(6 nodes) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain network (Proteiniphilum saccharofermentans)

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Your Input:
	nifJ	Pyruvate dehydrogenase (NADP(+)); Pyruvate + CoA + NADP(+) <=> acetyl-CoA + CO(2) + NADPH; High confidence in function and specificity. (1194 aa)
	vorA	Ketoisovalerate oxidoreductase subunit VorA; 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+; High confidence in function and specificity. (253 aa)
	ilvB	Acetolactate synthase large subunit; 2 pyruvate = 2-acetolactate + CO2; High confidence in function and specificity. (574 aa)
	PSM36_0964	Indolepyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (529 aa)
	korB	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; High confidence in function and specificity. (349 aa)
	acoA	TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha [Energy production and conversion]; High confidence in function and specificity. (330 aa)

Your Current Organism:

Proteiniphilum saccharofermentans

NCBI taxonomy Id: 1642647
Other names: CECT 8610, DSM 28694, LMG 28299, LMG:28299, P. saccharofermentans, Proteiniphilum saccharofermentans Hahnke et al. 2016, Proteiniphilum sp. M3/6, strain M3/6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PSM36_0964	nifJ	PSM36_0964	PSM36_0571	Indolepyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.	Pyruvate dehydrogenase (NADP(+)); Pyruvate + CoA + NADP(+) <=> acetyl-CoA + CO(2) + NADPH; High confidence in function and specificity.	0.879
acoA	ilvB	PSM36_2448	PSM36_0868	TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha [Energy production and conversion]; High confidence in function and specificity.	Acetolactate synthase large subunit; 2 pyruvate = 2-acetolactate + CO2; High confidence in function and specificity.	0.830
acoA	korB	PSM36_2448	PSM36_2331	TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha [Energy production and conversion]; High confidence in function and specificity.	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; High confidence in function and specificity.	0.905
acoA	nifJ	PSM36_2448	PSM36_0571	TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha [Energy production and conversion]; High confidence in function and specificity.	Pyruvate dehydrogenase (NADP(+)); Pyruvate + CoA + NADP(+) <=> acetyl-CoA + CO(2) + NADPH; High confidence in function and specificity.	0.937
acoA	vorA	PSM36_2448	PSM36_0714	TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha [Energy production and conversion]; High confidence in function and specificity.	Ketoisovalerate oxidoreductase subunit VorA; 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+; High confidence in function and specificity.	0.905
ilvB	acoA	PSM36_0868	PSM36_2448	Acetolactate synthase large subunit; 2 pyruvate = 2-acetolactate + CO2; High confidence in function and specificity.	TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha [Energy production and conversion]; High confidence in function and specificity.	0.830
ilvB	korB	PSM36_0868	PSM36_2331	Acetolactate synthase large subunit; 2 pyruvate = 2-acetolactate + CO2; High confidence in function and specificity.	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; High confidence in function and specificity.	0.913
ilvB	nifJ	PSM36_0868	PSM36_0571	Acetolactate synthase large subunit; 2 pyruvate = 2-acetolactate + CO2; High confidence in function and specificity.	Pyruvate dehydrogenase (NADP(+)); Pyruvate + CoA + NADP(+) <=> acetyl-CoA + CO(2) + NADPH; High confidence in function and specificity.	0.966
ilvB	vorA	PSM36_0868	PSM36_0714	Acetolactate synthase large subunit; 2 pyruvate = 2-acetolactate + CO2; High confidence in function and specificity.	Ketoisovalerate oxidoreductase subunit VorA; 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+; High confidence in function and specificity.	0.913
korB	acoA	PSM36_2331	PSM36_2448	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; High confidence in function and specificity.	TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha [Energy production and conversion]; High confidence in function and specificity.	0.905
korB	ilvB	PSM36_2331	PSM36_0868	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; High confidence in function and specificity.	Acetolactate synthase large subunit; 2 pyruvate = 2-acetolactate + CO2; High confidence in function and specificity.	0.913
korB	nifJ	PSM36_2331	PSM36_0571	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; High confidence in function and specificity.	Pyruvate dehydrogenase (NADP(+)); Pyruvate + CoA + NADP(+) <=> acetyl-CoA + CO(2) + NADPH; High confidence in function and specificity.	0.998
korB	vorA	PSM36_2331	PSM36_0714	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; High confidence in function and specificity.	Ketoisovalerate oxidoreductase subunit VorA; 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+; High confidence in function and specificity.	0.922
nifJ	PSM36_0964	PSM36_0571	PSM36_0964	Pyruvate dehydrogenase (NADP(+)); Pyruvate + CoA + NADP(+) <=> acetyl-CoA + CO(2) + NADPH; High confidence in function and specificity.	Indolepyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.	0.879
nifJ	acoA	PSM36_0571	PSM36_2448	Pyruvate dehydrogenase (NADP(+)); Pyruvate + CoA + NADP(+) <=> acetyl-CoA + CO(2) + NADPH; High confidence in function and specificity.	TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha [Energy production and conversion]; High confidence in function and specificity.	0.937
nifJ	ilvB	PSM36_0571	PSM36_0868	Pyruvate dehydrogenase (NADP(+)); Pyruvate + CoA + NADP(+) <=> acetyl-CoA + CO(2) + NADPH; High confidence in function and specificity.	Acetolactate synthase large subunit; 2 pyruvate = 2-acetolactate + CO2; High confidence in function and specificity.	0.966
nifJ	korB	PSM36_0571	PSM36_2331	Pyruvate dehydrogenase (NADP(+)); Pyruvate + CoA + NADP(+) <=> acetyl-CoA + CO(2) + NADPH; High confidence in function and specificity.	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; High confidence in function and specificity.	0.998
nifJ	vorA	PSM36_0571	PSM36_0714	Pyruvate dehydrogenase (NADP(+)); Pyruvate + CoA + NADP(+) <=> acetyl-CoA + CO(2) + NADPH; High confidence in function and specificity.	Ketoisovalerate oxidoreductase subunit VorA; 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+; High confidence in function and specificity.	0.998
vorA	acoA	PSM36_0714	PSM36_2448	Ketoisovalerate oxidoreductase subunit VorA; 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+; High confidence in function and specificity.	TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha [Energy production and conversion]; High confidence in function and specificity.	0.905
vorA	ilvB	PSM36_0714	PSM36_0868	Ketoisovalerate oxidoreductase subunit VorA; 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+; High confidence in function and specificity.	Acetolactate synthase large subunit; 2 pyruvate = 2-acetolactate + CO2; High confidence in function and specificity.	0.913

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