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| | icd_2 | Isocitrate dehydrogenase [NADP]. (340 aa) |
| | hicd | Homoisocitrate dehydrogenase. (91 aa) |
| | icd_3 | Isocitrate dehydrogenase [NADP]. (234 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (337 aa) |
| | folA | Dihydrofolate reductase. (174 aa) |
| | ino1 | Inositol-3-phosphate synthase. (399 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (361 aa) |
| | yciC | Putative metal chaperone YciC. (403 aa) |
| | AMV28359.1 | 1,4-dihydroxy-2-naphthoyl-CoA hydrolase. (139 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (319 aa) |
| | ilvB | Acetolactate synthase isozyme 1 large subunit. (187 aa) |
| | AMV28418.1 | Hypothetical protein. (320 aa) |
| | gnl_4 | Gluconolactonase precursor. (349 aa) |
| | AMV28517.1 | Fatty acid desaturase. (274 aa) |
| | fabF_2 | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (439 aa) |
| | fabF_3 | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (430 aa) |
| | pgi_1 | Glucose-6-phosphate isomerase. (501 aa) |
| | dapA_4 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (153 aa) |
| | dapA_5 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (300 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (610 aa) |
| | thrC_3 | Threonine synthase. (423 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI. (293 aa) |
| | serA_3 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa) |
| | AMV28693.1 | Hypothetical protein. (790 aa) |
| | AMV28701.1 | Hypothetical protein. (446 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (276 aa) |
| | AMV28850.1 | Hypothetical protein. (160 aa) |
| | patA_1 | Peptidoglycan O-acetyltransferase; Belongs to the membrane-bound acyltransferase family. (512 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (247 aa) |
| | pqsD | PQB biosynthetic 3-oxoacyl-[acyl-carrier-protein] synthase III. (385 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (335 aa) |
| | AMV29017.1 | CobW/HypB/UreG, nucleotide-binding domain. (303 aa) |
| | yjiA_2 | Putative GTP-binding protein YjiA. (90 aa) |
| | queG | Epoxyqueuosine reductase. (442 aa) |
| | mqnD | 1,4-dihydroxy-6-naphtoate synthase; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (288 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (432 aa) |
| | asd2 | Aspartate-semialdehyde dehydrogenase 2; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (291 aa) |
| | pheA | Prephenate dehydratase. (377 aa) |
| | aroF_1 | Phospho-2-dehydro-3-deoxyheptonate aldolase. (343 aa) |
| | pgk/tpi | Bifunctional PGK/TIM; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa) |
| | AMV29156.1 | Homoserine kinase. (326 aa) |
| | AMV29178.1 | Hypothetical protein. (147 aa) |
| | qorA_2 | Quinone oxidoreductase 1. (332 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (396 aa) |
| | sir | Sulfite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa) |
| | ilvB1 | Acetolactate synthase large subunit IlvB1. (589 aa) |
| | AMV29263.1 | Cob(I)yrinic acid a,c-diamide adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (191 aa) |
| | fabD_2 | Malonyl CoA-acyl carrier protein transacylase. (302 aa) |
| | acpP_2 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (81 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (637 aa) |
| | AMV29786.1 | Hypothetical protein. (169 aa) |
| | hom | Homoserine dehydrogenase. (467 aa) |
| | yliI_3 | Soluble aldose sugar dehydrogenase YliI precursor. (672 aa) |
| | AMV29908.1 | Prenyltransferase; Belongs to the UbiA prenyltransferase family. (159 aa) |
| | AMV29909.1 | Prenyltransferase; Belongs to the UbiA prenyltransferase family. (144 aa) |
| | queC_3 | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (238 aa) |
| | queD | 6-carboxy-5,6,7,8-tetrahydropterin synthase. (158 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (288 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (368 aa) |
| | gnl_5 | Gluconolactonase precursor. (569 aa) |
| | AMV30003.1 | Hypothetical protein. (191 aa) |
| | AMV30052.1 | Hypothetical protein. (574 aa) |
| | cysE_2 | Serine acetyltransferase. (329 aa) |
| | bioF | 8-amino-7-oxononanoate synthase. (420 aa) |
| | cysK1_2 | O-acetylserine sulfhydrylase. (330 aa) |
| | crnA_2 | Creatinine amidohydrolase. (253 aa) |
| | AMV30217.1 | Hypothetical protein. (203 aa) |
| | aroF_2 | Phospho-2-dehydro-3-deoxyheptonate aldolase. (337 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (342 aa) |
| | dmlA | D-malate dehydrogenase. (354 aa) |
| | folE | GTP cyclohydrolase 1. (212 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (126 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (342 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa) |
| | yycJ | Putative metallo-hydrolase YycJ. (311 aa) |
| | mqnE_2 | Aminodeoxyfutalosine synthase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (381 aa) |
| | mqnA | Chorismate dehydratase; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (279 aa) |
| | dmdB | 2,3-dimethylmalate dehydratase small subunit; Belongs to the LeuD family. (189 aa) |
| | accB | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (177 aa) |
| | fabF_5 | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (429 aa) |
| | fabF_6 | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (423 aa) |
| | fabZ_2 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ. (162 aa) |
| | acpP_3 | Acyl carrier protein. (130 aa) |
| | fabZ_3 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ. (163 aa) |
| | AMV30444.1 | Branched-chain amino acid aminotransferase. (320 aa) |
| | pgi_2 | Glucose-6-phosphate isomerase; Belongs to the GPI family. (544 aa) |
| | sirC | Precorrin-2 dehydrogenase. (199 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | AMV29615.1 | Haloacid dehalogenase-like hydrolase. (335 aa) |
| | AMV29666.1 | Prenyltransferase. (309 aa) |
| | fabF_4 | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (430 aa) |
| | argE | Acetylornithine deacetylase. (383 aa) |
| | hpt | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (171 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (125 aa) |
| | queC_1 | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (226 aa) |
| | AMV22849.1 | Glyoxalase-like domain protein. (154 aa) |
| | ribF | Riboflavin biosynthesis protein RibF; Belongs to the ribF family. (316 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (268 aa) |
| | cysK_1 | Cysteine synthase. (313 aa) |
| | metH_1 | Methionine synthase. (275 aa) |
| | metH_2 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (940 aa) |
| | glnA_1 | Glutamine synthetase. (478 aa) |
| | fabH_1 | 3-oxoacyl-[acyl-carrier-protein] synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (333 aa) |
| | asnB | Asparagine synthetase 1. (667 aa) |
| | AMV23147.1 | Putative pterin-4-alpha-carbinolamine dehydratase. (115 aa) |
| | mqnE_1 | Aminodeoxyfutalosine synthase; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (380 aa) |
| | AMV23188.1 | Glyoxalase-like domain protein. (155 aa) |
| | dmdA | 2,3-dimethylmalate dehydratase large subunit; Belongs to the aconitase/IPM isomerase family. (434 aa) |
| | ilvH | Putative acetolactate synthase small subunit. (168 aa) |
| | moaA_1 | Cyclic pyranopterin monophosphate synthase. (426 aa) |
| | ilvG | Acetolactate synthase isozyme 2 large subunit; Belongs to the TPP enzyme family. (630 aa) |
| | argA | Amino-acid acetyltransferase; Belongs to the acetyltransferase family. (460 aa) |
| | AMV23413.1 | Hypothetical protein. (325 aa) |
| | AMV23468.1 | Hypothetical protein. (440 aa) |
| | panD | Aspartate 1-decarboxylase precursor; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (119 aa) |
| | ilvD_1 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (651 aa) |
| | fabH_2 | 3-oxoacyl-[acyl-carrier-protein] synthase 3. (623 aa) |
| | pdxA2 | 4-hydroxythreonine-4-phosphate dehydrogenase 2; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (335 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (279 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (369 aa) |
| | ribD | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (363 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (427 aa) |
| | AMV24207.1 | Hypothetical protein. (234 aa) |
| | tuaD | UDP-glucose 6-dehydrogenase TuaD. (443 aa) |
| | AMV24258.1 | Pterin binding enzyme. (471 aa) |
| | dapA_1 | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa) |
| | AMV24360.1 | Acetyltransferase (GNAT) family protein. (150 aa) |
| | dat | D-alanine aminotransferase. (282 aa) |
| | AMV24405.1 | Phenolphthiocerol synthesis polyketide synthase type I Pks15/1. (2530 aa) |
| | fabD_1 | Malonyl CoA-acyl carrier protein transacylase. (1114 aa) |
| | AMV24407.1 | Hypothetical protein. (91 aa) |
| | tdcB | L-threonine dehydratase catabolic TdcB. (318 aa) |
| | AMV24470.1 | Acetyltransferase (GNAT) family protein. (185 aa) |
| | acpS | Holo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (140 aa) |
| | AMV24670.1 | 6-pyruvoyl tetrahydropterin synthase. (163 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (242 aa) |
| | AMV24696.1 | Cyclohexadienyl dehydrogenase. (281 aa) |
| | pdxH | Pyridoxine/pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (245 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (217 aa) |
| | AMV24786.1 | Putative molybdenum carrier. (159 aa) |
| | amn | AMP nucleosidase. (260 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (260 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (272 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (401 aa) |
| | pflA | Pyruvate formate-lyase 1-activating enzyme. (227 aa) |
| | hisA_1 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Belongs to the HisA/HisF family. (252 aa) |
| | AMV24931.1 | Molybdenum cofactor biosynthesis protein A. (765 aa) |
| | AMV24963.1 | Hypothetical protein. (436 aa) |
| | gltS | Ferredoxin-dependent glutamate synthase 2. (1590 aa) |
| | adhT_1 | Alcohol dehydrogenase. (331 aa) |
| | tagD | Glycerol-3-phosphate cytidylyltransferase. (309 aa) |
| | queC_2 | 7-cyano-7-deazaguanine synthase. (593 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (377 aa) |
| | gltB_1 | Ferredoxin-dependent glutamate synthase 1. (1523 aa) |
| | cysK1_1 | O-acetylserine sulfhydrylase. (313 aa) |
| | AMV25571.1 | RNA cap guanine-N2 methyltransferase. (425 aa) |
| | phnP | Phosphoribosyl 1,2-cyclic phosphodiesterase. (266 aa) |
| | yxeP | Putative hydrolase YxeP. (467 aa) |
| | thrC_1 | Threonine synthase. (407 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (392 aa) |
| | fabF_1 | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (430 aa) |
| | AMV25774.1 | 4-hydroxybenzoate decarboxylase subunit C; Belongs to the UbiD family. (649 aa) |
| | leuA_2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (528 aa) |
| | folD | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (291 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (442 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (346 aa) |
| | gnl_2 | Gluconolactonase precursor. (312 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (296 aa) |
| | queE | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (238 aa) |
| | AMV26020.1 | Hypothetical protein. (448 aa) |
| | ubiB | Putative protein kinase UbiB. (564 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (352 aa) |
| | AMV26144.1 | Cobalt transport protein CbiM. (221 aa) |
| | ybgC | Acyl-CoA thioester hydrolase YbgC. (128 aa) |
| | ilvD_2 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (560 aa) |
| | adhT_2 | Alcohol dehydrogenase. (334 aa) |
| | AMV26326.1 | Asparagine synthetase B. (447 aa) |
| | gnl_3 | Gluconolactonase precursor. (878 aa) |
| | srp54_2 | Signal recognition particle 54 kDa protein. (368 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa) |
| | AMV26430.1 | Pyrroloquinoline quinone biosynthesis protein PqqE. (382 aa) |
| | cfiB | 2-oxoglutarate carboxylase small subunit; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1157 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | ilvC | Ketol-acid reductoisomerase. (349 aa) |
| | AMV26552.1 | SMP-30/Gluconolaconase/LRE-like region. (324 aa) |
| | AMV26586.1 | Hypothetical protein. (399 aa) |
| | AMV26661.1 | Hypothetical protein. (178 aa) |
| | lysC | Aspartokinase. (630 aa) |
| | thiE | Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (494 aa) |
| | dapE | Putative succinyl-diaminopimelate desuccinylase. (466 aa) |
| | AMV26752.1 | Hypothetical protein. (182 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (286 aa) |
| | hisA_2 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (240 aa) |
| | fabH_3 | 3-oxoacyl-[acyl-carrier-protein] synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (339 aa) |
| | AMV26850.1 | Hypothetical protein. (154 aa) |
| | crnA_1 | Creatinine amidohydrolase. (290 aa) |
| | dapA_2 | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa) |
| | ribE | Riboflavin synthase. (200 aa) |
| | AMV27008.1 | Pyrroloquinoline quinone biosynthesis protein PqqE. (421 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (347 aa) |
| | dapA_3 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (305 aa) |
| | serS | Serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (431 aa) |
| | acpH | Acyl carrier protein phosphodiesterase. (211 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (474 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (345 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | aroL | Shikimate kinase 2; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (180 aa) |
| | hisH1 | Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (206 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1105 aa) |
| | desA1 | Putative acyl-[acyl-carrier-protein] desaturase desA1. (263 aa) |
| | fabZ_1 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ. (169 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (322 aa) |
| | argF | Ornithine carbamoyltransferase. (303 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (403 aa) |
| | argB | Acetylglutamate kinase. (287 aa) |
| | qorA_1 | Quinone oxidoreductase 1. (324 aa) |
| | cysK_2 | Cysteine synthase. (314 aa) |
| | aroG | Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (373 aa) |
| | ilvA | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (506 aa) |
| | AMV27611.1 | Hypothetical protein. (443 aa) |
| | yafP | Putative N-acetyltransferase YafP. (157 aa) |
| | proA_2 | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (429 aa) |
| | folP | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (282 aa) |
| | abgB | P-aminobenzoyl-glutamate hydrolase subunit B. (479 aa) |
| | uppS | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (257 aa) |
| | cysE_1 | Serine acetyltransferase. (181 aa) |
| | AMV27796.1 | 2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate phosphatase. (224 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (419 aa) |
| | araD | L-2-keto-3-deoxyarabonate dehydratase; Belongs to the DapA family. (305 aa) |
| | serA_1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (337 aa) |
| | argH1 | Argininosuccinate lyase 1. (459 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (437 aa) |
| | yjiA_1 | Putative GTP-binding protein YjiA. (386 aa) |
| | serA_2 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (539 aa) |
| | thrC_2 | Threonine synthase. (464 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (263 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa) |
| | panE | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (314 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (385 aa) |
| | nanA | N-acetylneuraminate lyase. (309 aa) |
