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| | fucI1 | L-fucose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose. (591 aa) |
| | PSM36_0067 | This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV. This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae; High confidence in function and specificity. (315 aa) |
| | PSM36_0071 | Hypothetical protein; High confidence in function and specificity. (195 aa) |
| | thrC | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine; High confidence in function and specificity. (433 aa) |
| | apgM | This family represents 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (iPGAM), it is a metalloenzyme found particularly in archaea and some eubacteria. It is responsble for the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; High confidence in function and specificity. (401 aa) |
| | thrA | Bifunctional aspartokinase; Aspartate kinase (AK) catalyzes the first reaction in the aspartate pathway; the phosphorylation of aspartate. The product of this reaction can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine; High confidence in function and specificity. (814 aa) |
| | PSM36_0186 | Oxidoreductase domain-containing protein; This group of enzymes utilise NADP or NAD, and is known as the GFO/IDH/MOCA family in UniProtKB/Swiss-Prot. GFO is a glucose-fructose oxidoreductase, which converts D-glucose and D-fructose into D-gluconolactone and D-glucitol in the sorbitol-gluconate pathway. MOCA is a rhizopine catabolism protein which may catalyse the NADH-dependent dehydrogenase reaction involved in rhizopine catabolism; High confidence in function and specificity. (423 aa) |
| | ydgJ | Putative oxidoreductase; This group of enzymes utilise NADP or NAD, and is known as the GFO/IDH/MOCA family in UniProtKB/Swiss-Prot. GFO is a glucose-fructose oxidoreductase, which converts D-glucose and D-fructose into D-gluconolactone and D-glucitol in the sorbitol-gluconate pathway. MOCA is a rhizopine catabolism protein which may catalyse the NADH-dependent dehydrogenase reaction involved in rhizopine catabolism. Other proteins belonging to this family include Gal80, a negative regulator for the expression of lactose and galactose metabolic genes; and several hypothetical proteins [...] (353 aa) |
| | pfkA1 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (338 aa) |
| | PSM36_0279 | Cinnamyl alcohol dehydrogenases (CAD), members of the medium chain dehydrogenase/reductase family, reduce cinnamaldehydes to cinnamyl alcohols in the last step of monolignal metabolism in plant cells walls. CAD binds 2 zinc ions and is NADPH-dependent. CAD family members are also found in non-plant species, e.g. in yeast where they have an aldehyde reductase activity. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins relat [...] (351 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (333 aa) |
| | PSM36_0317 | Putative membrane protein; Family membership. (171 aa) |
| | PSM36_0361 | nanoRNase/pAp phosphatase, hydrolyzes c-di-AMP and oligoRNAs [Nucleotide transport and metabolism]; High confidence in function and specificity. (333 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; D-ribulose 5-phosphate = D-xylulose 5-phosphate; High confidence in function and specificity; Belongs to the ribulose-phosphate 3-epimerase family. (216 aa) |
| | ppdK | Pyruvate, phosphate dikinase; ATP + pyruvate + phosphate <=> AMP + phosphoenolpyruvate + diphosphate; High confidence in function and specificity; Belongs to the PEP-utilizing enzyme family. (906 aa) |
| | PSM36_0474 | Putative D-isomer specific 2-hydroxyacid dehydrogenases; 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrange [...] (298 aa) |
| | pgk | Phosphoglycerate kinase; ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate; High confidence in function and specificity; Belongs to the phosphoglycerate kinase family. (419 aa) |
| | nifJ | Pyruvate dehydrogenase (NADP(+)); Pyruvate + CoA + NADP(+) <=> acetyl-CoA + CO(2) + NADPH; High confidence in function and specificity. (1194 aa) |
| | pyk | ATP + pyruvate = ADP + phosphoenolpyruvate; High confidence in function and specificity; Belongs to the pyruvate kinase family. (490 aa) |
| | PSM36_0586 | Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants; Conser [...] (443 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (385 aa) |
| | PSM36_0621 | Putative D-3-Phosphoglycerate Dehydrogenases; Phosphoglycerate dehydrogenases (PGDHs) catalyze the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDHs come in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily, which also include groups such as L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase; High confidence in function and specificity. (309 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (359 aa) |
| | gdh | NAD-specific glutamate dehydrogenase; High confidence in function and specificity; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa) |
| | fbaB | Fructose-bisphosphate aldolase class 1; D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate; High confidence in function and specificity. (352 aa) |
| | sucD | Succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (288 aa) |
| | sucC | Succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (376 aa) |
| | PSM36_0697 | Phosphoserine phosphatase; The ACT_PSP_2 CD includes the second of the two ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB). PSPs belong to the L-2-haloacid dehalogenase-like protein superfamily. PSP is involved in serine metabolism; serine is synthesized from phosphoglycerate through sequential reactions catalyzed by 3-phosphoglycerate dehydrogenase (SerA), 3-phosphoserine aminotransferase (SerC), and SerB. Members of this CD belong to the superfamily of ACT regulatory domains, Links, ?; High confidence in function and specificity. (410 aa) |
| | PSM36_0706 | The enzyme activities methylenetetrahydrofolate reductase and 5,10-methylenetetrahydrofolate reductase (FADH) differ in that 1.5.1.20 (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while 1.7.99.5 (assigned in many bacteria) is flexible with respect to the acceptor; both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as 1.5.1.20 and 1.7.99.5, this model describes the subset of proteins found in bacteria, and currently designated 1.7.99.5. This protein is an FAD-containing flavoprotein. [Amino acid biosynt [...] (316 aa) |
| | PSM36_0711 | 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Hypothetical protein. (76 aa) |
| | vorB | Ketoisovalerate oxidoreductase subunit VorB; 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin <=> S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced ferredoxin + H(+); High confidence in function and specificity. (360 aa) |
| | vorA | Ketoisovalerate oxidoreductase subunit VorA; 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+; High confidence in function and specificity. (253 aa) |
| | PSM36_0715 | This family includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein. It is not known whether the gamma subunit has a catalytic or regulatory role. Pyruvate oxidoreductase (POR) catalyses the final step in the fermentation of carbohydrates in anaerobic microorganisms. This involves the oxidative decarboxylation of pyruvate with the participation of thiamine followed by the transfer of an acetyl moiety to coenzyme A for the synthesis of acetyl-CoA. The family also includes pyruvate flavodoxin oxidore [...] (184 aa) |
| | PSM36_0735 | NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs; Hig [...] (199 aa) |
| | PSM36_0747 | Putative conserved protein YurZ; High confidence in function and specificity. (238 aa) |
| | pdxH | Pyridoxine/pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (206 aa) |
| | PSM36_0887 | Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate; High confidence in function and specificity. (750 aa) |
| | icd | Isocitrate dehydrogenase [NADP]; Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH; High confidence in function and specificity. (419 aa) |
| | PSM36_0889 | Citrate synthaseis a member of a small family of enzymes that can directly form a carbon-carbon bond without the presence of metal ion cofactors. It catalyses the first reaction in the Krebs' cycle, namely the conversion of oxaloacetate and acetyl-coenzyme A into citrate and coenzyme A. This reaction is important for energy generation and for carbon assimilation; High confidence in function and specificity. (451 aa) |
| | PSM36_0890 | Isocitrate dehydrogenase [NADP], chloroplastic; Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH; High confidence in function and specificity; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (413 aa) |
| | ulaF | L-ribulose-5-phosphate 4-epimerase UlaF; Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization; High confidence in function and specificity. (229 aa) |
| | PSM36_0958 | Pyruvate carboxylase subunit B; High confidence in function and specificity. (639 aa) |
| | PSM36_0959 | Na+-transporting oxaloacetate decarboxylase beta subunit; Members of this family are integral membrane proteins. The decarboxylation reactions they catalyse are coupled to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis; High confidence in function and specificity. (402 aa) |
| | PSM36_0962 | Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (436 aa) |
| | folD | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (304 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (369 aa) |
| | pdhB | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3); High confidence in function and specificity. (325 aa) |
| | PSM36_1042 | Branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; High confidence in function and specificity. (442 aa) |
| | PSM36_1043 | Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]; High confidence in function and specificity. (277 aa) |
| | PSM36_1070 | Predicted dehydrogenase [General function prediction only]; High confidence in function and specificity. (454 aa) |
| | PSM36_1073 | Glycerate-2-kinase; High confidence in function and specificity. (450 aa) |
| | PSM36_1161 | Galactose mutarotase_like; Converts alpha-aldose to the beta-anomer. (384 aa) |
| | PSM36_1170 | Transketolase; This model is designed to capture orthologs of bacterial transketolases. The group includes two from the yeast Saccharomyces cerevisiae but excludes dihydroxyactetone synthases (formaldehyde transketolases) from various yeasts and the even more distant mammalian transketolases. Among the family of thiamine diphosphate-dependent enzymes that includes transketolases, dihydroxyacetone synthases, pyruvate dehydrogenase E1-beta subunits, and deoxyxylulose-5-phosphate synthases, mammalian and bacterial transketolases seem not to be orthologous. [Energy metabolism, Pentose phos [...] (675 aa) |
| | PSM36_1171 | Ribose-5-phosphate isomerase B; D-ribose 5-phosphate <=> D-ribulose 5-phosphate; High confidence in function and specificity. (151 aa) |
| | PSM36_1243 | Oxidoreductase domain protein; This group of enzymes utilise NADP or NAD, and is known as the GFO/IDH/MOCA family in UniProtKB/Swiss-Prot. GFO is a glucose-fructose oxidoreductase, which converts D-glucose and D-fructose into D-gluconolactone and D-glucitol in the sorbitol-gluconate pathway. MOCA is a rhizopine catabolism protein which may catalyse the NADH-dependent dehydrogenase reaction involved in rhizopine catabolism; High confidence in function and specificity. (326 aa) |
| | fhs | Formate-tetrahydrofolate ligase; ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. (554 aa) |
| | PSM36_1295 | This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]; High confidence in function and specificity. (321 aa) |
| | PSM36_1308 | methylmalonyl-CoA mutase; The adenosylcobalamin-binding, catalytic chain of methylmalonyl-CoA mutase may form homodimers, as in mitochondrion and E. coli, or heterodimers with a shorter, homologous chain that does not bind adenosylcobalamin. This model describes this non-catalytic beta chain, as found in the enzyme from Propionibacterium freudenreichii, for which the 3-dimensional structure has been solved. [Central intermediary metabolism, Other]; High confidence in function and specificity. (632 aa) |
| | mutB | Methylmalonyl-CoA mutase large subunit; Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates; High confidence in function and specificity. (715 aa) |
| | PSM36_1318 | Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This family of MACS enzymes is found in archaea and bacteria. It is represented by the acyl-adenylating enzyme from Methanosarcina acetivorans (AAE_MA). AAE_MA is most active with propionate, butyrate, and the branched analogs: 2-methyl-propionate, butyrate, and pentanoate. The specific activity [...] (554 aa) |
| | PSM36_1434 | Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second; High confidence in function and specificity. (647 aa) |
| | PSM36_1521 | Glyceraldehyde-3-phosphate dehydrogenase, cytosolic; D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH; High confidence in function and specificity; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | mgsA | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (152 aa) |
| | PSM36_1535 | This CD includes PGM2 and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes; High confidence in function and specificity. (583 aa) |
| | GALM | Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (361 aa) |
| | PSM36_1671 | Putative membrane protein. (159 aa) |
| | PSM36_1786 | NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs; Hig [...] (210 aa) |
| | PSM36_1787 | Catechol-2,3-dioxygenase [Secondary metabolites biosynthesis, transport and catabolism]; Conserved hypothetical protein. (282 aa) |
| | PSM36_1818 | Propionyl-CoA carboxylase beta chain, mitochondrial; ATP + propanoyl-CoA + HCO3-= ADP + phosphate + (S)-methylmalonyl-CoA; High confidence in function and specificity. (510 aa) |
| | PSM36_1820 | Acetyl/propionyl-CoA carboxylase, alpha subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (502 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate; High confidence in function and specificity. (311 aa) |
| | fba | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; High confidence in function and specificity. (330 aa) |
| | sudA | Putative oxidoreductase; Provisional; High confidence in function and specificity. (492 aa) |
| | PSM36_1936 | Cysteine synthase; O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate; High confidence in function and specificity. (315 aa) |
| | pflB | Acetyl-CoA + formate = CoA + pyruvate; High confidence in function and specificity. (746 aa) |
| | PSM36_1992 | Putative D-isomer specific 2-hydroxyacid dehydrogenases; 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrange [...] (318 aa) |
| | PSM36_2015 | Sugar kinase of the NBD/HSP70 family; High confidence in function and specificity. (319 aa) |
| | PSM36_2049 | Lactonase; This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase and muconate cycloisomerase, which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold; High confidence in function and specificity. (394 aa) |
| | pfkA3 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (327 aa) |
| | PSM36_2140 | MMCE, also called methylmalonyl-CoA racemase interconverts (2R)-methylmalonyl-CoA and (2S)-methylmalonyl-CoA. MMCE has been found in bacteria, archaea, and in animals. In eukaryotes, MMCE is an essential enzyme in a pathway that converts propionyl-CoA to succinyl-CoA, and is important in the breakdown of odd-chain length fatty acids, branched-chain amino acids, and other metabolites. In bacteria, MMCE participates in the reverse pathway for propionate fermentation, glyoxylate regeneration, and the biosynthesis of polyketide antibiotics. MMCE is closely related to glyoxalase I and type [...] (135 aa) |
| | PSM36_2143 | Pyruvate carboxylase subunit B. (145 aa) |
| | PSM36_2144 | Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; High confidence in function and specificity. (385 aa) |
| | gcdB | Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase; Members of this family are integral membrane proteins. The decarboxylation reactions they catalyse are coupled to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis; High confidence in function and specificity. (385 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (318 aa) |
| | PSM36_2177 | This family includes class II aldolases and adducins which have not been ascribed any enzymatic function; High confidence in function and specificity. (424 aa) |
| | PSM36_2183 | This model describes dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N-terminus contains a redox-active disulfide; High confidenc [...] (450 aa) |
| | rhaB | Rhamnulokinase; Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate; High confidence in function and specificity. (494 aa) |
| | rhaA | L-rhamnose isomerase; L-rhamnopyranose = L-rhamnulose; High confidence in function and specificity; Belongs to the rhamnose isomerase family. (421 aa) |
| | PSM36_2323 | Sugar phosphate isomerase/epimerase [Carbohydrate transport and metabolism]; High confidence in function and specificity. (276 aa) |
| | korA | 2-oxoglutarate oxidoreductase subunit KorA; Component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha-ketoglutarate, KG) to succinyl-CoA. Methyl viologen can act as electron acceptor in vitro; the physiologic electron acceptor is unknown. Is involved in the alternative TCA pathway that functions concurrently with fatty acid beta-oxidation. Since a growing body of evidence indicates that lipids (for example cholesterol and fatty acids) are a predominant growth substrate for M.tuberculosis during infection, flux through KOR l [...] (621 aa) |
| | korB | 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; High confidence in function and specificity. (349 aa) |
| | maeB | Bifunctional malic enzyme oxidoreductase/phosphotransacetylase; (S)-malate + NADP(+) <=> pyruvate + CO(2) + NADPH, Oxaloacetate <=> pyruvate + CO(2); High confidence in function and specificity. (767 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | acn | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (925 aa) |
| | PSM36_2445 | This model describes dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N-terminus contains a redox-active disulfide; High confidenc [...] (569 aa) |
| | acoC | Dihydrolipoamide acetyltransferase; High confidence in function and specificity. (371 aa) |
| | PSM36_2447 | Pyruvate dehydrogenase (acetyl-transferring); Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine <=> [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2); High confidence in function and specificity. (333 aa) |
| | acoA | TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha [Energy production and conversion]; High confidence in function and specificity. (330 aa) |
| | PSM36_2451 | Nitric oxide reductase large subunit; High confidence in function and specificity. (741 aa) |
| | mdh | (S)-malate + NAD(+) <=> oxaloacetate + NADH; High confidence in function and specificity; Belongs to the LDH/MDH superfamily. (332 aa) |
| | dapB | Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; High confidence in function and specificity; Belongs to the DapB family. (241 aa) |
| | gltX | Glutamate-tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (505 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa) |
| | PSM36_2667 | Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in the human uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria, a recessive inborn error of metabolism also known as Gunther disease; High confidence in function and specificity. (254 aa) |
| | PSM36_2719 | This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV. This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae; High confidence in function and specificity. (311 aa) |
| | PSM36_2725 | Haloacid dehalogenase-like hydrolase; High confidence in function and specificity. (201 aa) |
| | argD | Acetylornithine aminotransferase; N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate; High confidence in function and specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (374 aa) |
| | pta | Acetyl-CoA + phosphate = CoA + acetyl phosphate; High confidence in function and specificity. (337 aa) |
| | PSM36_2749 | 3-hydroxyacyl-CoA dehydrogenase; S)-3-hydroxybutanoyl-CoA + NADP(+) <=> 3-acetoacetyl-CoA + NADPH; High confidence in function and specificity. (325 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (509 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (242 aa) |
| | PSM36_2770 | Phenylacetate-CoA ligase; PaaK catalyzes the first step in the aromatic degradation pathway, by converting phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Phenylacetate-CoA ligase has been found in proteobacteria as well as gram positive prokaryotes. The enzyme is specifically induced after aerobic growth in a chemically defined medium containing PA or phenylalanine (Phe) as the sole carbon source. PaaKs are members of the adenylate-forming enzyme (AFE) family. However, sequence comparison reveals divergent features of PaaK with respect to the superfamily, including a novel N-te [...] (431 aa) |
| | PSM36_2809 | L-threonine aldolase; High confidence in function and specificity. (341 aa) |
| | ssdA | Succinate-semialdehyde dehydrogenase [NADP(+)]; High confidence in function and specificity. (477 aa) |
| | PSM36_2865 | Cytochrome c nitrite reductase; Members of this protein family are NrfH, a tetraheme cytochrome c. NrfH is the cytochrome c nitrite reductase small subunit, and forms a heterodimer with NrfA, the catalytic subunit. While NrfA can act as a monomer, NrfH can bind to and anchor NrfA in the membrane and enables electron transfer to NrfA from quinones. [Energy metabolism, Electron transport]; High confidence in function and specificity. (198 aa) |
| | nrfA | Formate-dependent nitrite reductase; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (498 aa) |
| | glnA | Glutamine synthetase; ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine; High confidence in function and specificity; Belongs to the glutamine synthetase family. (731 aa) |
| | gltB | 2 L-glutamate + NADP(+) <=> L-glutamine + 2-oxoglutarate + NADPH; High confidence in function and specificity. (1510 aa) |
| | gltD | Glutamate synthase subunit beta; This model represents one of three built for the NADPH-dependent or NADH-dependent glutamate synthase and 1.4.1.14, respectively) small subunit or homologous region. TIGR01316 describes a family in several archaeal and deeply branched bacterial lineages of a homotetrameric form for which there is no large subunit. Another model describes glutamate synthase small subunit from gamma and some alpha subdivision Proteobacteria plus paralogs of unknown function. This model describes the small subunit, or homologous region of longer forms proteins, of eukaryot [...] (490 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | PSM36_2950 | Putative serine O-acetyltransferase; Serine acetyltransferase [Amino acid transport and metabolism]; High confidence in function and specificity. (273 aa) |
| | PSM36_2994 | Dihydrolipoamide succinyltransferase; Succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine <=> CoA + enzyme N(6)-(S-succinyldihydrolipoyl)lysine; High confidence in function and specificity. (449 aa) |
| | odhA | 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; High confidence in function and specificity. (907 aa) |
| | pfp | Diphosphate-fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (552 aa) |
| | dapA | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa) |
| | pgi | Glucose-6-phosphate isomerase; D-glucose 6-phosphate = D-fructose 6-phosphate; High confidence in function and specificity; Belongs to the GPI family. (449 aa) |
| | PSM36_3071 | Putative membrane protein. (169 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (635 aa) |
| | fumA | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (546 aa) |
| | fumC | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa) |
| | PSM36_3199 | Sugar lactone lactonase YvrE; High confidence in function and specificity. (293 aa) |
| | PSM36_3217 | Putative membrane protein. (162 aa) |
| | PSM36_3246 | This family consists of the succinate dehydrogenase subunit C of Bacillus subtilis, designated cytochrome b-558, and related sequences that include a fumarate reductase subunit C. This subfamily is only weakly; High confidence in function and specificity. (224 aa) |
| | sdhA | Succinate dehydrogenase flavoprotein subunit; Succinate + a quinone <=> fumarate + a quinol; High confidence in function and specificity. (647 aa) |
| | PSM36_3248 | Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Succinate + a quinone <=> fumarate + a quinol; High confidence in function and specificity. (251 aa) |
| | PSM36_3285 | Aspartate kinase; High confidence in function and specificity. (459 aa) |
| | fucI3 | L-fucose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose. (589 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (530 aa) |
| | gnd | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (484 aa) |
| | PSM36_3418 | 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources; High confidence in function and specificity. (359 aa) |
| | PSM36_3439 | 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources; High confidence in function and specificity. (345 aa) |
| | PSM36_3440 | Keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; High confidence in function and specificity. (259 aa) |
| | PSM36_3467 | Sugar kinase; High confidence in function and specificity. (363 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | gdhA | L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H; High confidence in function and specificity; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (444 aa) |
