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ndk ndk hpt hpt pyrF pyrF metH_1 metH_1 metH_2 metH_2 pyrE pyrE guaB guaB purF purF surE_1 surE_1 pyrC pyrC pyrB pyrB AMV24103.1 AMV24103.1 purH purH pyrG pyrG purL_1 purL_1 rsh rsh amn amn purB purB purC purC folD folD thiL thiL upp upp pyrK pyrK surE_2 surE_2 metF metF metK metK pyrH pyrH ybdL ybdL carB carB purL_2 purL_2 tmk tmk adk_1 adk_1 nrdJ nrdJ dcd dcd purA purA nrdB nrdB nrdA nrdA glyA glyA purK purK purE purE guaA guaA purM purM adk_2 adk_2 gmk gmk AMV29469.1 AMV29469.1 pyrD pyrD carA carA apt apt rsgA rsgA purD purD purN purN thyX thyX
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (148 aa)
hptHypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (171 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (298 aa)
metH_1Methionine synthase. (275 aa)
metH_2Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (940 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (182 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (497 aa)
purFAmidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (540 aa)
surE_15'-nucleotidase SurE. (229 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (440 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (304 aa)
AMV24103.1Hypothetical protein. (322 aa)
purHBifunctional purine biosynthesis protein PurH. (526 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (544 aa)
purL_1Phosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (960 aa)
rshGTP pyrophosphokinase rsh. (173 aa)
amnAMP nucleosidase. (260 aa)
purBAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (498 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (292 aa)
folDBifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (291 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (346 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
pyrKDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit. (273 aa)
surE_25'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa)
metF5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (301 aa)
metKS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (421 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (246 aa)
ybdLMethionine aminotransferase. (285 aa)
carBCarbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1105 aa)
purL_2Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (257 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa)
adk_1Adenylate kinase. (350 aa)
nrdJVitamin B12-dependent ribonucleotide reductase. (1617 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (185 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
nrdBRibonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (332 aa)
nrdARibonucleoside-diphosphate reductase 1 subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (770 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa)
purKN5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (364 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (182 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (514 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (357 aa)
adk_2Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (225 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (218 aa)
AMV29469.1Hypothetical protein. (504 aa)
pyrDDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (304 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (368 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
rsgAPutative ribosome biogenesis GTPase RsgA; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (411 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (473 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (206 aa)
thyXThymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (284 aa)
Your Current Organism:
Gemmata sp. SHPL17
NCBI taxonomy Id: 1630693
Other names: G. sp. SH-PL17, Gemmata sp. SH-PL17
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