STRINGSTRING
ilvC ilvC tuaD tuaD tdh tdh fdhA_1 fdhA_1 mdh mdh lhgO lhgO hprA_1 hprA_1 zwf zwf dhaT_1 dhaT_1 fdhA_2 fdhA_2 yahK_1 yahK_1 yahK_2 yahK_2 ldhA ldhA rmlD_1 rmlD_1 hisD hisD icd icd serA_1 serA_1 pdxA2 pdxA2 dxr dxr ghrB ghrB hicd hicd ldh ldh serA_2 serA_2 tkrA tkrA gcd gcd hom hom hprA_2 hprA_2 dhaT_2 dhaT_2 egsA_1 egsA_1 egsA_2 egsA_2 rmlD_2 rmlD_2 murB murB gndA gndA ribD ribD gpsA gpsA betA betA glpD glpD wbpA_2 wbpA_2 leuB leuB guaB_2 guaB_2 wbpA_1 wbpA_1 AMV37560.1 AMV37560.1 AMV37561.1 AMV37561.1 adh adh hpsN hpsN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa)
tuaDUDP-glucose 6-dehydrogenase TuaD. (441 aa)
tdhL-threonine 3-dehydrogenase. (349 aa)
fdhA_1Glutathione-independent formaldehyde dehydrogenase. (406 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (331 aa)
lhgOL-2-hydroxyglutarate oxidase LhgO. (400 aa)
hprA_1Glycerate dehydrogenase. (348 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (524 aa)
dhaT_11,3-propanediol dehydrogenase. (373 aa)
fdhA_2Glutathione-independent formaldehyde dehydrogenase. (389 aa)
yahK_1Aldehyde reductase YahK. (162 aa)
yahK_2Aldehyde reductase YahK. (170 aa)
ldhAD-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (335 aa)
rmlD_1dTDP-4-dehydrorhamnose reductase. (295 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (455 aa)
icdIsocitrate dehydrogenase [NADP]. (432 aa)
serA_1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (323 aa)
pdxA24-hydroxythreonine-4-phosphate dehydrogenase 2; Belongs to the PdxA family. (350 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (389 aa)
ghrBGlyoxylate/hydroxypyruvate reductase B. (335 aa)
hicdHomoisocitrate dehydrogenase. (353 aa)
ldhL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (350 aa)
serA_2D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (544 aa)
tkrAGlyoxylate/hydroxypyruvate reductase B; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (314 aa)
gcdQuinoprotein glucose dehydrogenase. (628 aa)
homHomoserine dehydrogenase. (350 aa)
hprA_2Glycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa)
dhaT_21,3-propanediol dehydrogenase. (384 aa)
egsA_1Glycerol-1-phosphate dehydrogenase [NAD(P)+]. (362 aa)
egsA_2Glycerol-1-phosphate dehydrogenase [NAD(P)+]. (461 aa)
rmlD_2dTDP-4-dehydrorhamnose reductase. (328 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (294 aa)
gndA6-phosphogluconate dehydrogenase, NADP(+)-dependent, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (488 aa)
ribDRiboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (395 aa)
gpsAGlycerol-3-phosphate dehydrogenase [NAD(P)+]; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (332 aa)
betAOxygen-dependent choline dehydrogenase. (1590 aa)
glpDAerobic glycerol-3-phosphate dehydrogenase. (531 aa)
wbpA_2UDP-N-acetyl-D-glucosamine 6-dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (404 aa)
leuB3-isopropylmalate dehydrogenase. (372 aa)
guaB_2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (501 aa)
wbpA_1UDP-N-acetyl-D-glucosamine 6-dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (440 aa)
AMV37560.12-dehydropantoate 2-reductase. (73 aa)
AMV37561.12-dehydropantoate 2-reductase. (240 aa)
adhNADP-dependent isopropanol dehydrogenase. (355 aa)
hpsNSulfopropanediol 3-dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (442 aa)
Your Current Organism:
Planctomyces sp. SHPL62
NCBI taxonomy Id: 1636152
Other names: P. sp. SH-PL62, Planctomyces sp. SH-PL62
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.