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glyA glyA metH metH metK metK lipM lipM gcvH_1 gcvH_1 gcvT gcvT putA putA lipA lipA gdhA_1 gdhA_1 ybdK ybdK dfrA dfrA gcvP gcvP lplJ lplJ glnA glnA gltB_1 gltB_1 gltB_2 gltB_2 proB proB hmp_2 hmp_2 ggt ggt gcvH_2 gcvH_2 AMV33937.1 AMV33937.1 glnII glnII apc3 apc3 ywrD ywrD thyA thyA folD folD purU purU metF metF proA proA gdhA_2 gdhA_2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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gene co-occurrence
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glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
metHMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1234 aa)
metKS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (429 aa)
lipMOctanoyltransferase LipM. (252 aa)
gcvH_1Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (374 aa)
putABifunctional protein PutA; Belongs to the aldehyde dehydrogenase family. (1084 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (356 aa)
gdhA_1Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (412 aa)
ybdKCarboxylate-amine ligase YbdK; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (385 aa)
dfrADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (165 aa)
gcvPGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (949 aa)
lplJLipoate-protein ligase LplJ. (275 aa)
glnAGlutamine synthetase 1. (397 aa)
gltB_1Glutamate synthase [NADPH] small chain. (500 aa)
gltB_2Ferredoxin-dependent glutamate synthase 1. (1519 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (376 aa)
hmp_2Flavohemoprotein. (424 aa)
ggtGamma-glutamyltranspeptidase precursor. (590 aa)
gcvH_2Glycine cleavage system H protein. (160 aa)
AMV33937.1Branched-chain alpha-keto acid dehydrogenase subunit E2. (248 aa)
glnIIGlutamine synthetase 2. (337 aa)
apc3Acetophenone carboxylase gamma subunit. (1291 aa)
ywrDPutative gamma-glutamyltransferase YwrD. (584 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (265 aa)
folDBifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (292 aa)
purUFormyltetrahydrofolate deformylase. (287 aa)
metF5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (288 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (426 aa)
gdhA_2NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (448 aa)
Your Current Organism:
Pirellula sp. SHSr6A
NCBI taxonomy Id: 1632865
Other names: P. sp. SH-Sr6A, Pirellula sp. SH-Sr6A
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