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surE surE purC purC CL1_0204 CL1_0204 upp upp guaAA guaAA guaAB guaAB purL purL purQ purQ purS purS purD purD purE purE purT purT purM purM purC-2 purC-2 purF purF guaB guaB CL1_0909 CL1_0909 pyrC pyrC pyrK pyrK CL1_1106 CL1_1106 pyrE pyrE pyrB pyrB CL1_1359 CL1_1359 CL1_1360 CL1_1360 pyrD pyrD pyrH pyrH CL1_1439 CL1_1439 CL1_1440 CL1_1440 pyrF pyrF CL1_1601 CL1_1601 CL1_1777 CL1_1777 purA purA glmS glmS
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second shell of interactors
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surEPutative stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (257 aa)
purCPutative phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase; COG0152; Belongs to the SAICAR synthetase family. (219 aa)
CL1_0204Putative xanthine/uracil permease 1; COG2233. (433 aa)
uppPutative uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (222 aa)
guaAAGMP synthase subunit A; Catalyzes the synthesis of GMP from XMP. (189 aa)
guaABGMP synthase subunit B; Catalyzes the synthesis of GMP from XMP. (307 aa)
purLPhosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and [...] (713 aa)
purQPhosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interac [...] (223 aa)
purSPhosphoribosylformylglycinamidine (FGAM) synthase, PurS component; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and i [...] (80 aa)
purDPhosphoribosylamine-glycine ligase; COG0151; Belongs to the GARS family. (438 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (143 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (429 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; COG0150. (334 aa)
purC-2Phosphoribosylaminoimidazole-succinocarboxamide synthase; COG0152; Belongs to the SAICAR synthetase family. (231 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (444 aa)
guaBInosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa)
CL1_0909Glutamine synthetase; COG0174; Belongs to the glutamine synthetase family. (440 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (410 aa)
pyrKDihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (233 aa)
CL1_1106HamI-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (184 aa)
pyrEPutative orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (186 aa)
pyrBAspartate carbamoyltransferase catalytic subunit; COG0540. (311 aa)
CL1_1359Glutamate synthase small subunit-like protein; COG0493. (477 aa)
CL1_1360ferredoxin-NADP(+) reductase subunit alpha 1; COG0543. (280 aa)
pyrDPutative dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (301 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (225 aa)
CL1_1439Putative oxidoreductase; COG0493. (480 aa)
CL1_1440ferredoxin-NADP(+) reductase subunit alpha 2; COG0543. (288 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (210 aa)
CL1_1601Asparagine synthase; COG0367. (480 aa)
CL1_1777Adenylosuccinate lyase; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (451 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (339 aa)
glmSGlucosamine-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (602 aa)
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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