STRINGSTRING
surE surE thyX thyX pyrG pyrG dcd dcd tmk tmk upp upp CL1_0571 CL1_0571 cmk cmk CL1_0744 CL1_0744 CL1_0818 CL1_0818 CL1_0862 CL1_0862 pyrC pyrC pyrK pyrK CL1_1013 CL1_1013 pyrE pyrE pyrI pyrI pyrB pyrB CL1_1344 CL1_1344 pyrD pyrD pyrH pyrH pyrF pyrF tdk tdk ndk ndk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
surEPutative stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (257 aa)
thyXPutative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (250 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (156 aa)
tmkThymidylate kinase; COG0125. (205 aa)
uppPutative uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (222 aa)
CL1_0571Uridine phosphorylase (udp); Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (278 aa)
cmkPutative cytidylate kinase; COG1102. (197 aa)
CL1_0744Putative carbon-nitrogen hydrolase; COG0388. (264 aa)
CL1_0818Anaerobic ribonucleoside triphosphate reductase; COG1328. (614 aa)
CL1_0862Ribonucleoside-diphosphate reductase subunit alpha; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (906 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (410 aa)
pyrKDihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (233 aa)
CL1_1013Hypothetical protein containing ribokinase-like domain 1; COG0524; Belongs to the carbohydrate kinase PfkB family. (277 aa)
pyrEPutative orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (186 aa)
pyrIAspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (151 aa)
pyrBAspartate carbamoyltransferase catalytic subunit; COG0540. (311 aa)
CL1_1344Deoxycytidylate deaminase; COG2131. (178 aa)
pyrDPutative dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (301 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (225 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (210 aa)
tdkThymidine kinase; COG1435. (193 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (174 aa)
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.