STRINGSTRING
OMJ30456.1 OMJ30456.1 surE surE OMJ30619.1 OMJ30619.1 pyrD pyrD dcd dcd OMJ33930.1 OMJ33930.1 OMJ33971.1 OMJ33971.1 carB carB carA carA pyrH pyrH nrdR nrdR OMJ33341.1 OMJ33341.1 OMJ33389.1 OMJ33389.1 pyrB pyrB OMJ33210.1 OMJ33210.1 pyrF pyrF tdk tdk OMJ32571.1 OMJ32571.1 OMJ32592.1 OMJ32592.1 OMJ32493.1 OMJ32493.1 dut dut OMJ32405.1 OMJ32405.1 OMJ32272.1 OMJ32272.1 tgt tgt BSZ14_09330 BSZ14_09330 ndk ndk OMJ32091.1 OMJ32091.1 pyrE pyrE OMJ32124.1 OMJ32124.1 OMJ31970.1 OMJ31970.1 OMJ31734.1 OMJ31734.1 OMJ31738.1 OMJ31738.1 pyrG pyrG groS groS OMJ31426.1 OMJ31426.1 tmk tmk OMJ31164.1 OMJ31164.1 OMJ31140.1 OMJ31140.1 OMJ31165.1 OMJ31165.1 OMJ31113.1 OMJ31113.1 OMJ30941.1 OMJ30941.1 OMJ30828.1 OMJ30828.1 cmk cmk thyA thyA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OMJ30456.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (73 aa)
surE5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (254 aa)
OMJ30619.1Dihydroorotase; Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
pyrDDihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (342 aa)
dcddCTP deaminase; Catalyzes the deamination of dCTP to dUTP. (184 aa)
OMJ33930.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (498 aa)
OMJ33971.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1110 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (392 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
nrdRTranscriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (155 aa)
OMJ33341.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
OMJ33389.1Nuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (327 aa)
OMJ33210.1Dihydroorotase; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (224 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
OMJ32571.1HNH endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
OMJ32592.1Rossman fold protein, TIGR00730 family; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LOG family. (193 aa)
OMJ32493.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (149 aa)
OMJ32405.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
OMJ32272.1Rossman fold protein, TIGR00730 family; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LOG family. (295 aa)
tgttRNA guanosine(34) transglycosylase Tgt; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose t [...] (376 aa)
BSZ14_09330Multidrug transporter AcrB; Frameshifted; incomplete; partial in the middle of a contig; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
OMJ32091.1SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methyltransferase superfamily. (289 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (194 aa)
OMJ32124.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
OMJ31970.1Malonic semialdehyde reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
OMJ31734.1Endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
OMJ31738.1Deoxycytidylate deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (554 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (549 aa)
groSCo-chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (95 aa)
OMJ31426.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (193 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (223 aa)
OMJ31164.1Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (640 aa)
OMJ31140.1Ribonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (351 aa)
OMJ31165.1HNH endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (94 aa)
OMJ31113.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
OMJ30941.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
OMJ30828.1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (154 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
Your Current Organism:
Sphingomonas sp. Sph1
NCBI taxonomy Id: 1628084
Other names: S. sp. Sph1(2015), Sphingomonas sp. Sph1(2015)
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.