27 items (Thermococcus cleftensis) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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protein homology

Your Input:
	CL1_0205	4-aminobutyrate aminotransferase 1; COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (447 aa)
	CL1_0496	Putative aminotransferase 3; COG0436. (544 aa)
	CL1_0684	Pyrazinamidase/nicotinamidase-like protein; COG1335. (181 aa)
	CL1_0744	Putative carbon-nitrogen hydrolase; COG0388. (264 aa)
	CL1_0797	Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (277 aa)
	nadA	Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (302 aa)
	CL1_0800	L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (465 aa)
	CL1_0801	Hypothetical protein. (463 aa)
	CL1_0802	Hypothetical protein; COG0346. (410 aa)
	nadE	Putative NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (254 aa)
	mfnA	Tyrosine decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (384 aa)
	nadK	NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (278 aa)
	CL1_1122	4-aminobutyrate aminotransferase 2; COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa)
	CL1_1196	GHMP kinase 2; COG1829. (300 aa)
	CL1_1259	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (302 aa)
	pyrI	Aspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (151 aa)
	CL1_1333	L-asparaginase; COG1446. (306 aa)
	CL1_1355	Nicotinate phosphoribosyltransferase; COG1488. (390 aa)
	CL1_1361	Hypothetical protein; COG1701. (260 aa)
	CL1_1397	Putative aminotransferase 4; COG1167. (418 aa)
	CL1_1539	Archaeal nicotinamide-nucleotide adenylyltransferase; COG1056. (187 aa)
	CL1_1658	Putative maleate cis-trans isomerase; COG3473. (237 aa)
	cobB	NAD-dependent deacetylase; COG0846; Belongs to the sirtuin family. Class III subfamily. (251 aa)
	CL1_1883	Putative aspartate racemase 1; COG1794. (226 aa)
	CL1_1885	Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; COG0452. (405 aa)
	panB	3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (285 aa)
	CL1_2035	Putative aspartate racemase 2; COG1794. (235 aa)

Your Current Organism:

Thermococcus cleftensis

NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CL1_0205	CL1_0744	CL1_0205	CL1_0744	4-aminobutyrate aminotransferase 1; COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Putative carbon-nitrogen hydrolase; COG0388.	0.951
CL1_0205	CL1_1122	CL1_0205	CL1_1122	4-aminobutyrate aminotransferase 1; COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	4-aminobutyrate aminotransferase 2; COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.909
CL1_0205	CL1_1361	CL1_0205	CL1_1361	4-aminobutyrate aminotransferase 1; COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Hypothetical protein; COG1701.	0.900
CL1_0205	CL1_1397	CL1_0205	CL1_1397	4-aminobutyrate aminotransferase 1; COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Putative aminotransferase 4; COG1167.	0.438
CL1_0205	mfnA	CL1_0205	CL1_0978	4-aminobutyrate aminotransferase 1; COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Tyrosine decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily.	0.940
CL1_0496	CL1_0800	CL1_0496	CL1_0800	Putative aminotransferase 3; COG0436.	L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.	0.919
CL1_0496	CL1_1333	CL1_0496	CL1_1333	Putative aminotransferase 3; COG0436.	L-asparaginase; COG1446.	0.902
CL1_0496	CL1_1658	CL1_0496	CL1_1658	Putative aminotransferase 3; COG0436.	Putative maleate cis-trans isomerase; COG3473.	0.842
CL1_0496	CL1_1883	CL1_0496	CL1_1883	Putative aminotransferase 3; COG0436.	Putative aspartate racemase 1; COG1794.	0.913
CL1_0496	CL1_2035	CL1_0496	CL1_2035	Putative aminotransferase 3; COG0436.	Putative aspartate racemase 2; COG1794.	0.901
CL1_0496	mfnA	CL1_0496	CL1_0978	Putative aminotransferase 3; COG0436.	Tyrosine decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily.	0.864
CL1_0496	pyrI	CL1_0496	CL1_1293	Putative aminotransferase 3; COG0436.	Aspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase.	0.900
CL1_0684	CL1_1355	CL1_0684	CL1_1355	Pyrazinamidase/nicotinamidase-like protein; COG1335.	Nicotinate phosphoribosyltransferase; COG1488.	0.970
CL1_0684	cobB	CL1_0684	CL1_1871	Pyrazinamidase/nicotinamidase-like protein; COG1335.	NAD-dependent deacetylase; COG0846; Belongs to the sirtuin family. Class III subfamily.	0.928
CL1_0744	CL1_0205	CL1_0744	CL1_0205	Putative carbon-nitrogen hydrolase; COG0388.	4-aminobutyrate aminotransferase 1; COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.951
CL1_0744	CL1_0797	CL1_0744	CL1_0797	Putative carbon-nitrogen hydrolase; COG0388.	Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.488
CL1_0744	CL1_0800	CL1_0744	CL1_0800	Putative carbon-nitrogen hydrolase; COG0388.	L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.	0.495
CL1_0744	CL1_1122	CL1_0744	CL1_1122	Putative carbon-nitrogen hydrolase; COG0388.	4-aminobutyrate aminotransferase 2; COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.950
CL1_0744	CL1_1355	CL1_0744	CL1_1355	Putative carbon-nitrogen hydrolase; COG0388.	Nicotinate phosphoribosyltransferase; COG1488.	0.637
CL1_0744	CL1_1361	CL1_0744	CL1_1361	Putative carbon-nitrogen hydrolase; COG0388.	Hypothetical protein; COG1701.	0.900