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mfnA mfnA atpE atpE atpC atpC atpF atpF atpA atpA atpB atpB atpD atpD pyrK pyrK pyrD pyrD pyrH pyrH CL1_1414 CL1_1414 CL1_1440 CL1_1440 ribL ribL pyrF pyrF tdk tdk CL1_1539 CL1_1539 CL1_1601 CL1_1601 ndk ndk CL1_1777 CL1_1777 purA purA CL1_1885 CL1_1885 adk adk panB panB CL1_2037 CL1_2037 CL1_1361 CL1_1361 pyrC pyrC nadE nadE CL1_0863 CL1_0863 CL1_0818 CL1_0818 guaB guaB CL1_0800 CL1_0800 nadA nadA CL1_0797 CL1_0797 purF purF purC-2 purC-2 purM purM purT purT purE purE purD purD CL1_0784 CL1_0784 purS purS purQ purQ purL purL purP purP guaAB guaAB guaAA guaAA CL1_0760 CL1_0760 CL1_0642 CL1_0642 adkA adkA cmk cmk CL1_0579 CL1_0579 CL1_0571 CL1_0571 upp upp CL1_0493 CL1_0493 tmk tmk dcd dcd pyrG pyrG CL1_0298 CL1_0298 thyX thyX CL1_0142 CL1_0142 ribK ribK CL1_0125 CL1_0125 CL1_0085 CL1_0085 purO purO CL1_0040 CL1_0040 purC purC CL1_0028 CL1_0028 CL1_0010 CL1_0010 CL1_0007 CL1_0007 CL1_1360 CL1_1360 CL1_1355 CL1_1355 CL1_1330 CL1_1330 prs prs pyrB pyrB pyrI pyrI CL1_1259 CL1_1259 CL1_1249 CL1_1249 CL1_1248 CL1_1248 CL1_1245 CL1_1245 pyrE pyrE CL1_1196 CL1_1196 CL1_1133 CL1_1133 CL1_1131 CL1_1131 nadK nadK CL1_1084 CL1_1084
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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mfnATyrosine decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (384 aa)
atpEV-type ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (203 aa)
atpCV-type ATP synthase subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane. (366 aa)
atpFV-type ATP synthase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane. (102 aa)
atpAV-type ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (585 aa)
atpBV-type ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (460 aa)
atpDV-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (217 aa)
pyrKDihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (233 aa)
pyrDPutative dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (301 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (225 aa)
CL1_1414Indolepyruvate ferredoxin oxidoreductase, beta subunit 2; COG1014. (202 aa)
CL1_1440ferredoxin-NADP(+) reductase subunit alpha 2; COG0543. (288 aa)
ribLGlycerol-3-phosphate cytidylyltransferase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (151 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (210 aa)
tdkThymidine kinase; COG1435. (193 aa)
CL1_1539Archaeal nicotinamide-nucleotide adenylyltransferase; COG1056. (187 aa)
CL1_1601Asparagine synthase; COG0367. (480 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (174 aa)
CL1_1777Adenylosuccinate lyase; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (451 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (339 aa)
CL1_1885Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; COG0452. (405 aa)
adkPutative adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (223 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (285 aa)
CL1_2037Putative adenylate cyclase 2; COG1437. (171 aa)
CL1_1361Hypothetical protein; COG1701. (260 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (410 aa)
nadEPutative NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (254 aa)
CL1_0863Hypothetical protein containing phosphoribosyltransferase-lilke domain 2; COG2236. (154 aa)
CL1_0818Anaerobic ribonucleoside triphosphate reductase; COG1328. (614 aa)
guaBInosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa)
CL1_0800L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (465 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (302 aa)
CL1_0797Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (277 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (444 aa)
purC-2Phosphoribosylaminoimidazole-succinocarboxamide synthase; COG0152; Belongs to the SAICAR synthetase family. (231 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; COG0150. (334 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (429 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (143 aa)
purDPhosphoribosylamine-glycine ligase; COG0151; Belongs to the GARS family. (438 aa)
CL1_07845-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase 3; COG1759. (380 aa)
purSPhosphoribosylformylglycinamidine (FGAM) synthase, PurS component; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and i [...] (80 aa)
purQPhosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interac [...] (223 aa)
purLPhosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and [...] (713 aa)
purP5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase 2; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (331 aa)
guaABGMP synthase subunit B; Catalyzes the synthesis of GMP from XMP. (307 aa)
guaAAGMP synthase subunit A; Catalyzes the synthesis of GMP from XMP. (189 aa)
CL1_0760Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (176 aa)
CL1_0642Sulfhydrogenase II, gamma chain; COG0543. (288 aa)
adkAPutative adenylate kinase; COG2019; Belongs to the archaeal adenylate kinase family. (196 aa)
cmkPutative cytidylate kinase; COG1102. (197 aa)
CL1_0579Hypothetical protein containing phosphoribosyltransferase-lilke domain 1; COG0503. (238 aa)
CL1_0571Uridine phosphorylase (udp); Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (278 aa)
uppPutative uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (222 aa)
CL1_0493Putative ATP-NAD kinase; COG3199. (377 aa)
tmkThymidylate kinase; COG0125. (205 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (156 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa)
CL1_0298Putative adenylate cyclase 1; COG1437. (177 aa)
thyXPutative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (250 aa)
CL1_0142Cytosolic NiFe-hydrogenase subunit gamma; COG0543. (294 aa)
ribKPutative transcription regulator, MarR family 1; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (212 aa)
CL1_0125Putative kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (179 aa)
CL1_0085Competence damage-inducible protein A; COG1058; Belongs to the CinA family. (252 aa)
purOPutative Inosine monophosphate cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (184 aa)
CL1_00405-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase 1; COG1759. (310 aa)
purCPutative phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase; COG0152; Belongs to the SAICAR synthetase family. (219 aa)
CL1_0028Putative phosphoribosyltransferase; COG2236. (215 aa)
CL1_00102-oxoglutarate ferredoxin oxidoreductase subunit gamma 2; COG1014. (170 aa)
CL1_00072-oxoglutarate ferredoxin oxidoreductase subunit gamma 1; COG1014. (186 aa)
CL1_1360ferredoxin-NADP(+) reductase subunit alpha 1; COG0543. (280 aa)
CL1_1355Nicotinate phosphoribosyltransferase; COG1488. (390 aa)
CL1_1330Indolepyruvate ferredoxin oxidoreductase, beta subunit 1; COG1014. (194 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (279 aa)
pyrBAspartate carbamoyltransferase catalytic subunit; COG0540. (311 aa)
pyrIAspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (151 aa)
CL1_12592-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (302 aa)
CL1_1249Pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; COG1014. (185 aa)
CL1_12482-ketoisovalerate ferredoxin oxidoreductase subunit delta; COG1144. (108 aa)
CL1_1245Pyruvate ferredoxin oxidoreductase subunit delta; COG1144. (105 aa)
pyrEPutative orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (186 aa)
CL1_1196GHMP kinase 2; COG1829. (300 aa)
CL1_1133NADH-ubiquinone oxidoreductase subunit 4; COG3260. (172 aa)
CL1_1131NADH-ubiquinone oxidoreductase subunit 2; COG3261. (425 aa)
nadKNAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (278 aa)
CL1_1084Phosphopantetheine adenylyltransferase; COG1019. (189 aa)
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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