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apgM apgM pfkA1 pfkA1 PSM36_0279 PSM36_0279 ppdK ppdK pgk pgk nifJ nifJ pyk pyk fbaB fbaB vorB vorB vorA vorA pdhA pdhA pdhB pdhB PSM36_1042 PSM36_1042 PSM36_1043 PSM36_1043 PSM36_1161 PSM36_1161 PSM36_1295 PSM36_1295 PSM36_1318 PSM36_1318 PSM36_1521 PSM36_1521 PSM36_1535 PSM36_1535 GALM GALM fba fba PSM36_2015 PSM36_2015 pfkA3 pfkA3 PSM36_2183 PSM36_2183 korA korA korB korB tpiA tpiA PSM36_2445 PSM36_2445 acoC acoC PSM36_2447 PSM36_2447 acoA acoA eno eno pfp pfp pgi pgi acsA acsA gpmA gpmA pckA pckA PSM36_3467 PSM36_3467
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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apgMThis family represents 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (iPGAM), it is a metalloenzyme found particularly in archaea and some eubacteria. It is responsble for the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; High confidence in function and specificity. (401 aa)
pfkA16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (338 aa)
PSM36_0279Cinnamyl alcohol dehydrogenases (CAD), members of the medium chain dehydrogenase/reductase family, reduce cinnamaldehydes to cinnamyl alcohols in the last step of monolignal metabolism in plant cells walls. CAD binds 2 zinc ions and is NADPH-dependent. CAD family members are also found in non-plant species, e.g. in yeast where they have an aldehyde reductase activity. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins relat [...] (351 aa)
ppdKPyruvate, phosphate dikinase; ATP + pyruvate + phosphate <=> AMP + phosphoenolpyruvate + diphosphate; High confidence in function and specificity; Belongs to the PEP-utilizing enzyme family. (906 aa)
pgkPhosphoglycerate kinase; ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate; High confidence in function and specificity; Belongs to the phosphoglycerate kinase family. (419 aa)
nifJPyruvate dehydrogenase (NADP(+)); Pyruvate + CoA + NADP(+) <=> acetyl-CoA + CO(2) + NADPH; High confidence in function and specificity. (1194 aa)
pykATP + pyruvate = ADP + phosphoenolpyruvate; High confidence in function and specificity; Belongs to the pyruvate kinase family. (490 aa)
fbaBFructose-bisphosphate aldolase class 1; D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate; High confidence in function and specificity. (352 aa)
vorBKetoisovalerate oxidoreductase subunit VorB; 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin <=> S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced ferredoxin + H(+); High confidence in function and specificity. (360 aa)
vorAKetoisovalerate oxidoreductase subunit VorA; 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+; High confidence in function and specificity. (253 aa)
pdhAPyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (369 aa)
pdhBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3); High confidence in function and specificity. (325 aa)
PSM36_1042Branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; High confidence in function and specificity. (442 aa)
PSM36_1043Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]; High confidence in function and specificity. (277 aa)
PSM36_1161Galactose mutarotase_like; Converts alpha-aldose to the beta-anomer. (384 aa)
PSM36_1295This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]; High confidence in function and specificity. (321 aa)
PSM36_1318Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This family of MACS enzymes is found in archaea and bacteria. It is represented by the acyl-adenylating enzyme from Methanosarcina acetivorans (AAE_MA). AAE_MA is most active with propionate, butyrate, and the branched analogs: 2-methyl-propionate, butyrate, and pentanoate. The specific activity [...] (554 aa)
PSM36_1521Glyceraldehyde-3-phosphate dehydrogenase, cytosolic; D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH; High confidence in function and specificity; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
PSM36_1535This CD includes PGM2 and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes; High confidence in function and specificity. (583 aa)
GALMAldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (361 aa)
fbaFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; High confidence in function and specificity. (330 aa)
PSM36_2015Sugar kinase of the NBD/HSP70 family; High confidence in function and specificity. (319 aa)
pfkA36-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (327 aa)
PSM36_2183This model describes dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N-terminus contains a redox-active disulfide; High confidenc [...] (450 aa)
korA2-oxoglutarate oxidoreductase subunit KorA; Component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha-ketoglutarate, KG) to succinyl-CoA. Methyl viologen can act as electron acceptor in vitro; the physiologic electron acceptor is unknown. Is involved in the alternative TCA pathway that functions concurrently with fatty acid beta-oxidation. Since a growing body of evidence indicates that lipids (for example cholesterol and fatty acids) are a predominant growth substrate for M.tuberculosis during infection, flux through KOR l [...] (621 aa)
korB2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; High confidence in function and specificity. (349 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
PSM36_2445This model describes dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N-terminus contains a redox-active disulfide; High confidenc [...] (569 aa)
acoCDihydrolipoamide acetyltransferase; High confidence in function and specificity. (371 aa)
PSM36_2447Pyruvate dehydrogenase (acetyl-transferring); Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine <=> [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2); High confidence in function and specificity. (333 aa)
acoATPP-dependent pyruvate or acetoin dehydrogenase subunit alpha [Energy production and conversion]; High confidence in function and specificity. (330 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
pfpDiphosphate-fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (552 aa)
pgiGlucose-6-phosphate isomerase; D-glucose 6-phosphate = D-fructose 6-phosphate; High confidence in function and specificity; Belongs to the GPI family. (449 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (635 aa)
gpmA2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (530 aa)
PSM36_3467Sugar kinase; High confidence in function and specificity. (363 aa)
Your Current Organism:
Proteiniphilum saccharofermentans
NCBI taxonomy Id: 1642647
Other names: CECT 8610, DSM 28694, LMG 28299, LMG:28299, P. saccharofermentans, Proteiniphilum saccharofermentans Hahnke et al. 2016, Proteiniphilum sp. M3/6, strain M3/6
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