(127 nodes) Nucleic acid phosphodiester bond hydrolysis network (Phytophthora ramorum)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3G596_PHYRM	Uncharacterized protein. (248 aa)
	H3G592_PHYRM	RNB domain-containing protein. (187 aa)
	H3G590_PHYRM	S1 motif domain-containing protein. (703 aa)
	H3G527_PHYRM	Piwi domain-containing protein. (127 aa)
	NTH1	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (246 aa)
	H3H8K4_PHYRM	Uncharacterized protein. (208 aa)
	H3H843_PHYRM	RNB domain-containing protein. (735 aa)
	H3H7K0_PHYRM	3'-5' exonuclease domain-containing protein. (278 aa)
	H3H7I2_PHYRM	PAZ domain-containing protein. (270 aa)
	H3H6J9_PHYRM	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (689 aa)
	H3H6I3_PHYRM	Uncharacterized protein. (132 aa)
	H3H5N9_PHYRM	Uncharacterized protein. (408 aa)
	H3H432_PHYRM	Uncharacterized protein. (209 aa)
	H3H3X4_PHYRM	Exonuclease domain-containing protein. (508 aa)
	H3H3R9_PHYRM	Uncharacterized protein. (379 aa)
	H3H3C2_PHYRM	Endo/exonuclease/phosphatase domain-containing protein. (464 aa)
	H3H3B0_PHYRM	Endo/exonuclease/phosphatase domain-containing protein. (299 aa)
	H3H3A9_PHYRM	Endo/exonuclease/phosphatase domain-containing protein. (328 aa)
	H3H373_PHYRM	Endo/exonuclease/phosphatase domain-containing protein. (364 aa)
	H3H2U8_PHYRM	Uncharacterized protein. (1327 aa)
	H3H2D0_PHYRM	Uncharacterized protein. (531 aa)
	H3H1D5_PHYRM	Uncharacterized protein. (222 aa)
	H3H137_PHYRM	Uncharacterized protein. (106 aa)
	H3GZX6_PHYRM	Cleavage and polyadenylation specificity factor subunit 2. (731 aa)
	H3GZT5_PHYRM	Endo/exonuclease/phosphatase domain-containing protein. (318 aa)
	H3GZJ8_PHYRM	Exonuclease domain-containing protein. (929 aa)
	H3GZH3_PHYRM	Uncharacterized protein. (472 aa)
	H3GZE2_PHYRM	ERCC4 domain-containing protein. (567 aa)
	H3GZ71_PHYRM	RNB domain-containing protein. (507 aa)
	H3GYD8_PHYRM	Kri1_C domain-containing protein. (685 aa)
	H3GXW6_PHYRM	Uncharacterized protein. (1049 aa)
	H3GL41_PHYRM	Uncharacterized protein. (242 aa)
	TatD3	TatD related DNase. (1098 aa)
	H3GKK1_PHYRM	Uncharacterized protein. (427 aa)
	H3GJZ2_PHYRM	Uncharacterized protein. (895 aa)
	H3GJZ0_PHYRM	Uncharacterized protein; Belongs to the argonaute family. (1137 aa)
	H3GJX3_PHYRM	Uncharacterized protein. (982 aa)
	H3GL78_PHYRM	RAI1 domain-containing protein. (331 aa)
	H3GX87_PHYRM	Uncharacterized protein. (282 aa)
	H3GWY3_PHYRM	Uncharacterized protein. (359 aa)
	H3GW95_PHYRM	Endo/exonuclease/phosphatase domain-containing protein. (199 aa)
	H3GW85_PHYRM	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (299 aa)
	H3GVE7_PHYRM	TNase-like domain-containing protein. (250 aa)
	H3GUX1_PHYRM	Uncharacterized protein. (586 aa)
	H3GUH6_PHYRM	RNB domain-containing protein; Belongs to the RNR ribonuclease family. (1089 aa)
	H3GUC2_PHYRM	CID domain-containing protein. (593 aa)
	H3GTR2_PHYRM	Bms1-type G domain-containing protein. (1195 aa)
	H3GTI0_PHYRM	PX domain-containing protein. (808 aa)
	H3GI12_PHYRM	Uncharacterized protein. (248 aa)
	H3GHZ0_PHYRM	Mut7-C domain-containing protein. (170 aa)
	H3GHY9_PHYRM	Uncharacterized protein. (279 aa)
	H3GHP9_PHYRM	CLP1_P domain-containing protein. (630 aa)
	H3GHE4_PHYRM	WD_REPEATS_REGION domain-containing protein. (920 aa)
	H3GH19_PHYRM	Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (128 aa)
	H3GGX3_PHYRM	DBR1 domain-containing protein. (829 aa)
	H3GGQ2_PHYRM	Fibronectin type-III domain-containing protein. (601 aa)
	H3GG85_PHYRM	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
	H3GG59_PHYRM	Uncharacterized protein. (224 aa)
	H3GG34_PHYRM	Uncharacterized protein. (1570 aa)
	H3GTA4_PHYRM	Endo/exonuclease/phosphatase domain-containing protein. (578 aa)
	H3GG27_PHYRM	Uncharacterized protein. (262 aa)
	H3GFP6_PHYRM	mRNA_decap_C domain-containing protein. (319 aa)
	NTH1-2	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (308 aa)
	H3GFB9_PHYRM	PAZ domain-containing protein. (270 aa)
	H3GF99_PHYRM	Piwi domain-containing protein. (460 aa)
	H3GED9_PHYRM	Uncharacterized protein. (229 aa)
	H3GED1_PHYRM	Uncharacterized protein. (332 aa)
	H3GE15_PHYRM	XPA_C domain-containing protein. (204 aa)
	H3GCB3_PHYRM	Uncharacterized protein. (295 aa)
	H3GC58_PHYRM	Uncharacterized protein; Belongs to the RNase T2 family. (312 aa)
	H3GC32_PHYRM	Uncharacterized protein. (496 aa)
	H3GBM2_PHYRM	Lactamase_B domain-containing protein. (297 aa)
	H3GB12_PHYRM	Uncharacterized protein. (267 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (392 aa)
	H3GAM4_PHYRM	DNA polymerase. (1157 aa)
	H3GA74_PHYRM	AAA_23 domain-containing protein. (221 aa)
	H3G9T8_PHYRM	S1 domain-containing protein. (290 aa)
	H3G9I1_PHYRM	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (105 aa)
	TatD4	TatD related DNase. (239 aa)
	TatD1	TatD related DNase. (307 aa)
	H3G8Z9_PHYRM	Piwi domain-containing protein. (208 aa)
	H3G8R9_PHYRM	Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (406 aa)
	H3G8J4_PHYRM	Uncharacterized protein. (208 aa)
	H3G8C6_PHYRM	Helicase ATP-binding domain-containing protein. (781 aa)
	H3G835_PHYRM	Uncharacterized protein. (673 aa)
	H3G820_PHYRM	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (239 aa)
	H3G819_PHYRM	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (270 aa)
	H3G7Z9_PHYRM	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (199 aa)
	H3G7C4_PHYRM	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2185 aa)
	H3G786_PHYRM	Uncharacterized protein. (242 aa)
	H3GSI3_PHYRM	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (1001 aa)
	H3GSG9_PHYRM	Uncharacterized protein. (402 aa)
	H3GS59_PHYRM	Uncharacterized protein. (1057 aa)
	H3GS09_PHYRM	Uncharacterized protein. (366 aa)
	H3GRW7_PHYRM	Mrr_cat domain-containing protein. (162 aa)
	H3G6N5_PHYRM	Uncharacterized protein. (535 aa)
	H3G5W3_PHYRM	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. (490 aa)
	H3GRJ3_PHYRM	Uncharacterized protein. (654 aa)
	H3GR32_PHYRM	Uncharacterized protein; Belongs to the RNase T2 family. (345 aa)
	H3GR05_PHYRM	Uncharacterized protein. (221 aa)
	H3GPY8_PHYRM	Uncharacterized protein. (258 aa)
	H3GNX7_PHYRM	Uncharacterized protein; Belongs to the RNase T2 family. (246 aa)
	H3GNQ3_PHYRM	Bms1-type G domain-containing protein. (833 aa)
	H3GNK9_PHYRM	Uncharacterized protein. (168 aa)
	H3GND3_PHYRM	Uncharacterized protein. (1612 aa)
	H3GMZ6_PHYRM	Uncharacterized protein. (625 aa)
	TatD2	TatD related DNase. (303 aa)
	H3GM84_PHYRM	POLIIIAc domain-containing protein. (401 aa)
	H3GLL2_PHYRM	Uncharacterized protein. (1070 aa)
	H3GLK3_PHYRM	MoCF_biosynth domain-containing protein. (1405 aa)
	H3G6X5_PHYRM	Uncharacterized protein. (352 aa)
	H3GLG9_PHYRM	Uncharacterized protein. (828 aa)
	H3HE99_PHYRM	Uncharacterized protein. (407 aa)
	H3HDJ6_PHYRM	Helicase ATP-binding domain-containing protein. (520 aa)
	H3HD70_PHYRM	Lactamase_B domain-containing protein. (854 aa)
	H3HD09_PHYRM	RNase_Zc3h12a domain-containing protein. (311 aa)
	H3HCX7_PHYRM	Uncharacterized protein. (1249 aa)
	H3HCP8_PHYRM	Uncharacterized protein. (300 aa)
	H3HCL6_PHYRM	Uncharacterized protein; Belongs to the argonaute family. (1039 aa)
	H3HBX2_PHYRM	Uncharacterized protein. (1471 aa)
	H3HBU6_PHYRM	Uncharacterized protein. (1854 aa)
	H3HBI4_PHYRM	Exonuclease domain-containing protein. (343 aa)
	H3HBA3_PHYRM	RNB domain-containing protein; Belongs to the RNR ribonuclease family. (1186 aa)
	H3HB56_PHYRM	Uncharacterized protein. (602 aa)
	H3HAX1_PHYRM	Uncharacterized protein. (189 aa)
	H3HAS6_PHYRM	Uncharacterized protein; Belongs to the RNase T2 family. (360 aa)
	H3HA42_PHYRM	HRDC domain-containing protein. (723 aa)

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	H3G5W3_PHYRM	H3GAS1	H3G5W3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family.	0.980
FEN1	H3G6N5_PHYRM	H3GAS1	H3G6N5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.867
FEN1	H3G6X5_PHYRM	H3GAS1	H3G6X5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.898
FEN1	H3G7C4_PHYRM	H3GAS1	H3G7C4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.850
FEN1	H3G7Z9_PHYRM	H3GAS1	H3G7Z9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.613
FEN1	H3G819_PHYRM	H3GAS1	H3G819	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	0.739
FEN1	H3G820_PHYRM	H3GAS1	H3G820	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	0.739
FEN1	H3G8C6_PHYRM	H3GAS1	H3G8C6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Helicase ATP-binding domain-containing protein.	0.750
FEN1	H3G9I1_PHYRM	H3GAS1	H3G9I1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.503
FEN1	H3GA74_PHYRM	H3GAS1	H3GA74	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA_23 domain-containing protein.	0.908
FEN1	H3GAM4_PHYRM	H3GAS1	H3GAM4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.990
FEN1	H3GC32_PHYRM	H3GAS1	H3GC32	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.550
FEN1	H3GE15_PHYRM	H3GAS1	H3GE15	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	XPA_C domain-containing protein.	0.734
FEN1	H3GED1_PHYRM	H3GAS1	H3GED1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.954
FEN1	H3GG27_PHYRM	H3GAS1	H3GG27	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.763
FEN1	H3GG34_PHYRM	H3GAS1	H3GG34	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.790
FEN1	H3GG85_PHYRM	H3GAS1	H3GG85	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.485
FEN1	H3GLL2_PHYRM	H3GAS1	H3GLL2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.545
FEN1	H3GMZ6_PHYRM	H3GAS1	H3GMZ6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.534
FEN1	H3GNK9_PHYRM	H3GAS1	H3GNK9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.534

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