(34 nodes) Mixed, incl. Deoxyribonucleotide metabolic process, and Riboflavin metabolic process network (Phytophthora ramorum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3G5F5_PHYRM	Uncharacterized protein. (336 aa)
	H3G6R7_PHYRM	Pterin-binding domain-containing protein. (437 aa)
	H3G722_PHYRM	CMP/dCMP-type deaminase domain-containing protein. (165 aa)
	H3G797_PHYRM	GTP_cyclohydroI domain-containing protein. (203 aa)
	H3G7K6_PHYRM	Uncharacterized protein. (308 aa)
	H3G8T6_PHYRM	Uncharacterized protein. (357 aa)
	H3G8T7_PHYRM	Uncharacterized protein. (364 aa)
	H3G8V0_PHYRM	Nucleoside diphosphate kinase. (151 aa)
	H3G8X8_PHYRM	Uncharacterized protein. (345 aa)
	H3G978_PHYRM	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (580 aa)
	H3G9R6_PHYRM	Thymidylate_kin domain-containing protein. (199 aa)
	H3G9Z9_PHYRM	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (190 aa)
	H3GA16_PHYRM	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (789 aa)
	H3GA88_PHYRM	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (198 aa)
	H3GAQ6_PHYRM	Pyruvate kinase; Belongs to the pyruvate kinase family. (488 aa)
	H3GAQ9_PHYRM	Pyruvate kinase; Belongs to the pyruvate kinase family. (503 aa)
	H3GC59_PHYRM	Uncharacterized protein. (244 aa)
	H3GE58_PHYRM	Thymidine kinase. (173 aa)
	H3GEE0_PHYRM	Coronin; Belongs to the WD repeat coronin family. (465 aa)
	H3GHG7_PHYRM	Mur_ligase_M domain-containing protein. (564 aa)
	H3GIE5_PHYRM	GTP_cyclohydro2 domain-containing protein. (281 aa)
	H3GJY6_PHYRM	Coronin; Belongs to the WD repeat coronin family. (1000 aa)
	H3GLE7_PHYRM	Folate gamma-glutamyl hydrolase. (318 aa)
	H3GLW9_PHYRM	Uncharacterized protein. (516 aa)
	H3GNB4_PHYRM	DM10 domain-containing protein. (349 aa)
	H3GVR3_PHYRM	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (579 aa)
	H3GWN7_PHYRM	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. (493 aa)
	H3GXD8_PHYRM	Uncharacterized protein. (464 aa)
	H3GXU6_PHYRM	Mur_ligase_M domain-containing protein. (563 aa)
	H3H0R2_PHYRM	dUTPase domain-containing protein. (277 aa)
	H3H5S3_PHYRM	6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (215 aa)
	H3H7V5_PHYRM	CMP/dCMP-type deaminase domain-containing protein. (148 aa)
	H3HB71_PHYRM	Uncharacterized protein. (685 aa)
	H3HCR6_PHYRM	Nucleoside diphosphate kinase. (216 aa)

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3G5F5_PHYRM	H3G8V0_PHYRM	H3G5F5	H3G8V0	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.657
H3G5F5_PHYRM	H3G9R6_PHYRM	H3G5F5	H3G9R6	Uncharacterized protein.	Thymidylate_kin domain-containing protein.	0.676
H3G5F5_PHYRM	H3GA16_PHYRM	H3G5F5	H3GA16	Uncharacterized protein.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.985
H3G5F5_PHYRM	H3GE58_PHYRM	H3G5F5	H3GE58	Uncharacterized protein.	Thymidine kinase.	0.553
H3G5F5_PHYRM	H3GNB4_PHYRM	H3G5F5	H3GNB4	Uncharacterized protein.	DM10 domain-containing protein.	0.517
H3G5F5_PHYRM	H3GVR3_PHYRM	H3G5F5	H3GVR3	Uncharacterized protein.	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family.	0.549
H3G5F5_PHYRM	H3GWN7_PHYRM	H3G5F5	H3GWN7	Uncharacterized protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.681
H3G5F5_PHYRM	H3H0R2_PHYRM	H3G5F5	H3H0R2	Uncharacterized protein.	dUTPase domain-containing protein.	0.628
H3G5F5_PHYRM	H3HB71_PHYRM	H3G5F5	H3HB71	Uncharacterized protein.	Uncharacterized protein.	0.566
H3G5F5_PHYRM	H3HCR6_PHYRM	H3G5F5	H3HCR6	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.657
H3G6R7_PHYRM	H3G797_PHYRM	H3G6R7	H3G797	Pterin-binding domain-containing protein.	GTP_cyclohydroI domain-containing protein.	0.974
H3G6R7_PHYRM	H3G978_PHYRM	H3G6R7	H3G978	Pterin-binding domain-containing protein.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.431
H3G6R7_PHYRM	H3G9R6_PHYRM	H3G6R7	H3G9R6	Pterin-binding domain-containing protein.	Thymidylate_kin domain-containing protein.	0.739
H3G6R7_PHYRM	H3G9Z9_PHYRM	H3G6R7	H3G9Z9	Pterin-binding domain-containing protein.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.734
H3G6R7_PHYRM	H3GE58_PHYRM	H3G6R7	H3GE58	Pterin-binding domain-containing protein.	Thymidine kinase.	0.609
H3G6R7_PHYRM	H3GEE0_PHYRM	H3G6R7	H3GEE0	Pterin-binding domain-containing protein.	Coronin; Belongs to the WD repeat coronin family.	0.424
H3G6R7_PHYRM	H3GHG7_PHYRM	H3G6R7	H3GHG7	Pterin-binding domain-containing protein.	Mur_ligase_M domain-containing protein.	0.996
H3G6R7_PHYRM	H3GJY6_PHYRM	H3G6R7	H3GJY6	Pterin-binding domain-containing protein.	Coronin; Belongs to the WD repeat coronin family.	0.424
H3G6R7_PHYRM	H3GWN7_PHYRM	H3G6R7	H3GWN7	Pterin-binding domain-containing protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.937
H3G6R7_PHYRM	H3GXU6_PHYRM	H3G6R7	H3GXU6	Pterin-binding domain-containing protein.	Mur_ligase_M domain-containing protein.	0.996

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