(73 nodes) Metabolism of nucleotides network (Phytophthora ramorum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	H3G8S4_PHYRM	Glutaredoxin domain-containing protein. (104 aa)
	H3GLW9_PHYRM	Uncharacterized protein. (516 aa)
	H3GNW5_PHYRM	Uncharacterized protein. (754 aa)
	H3GPS7_PHYRM	HD_domain domain-containing protein. (461 aa)
	H3GIP3_PHYRM	Uncharacterized protein; Belongs to the adenylate kinase family. (335 aa)
	H3GIF4_PHYRM	SAICAR_synt domain-containing protein. (341 aa)
	H3GHT2_PHYRM	Uncharacterized protein. (229 aa)
	H3GHL0_PHYRM	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (222 aa)
	H3GH33_PHYRM	Uncharacterized protein. (388 aa)
	H3GH24_PHYRM	PNP_UDP_1 domain-containing protein. (354 aa)
	H3GH23_PHYRM	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (315 aa)
	H3GGY7_PHYRM	Uncharacterized protein; Belongs to the adenylate kinase family. (537 aa)
	H3GGB0_PHYRM	Nudix hydrolase domain-containing protein. (254 aa)
	H3GE58_PHYRM	Thymidine kinase. (173 aa)
	H3GDX3_PHYRM	Uncharacterized protein. (700 aa)
	H3GBB8_PHYRM	Pribosyltran domain-containing protein. (189 aa)
	H3GAS9_PHYRM	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity; Belongs to the adenylate kinase family. AK6 subfamily. (174 aa)
	H3GAR8_PHYRM	Uncharacterized protein. (493 aa)
	H3GAQ0_PHYRM	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (359 aa)
	H3GAM9_PHYRM	PNP_UDP_1 domain-containing protein. (303 aa)
	H3GA88_PHYRM	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (198 aa)
	H3GA84_PHYRM	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (493 aa)
	H3GA45_PHYRM	Uncharacterized protein. (528 aa)
	H3GA16_PHYRM	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (789 aa)
	H3GA09_PHYRM	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (485 aa)
	H3G9Z9_PHYRM	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (190 aa)
	H3G9Y9_PHYRM	Amidophosphoribosyltransferase. (505 aa)
	H3G9X0_PHYRM	ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (241 aa)
	H3G9V5_PHYRM	Glutaredoxin domain-containing protein. (104 aa)
	H3G9R6_PHYRM	Thymidylate_kin domain-containing protein. (199 aa)
	H3G9N6_PHYRM	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (499 aa)
	H3G9H2_PHYRM	Uncharacterized protein. (247 aa)
	H3G9D6_PHYRM	Glutamine amidotransferase type-1 domain-containing protein. (1366 aa)
	H3G995_PHYRM	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
	H3G978_PHYRM	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (580 aa)
	H3G8X8_PHYRM	Uncharacterized protein. (345 aa)
	H3G4X3_PHYRM	AIRC domain-containing protein. (204 aa)
	H3G572_PHYRM	Uncharacterized protein. (71 aa)
	H3G5F5_PHYRM	Uncharacterized protein. (336 aa)
	H3G5G0_PHYRM	ATP-grasp domain-containing protein. (578 aa)
	H3G5G5_PHYRM	OMPdecase domain-containing protein. (428 aa)
	H3G6G8_PHYRM	ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (215 aa)
	H3G722_PHYRM	CMP/dCMP-type deaminase domain-containing protein. (165 aa)
	H3G744_PHYRM	A_deaminase domain-containing protein. (466 aa)
	H3G7E1_PHYRM	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (409 aa)
	H3G7K6_PHYRM	Uncharacterized protein. (308 aa)
	H3G863_PHYRM	MGS domain-containing protein. (616 aa)
	H3G8H8_PHYRM	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (480 aa)
	H3G8N5_PHYRM	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (362 aa)
	H3GRW0_PHYRM	Nudix hydrolase domain-containing protein. (258 aa)
	H3GU84_PHYRM	HD domain-containing protein. (586 aa)
	H3GUF2_PHYRM	Uncharacterized protein. (466 aa)
	H3GV61_PHYRM	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (565 aa)
	H3GVQ3_PHYRM	Glutaredoxin domain-containing protein. (116 aa)
	H3GVR3_PHYRM	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (579 aa)
	H3GWA2_PHYRM	Uncharacterized protein; Belongs to the Nudix hydrolase family. (368 aa)
	H3H0N0_PHYRM	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (521 aa)
	H3H1L1_PHYRM	Thioredoxin domain-containing protein. (105 aa)
	H3H1Q6_PHYRM	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (523 aa)
	H3H263_PHYRM	PPM-type phosphatase domain-containing protein. (480 aa)
	H3H2H6_PHYRM	DHO_dh domain-containing protein. (101 aa)
	H3H380_PHYRM	PNP_UDP_1 domain-containing protein. (431 aa)
	H3H3C1_PHYRM	ATP-grasp domain-containing protein. (1146 aa)
	H3H3F8_PHYRM	Uncharacterized protein. (451 aa)
	H3H479_PHYRM	Uncharacterized protein. (801 aa)
	H3H6B9_PHYRM	Nudix hydrolase domain-containing protein. (258 aa)
	H3H6L0_PHYRM	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (742 aa)
	H3H6W0_PHYRM	Uncharacterized protein. (441 aa)
	H3H9K8_PHYRM	GRIP domain-containing protein. (175 aa)
	H3HB01_PHYRM	Uncharacterized protein. (167 aa)
	H3HDU9_PHYRM	Uncharacterized protein. (120 aa)
	H3HE26_PHYRM	Uncharacterized protein. (877 aa)
	H3GIP9_PHYRM	Uncharacterized protein. (948 aa)

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3G4X3_PHYRM	H3G572_PHYRM	H3G4X3	H3G572	AIRC domain-containing protein.	Uncharacterized protein.	0.402
H3G4X3_PHYRM	H3G5G5_PHYRM	H3G4X3	H3G5G5	AIRC domain-containing protein.	OMPdecase domain-containing protein.	0.456
H3G4X3_PHYRM	H3G7E1_PHYRM	H3G4X3	H3G7E1	AIRC domain-containing protein.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.825
H3G4X3_PHYRM	H3G863_PHYRM	H3G4X3	H3G863	AIRC domain-containing protein.	MGS domain-containing protein.	0.930
H3G4X3_PHYRM	H3G8H8_PHYRM	H3G4X3	H3G8H8	AIRC domain-containing protein.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.950
H3G4X3_PHYRM	H3G8N5_PHYRM	H3G4X3	H3G8N5	AIRC domain-containing protein.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.402
H3G4X3_PHYRM	H3G978_PHYRM	H3G4X3	H3G978	AIRC domain-containing protein.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.410
H3G4X3_PHYRM	H3G9D6_PHYRM	H3G4X3	H3G9D6	AIRC domain-containing protein.	Glutamine amidotransferase type-1 domain-containing protein.	0.853
H3G4X3_PHYRM	H3G9N6_PHYRM	H3G4X3	H3G9N6	AIRC domain-containing protein.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.402
H3G4X3_PHYRM	H3G9R6_PHYRM	H3G4X3	H3G9R6	AIRC domain-containing protein.	Thymidylate_kin domain-containing protein.	0.417
H3G4X3_PHYRM	H3G9Y9_PHYRM	H3G4X3	H3G9Y9	AIRC domain-containing protein.	Amidophosphoribosyltransferase.	0.940
H3G4X3_PHYRM	H3GA45_PHYRM	H3G4X3	H3GA45	AIRC domain-containing protein.	Uncharacterized protein.	0.561
H3G4X3_PHYRM	H3GAR8_PHYRM	H3G4X3	H3GAR8	AIRC domain-containing protein.	Uncharacterized protein.	0.402
H3G4X3_PHYRM	H3GBB8_PHYRM	H3G4X3	H3GBB8	AIRC domain-containing protein.	Pribosyltran domain-containing protein.	0.510
H3G4X3_PHYRM	H3GDX3_PHYRM	H3G4X3	H3GDX3	AIRC domain-containing protein.	Uncharacterized protein.	0.853
H3G4X3_PHYRM	H3GNW5_PHYRM	H3G4X3	H3GNW5	AIRC domain-containing protein.	Uncharacterized protein.	0.853
H3G4X3_PHYRM	H3GV61_PHYRM	H3G4X3	H3GV61	AIRC domain-containing protein.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.825
H3G4X3_PHYRM	H3H3C1_PHYRM	H3G4X3	H3H3C1	AIRC domain-containing protein.	ATP-grasp domain-containing protein.	0.996
H3G4X3_PHYRM	H3H6W0_PHYRM	H3G4X3	H3H6W0	AIRC domain-containing protein.	Uncharacterized protein.	0.853
H3G572_PHYRM	H3G4X3_PHYRM	H3G572	H3G4X3	Uncharacterized protein.	AIRC domain-containing protein.	0.402

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