUDP-N-acetylglucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. (373 aa)
wzzELipopolysaccharide biosynthesis protein WzzE; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. (349 aa)
wecAPutative undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (360 aa)
kdgK1Ketodeoxygluconokinase. (310 aa)
bcsCCellulose synthase operon protein C. (1157 aa)
bcsBCyclic di-GMP-binding protein; Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); Belongs to the AcsB/BcsB family. (753 aa)
bcsACellulose synthase catalytic subunit [UDP-forming]; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose. (872 aa)
CUU25586.1Hypothetical protein. (65 aa)
CUU25587.1Cellulose biosynthesis protein. (512 aa)
bcsGCellulose biosynthesis protein BcsG. (550 aa)
celYMinor endoglucanase Y. (323 aa)
CUU25591.1Cellulose synthase. (147 aa)
CUU25592.1Putative N-acetylglucosaminyl transferase. (1268 aa)
acsABCellulose synthase 1; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose. (700 aa)
eptBPhosphoethanolamine transferase EptB. (562 aa)
mtlDMannitol-1-phosphate 5-dehydrogenase. (382 aa)
yiaHInner membrane protein YiaH; Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units. (331 aa)
xylBXylulokinase. (488 aa)
Your Current Organism:
Erwinia gerundensis
NCBI taxonomy Id: 1619313
Other names: CCOS 903, CCOS:903, E. gerundensis, Erwinia gerundensis Rezzonico et al. 2016, Erwinia sp. 08-046A, Erwinia sp. 08-069A, Erwinia sp. 08-085C, Erwinia sp. 6-RJ-7B, Erwinia sp. EM406, Erwinia sp. EM436, Erwinia sp. EM477, Erwinia sp. EM486, Erwinia sp. EM573, Erwinia sp. EM595, Erwinia sp. EM603, Erwinia sp. KAZ28, LMG 28990, LMG:28990, Pantoea sp. EM486, Pantoea sp. EM595, Pantoea sp. P10QLC, Pantoea sp. P8SAA, strain EM595
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