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| | coaX | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (253 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1078 aa) |
| | AMV35875.1 | Hypothetical protein. (161 aa) |
| | pyk | Pyruvate kinase; Belongs to the pyruvate kinase family. (502 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (199 aa) |
| | fbaB | Fructose-bisphosphate aldolase class 1. (353 aa) |
| | hpt | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (171 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (229 aa) |
| | acpP_1 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | pfp_1 | Pyrophosphate--fructose 6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (341 aa) |
| | accC_1 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa) |
| | AMV36177.1 | Myo-inositol-1-phosphate synthase. (408 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (524 aa) |
| | AMV36303.1 | Hypothetical protein. (154 aa) |
| | rpiA | Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (240 aa) |
| | pncB2 | Nicotinate phosphoribosyltransferase pncB2; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (452 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (349 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (524 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (226 aa) |
| | relA | GTP pyrophosphokinase. (191 aa) |
| | pyrD | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (306 aa) |
| | AMV36452.1 | Putative acyl-CoA thioester hydrolase. (175 aa) |
| | AMV36479.1 | MazG nucleotide pyrophosphohydrolase domain protein. (107 aa) |
| | suhB_1 | Inositol-1-monophosphatase. (267 aa) |
| | pcrC | Perchlorate reductase subunit gamma precursor. (533 aa) |
| | pcs | Phosphatidylcholine synthase. (268 aa) |
| | ribF | Riboflavin biosynthesis protein RibF; Belongs to the ribF family. (316 aa) |
| | AMV36660.1 | Glyoxalase-like domain protein. (127 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (312 aa) |
| | atpC | ATP synthase epsilon chain, sodium ion specific; Produces ATP from ADP in the presence of a proton gradient across the membrane. (147 aa) |
| | atpD | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (479 aa) |
| | atpG | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (302 aa) |
| | atpA | ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (568 aa) |
| | atpH | ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (214 aa) |
| | atpF | ATP synthase subunit b precursor; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (233 aa) |
| | atpE | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (104 aa) |
| | atpB | ATP synthase subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (274 aa) |
| | cdsA | Phosphatidate cytidylyltransferase. (303 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (386 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (445 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (193 aa) |
| | mcsB | Putative ATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in proteins; Belongs to the ATP:guanido phosphotransferase family. (354 aa) |
| | purH | Bifunctional purine biosynthesis protein PurH. (542 aa) |
| | pfp_2 | Pyrophosphate--fructose 6-phosphate 1-phosphotransferase. (431 aa) |
| | preA | NAD-dependent dihydropyrimidine dehydrogenase subunit PreA; Catalyzes the conversion of dihydroorotate to orotate. (335 aa) |
| | sucC | Succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (417 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (436 aa) |
| | pyrB | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (337 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (321 aa) |
| | AMV36955.1 | Prokaryotic diacylglycerol kinase. (180 aa) |
| | AMV36961.1 | Glyoxalase-like domain protein. (137 aa) |
| | pncC | Nicotinamide-nucleotide amidohydrolase PncC; Belongs to the CinA family. (424 aa) |
| | prs | Ribose-phosphate pyrophosphokinase. (326 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (370 aa) |
| | nnr_1 | Bifunctional NAD(P)H-hydrate repair enzyme Nnr; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (304 aa) |
| | AMV37059.1 | AIR carboxylase. (265 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (659 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (389 aa) |
| | AMV37102.1 | Putative metallophosphoesterase. (398 aa) |
| | gmhA1_1 | Phosphoheptose isomerase 1. (206 aa) |
| | pdxH_1 | Pyridoxine/pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (212 aa) |
| | moaC1 | Cyclic pyranopterin monophosphate synthase accessory protein 1; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (164 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (193 aa) |
| | moaB | Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (176 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (151 aa) |
| | AMV37387.1 | Hypothetical protein. (347 aa) |
| | folE | GTP cyclohydrolase 1. (196 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (304 aa) |
| | AMV37492.1 | Hypothetical protein. (309 aa) |
| | lpxD | UDP-3-O-acylglucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (375 aa) |
| | lpxB | Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (414 aa) |
| | AMV37522.1 | Cytidylate kinase. (306 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (520 aa) |
| | AMV37554.1 | Glyoxalase-like domain protein. (127 aa) |
| | surE_1 | 5'-nucleotidase SurE. (251 aa) |
| | AMV37614.1 | Hypothetical protein. (298 aa) |
| | nadB_1 | L-aspartate oxidase. (435 aa) |
| | nadB_2 | L-aspartate oxidase. (112 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (355 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (414 aa) |
| | dcd | Deoxycytidine triphosphate deaminase. (202 aa) |
| | pyrK_1 | Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit. (302 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (167 aa) |
| | purK | N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (384 aa) |
| | AMV37728.1 | Branched-chain alpha-keto acid dehydrogenase subunit E2. (281 aa) |
| | AMV37749.1 | Hypothetical protein; Belongs to the UPF0301 (AlgH) family. (185 aa) |
| | fdhD | Formate dehydrogenase accessory protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (298 aa) |
| | yfkN_1 | Trifunctional nucleotide phosphoesterase protein YfkN precursor; Belongs to the 5'-nucleotidase family. (538 aa) |
| | AMV37972.1 | Bacterial transferase hexapeptide (six repeats). (437 aa) |
| | yhdE | Maf-like protein YhdE; Belongs to the Maf family. (175 aa) |
| | AMV38005.1 | Glyoxalase-like domain protein. (138 aa) |
| | AMV38025.1 | Phosphopantothenate--cysteine ligase. (244 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa) |
| | AMV38066.1 | DisA bacterial checkpoint controller nucleotide-binding protein. (299 aa) |
| | dagK | Diacylglycerol kinase. (350 aa) |
| | AMV38256.1 | Soluble hydrogenase 42 kDa subunit. (384 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (346 aa) |
| | pgl_1 | 6-phosphogluconolactonase. (421 aa) |
| | pgsA | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (204 aa) |
| | adk_1 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (251 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (324 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (332 aa) |
| | AMV38509.1 | Cofactor-independent phosphoglycerate mutase. (341 aa) |
| | glmU | Bifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (423 aa) |
| | xylB_1 | Xylulose kinase. (113 aa) |
| | araB | Ribulokinase. (407 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (161 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa) |
| | gmhA1_2 | Phosphoheptose isomerase 1. (189 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (262 aa) |
| | coaBC | Coenzyme A biosynthesis bifunctional protein CoaBC. (212 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (176 aa) |
| | adk_2 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (228 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (281 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (396 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (292 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (258 aa) |
| | purL_1 | Phosphoribosylformylglycinamidine synthase 2. (326 aa) |
| | purL_2 | Phosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (629 aa) |
| | AMV38927.1 | Diadenosine tetraphosphatase. (222 aa) |
| | yceF | Maf-like protein YceF; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. (197 aa) |
| | tkt | Transketolase; Belongs to the transketolase family. (698 aa) |
| | pfkA1_1 | 6-phosphofructokinase 1. (441 aa) |
| | AMV38992.1 | Branched-chain alpha-keto acid dehydrogenase subunit E2. (151 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (230 aa) |
| | AMV39152.1 | Acyltransferase. (280 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (551 aa) |
| | clsA | Major cardiolipin synthase ClsA; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol; Belongs to the phospholipase D family. Cardiolipin synthase subfamily. (510 aa) |
| | pdxH_2 | Pyridoxine/pyridoxamine 5'-phosphate oxidase. (193 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (252 aa) |
| | eno_1 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (441 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (502 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (389 aa) |
| | AMV39422.1 | SpoIVB peptidase S55. (634 aa) |
| | gndA | 6-phosphogluconate dehydrogenase, NADP(+)-dependent, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (488 aa) |
| | pfkA1_2 | 6-phosphofructokinase 1; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (430 aa) |
| | mobA | Putative molybdenum cofactor guanylyltransferase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (214 aa) |
| | lpxA_1 | Acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (274 aa) |
| | moaA | Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (333 aa) |
| | moaE | Molybdopterin synthase catalytic subunit. (138 aa) |
| | nboR | Nicotine blue oxidoreductase. (294 aa) |
| | purF | Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (531 aa) |
| | plsC_1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase. (228 aa) |
| | AMV39616.1 | CDP-alcohol phosphatidyltransferase. (302 aa) |
| | upp | Uracil phosphoribosyltransferase; Belongs to the UPRTase family. (217 aa) |
| | lpxH | UDP-2,3-diacylglucosamine hydrolase. (253 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase [NAD(P)+]; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (332 aa) |
| | cysO | Sulfur carrier protein CysO. (89 aa) |
| | pgk/tpi | Bifunctional PGK/TIM; Belongs to the phosphoglycerate kinase family. (396 aa) |
| | lpxC | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (449 aa) |
| | lpxA_2 | Acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (271 aa) |
| | AMV39785.1 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (222 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (258 aa) |
| | glpD | Aerobic glycerol-3-phosphate dehydrogenase. (531 aa) |
| | AMV39829.1 | Putative glycerol-3-phosphate acyltransferase PlsY; Belongs to the PlsY family. (490 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (358 aa) |
| | AMV39846.1 | CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (355 aa) |
| | folD | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (291 aa) |
| | pdhC | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. (455 aa) |
| | acoA | Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (337 aa) |
| | moeA | Molybdopterin molybdenumtransferase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (408 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (319 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (503 aa) |
| | yfkN_2 | Trifunctional nucleotide phosphoesterase protein YfkN precursor; Belongs to the 5'-nucleotidase family. (540 aa) |
| | AMV40267.1 | lipid-A-disaccharide synthase. (119 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (211 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (259 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (674 aa) |
| | ppnK | Putative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (300 aa) |
| | disA | DNA integrity scanning protein DisA. (348 aa) |
| | eno_2 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (435 aa) |
| | pyrK_2 | Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit. (297 aa) |
| | cmk | Cytidylate kinase. (217 aa) |
| | plsC_2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase. (251 aa) |
| | AMV40543.1 | Hypothetical protein; Belongs to the UPF0301 (AlgH) family. (189 aa) |
| | guaC | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (342 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (300 aa) |
| | suhB_2 | Inositol-1-monophosphatase. (276 aa) |
| | ble | Bleomycin resistance protein. (125 aa) |
| | pgl_2 | 6-phosphogluconolactonase. (401 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa) |
| | guaB_2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (501 aa) |
| | surE_2 | 5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (253 aa) |
| | AMV40795.1 | Putative metallophosphoesterase. (283 aa) |
| | nnr_2 | Bifunctional NAD(P)H-hydrate repair enzyme Nnr; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family. (240 aa) |
