(54 nodes) DNA Double-Strand Break Repair network (Phytophthora ramorum)

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	H3H5C6_PHYRM	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (569 aa)
	H3H2K5_PHYRM	TIMELESS domain-containing protein. (1188 aa)
	H3H1R3_PHYRM	Uncharacterized protein. (691 aa)
	H3H1L0_PHYRM	Deacetylase sirtuin-type domain-containing protein. (380 aa)
	H3G5W3_PHYRM	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. (490 aa)
	H3GC32_PHYRM	Uncharacterized protein. (496 aa)
	H3G560_PHYRM	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (418 aa)
	H3GBD7_PHYRM	Uncharacterized protein. (641 aa)
	H3GBB3_PHYRM	Uncharacterized protein. (629 aa)
	H3GBB1_PHYRM	BRCT domain-containing protein. (825 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (392 aa)
	H3GA74_PHYRM	AAA_23 domain-containing protein. (221 aa)
	H3GA01_PHYRM	Histone H2B; Belongs to the histone H2B family. (117 aa)
	H3G9Z5_PHYRM	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	H3G9Z2_PHYRM	Histone H2B; Belongs to the histone H2B family. (115 aa)
	H3G8Y8_PHYRM	Uncharacterized protein; Belongs to the RecA family. (447 aa)
	H3G8T9_PHYRM	Ubiquitin-like domain-containing protein. (164 aa)
	H3G7Y5_PHYRM	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (628 aa)
	H3G6X5_PHYRM	Uncharacterized protein. (352 aa)
	H3G6F5_PHYRM	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (373 aa)
	H3HE46_PHYRM	RECA_2 domain-containing protein. (401 aa)
	H3H137_PHYRM	Uncharacterized protein. (106 aa)
	H3H0P8_PHYRM	Protein kinase domain-containing protein. (217 aa)
	H3GZE2_PHYRM	ERCC4 domain-containing protein. (567 aa)
	H3HE25_PHYRM	DNA_ligase_OB_2 domain-containing protein. (630 aa)
	H3HDR8_PHYRM	Uncharacterized protein. (282 aa)
	H3HDP3_PHYRM	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (840 aa)
	H3HDP1_PHYRM	Uncharacterized protein. (226 aa)
	H3HDC0_PHYRM	Uncharacterized protein. (625 aa)
	H3HDB5_PHYRM	Serine/threonine-protein phosphatase. (613 aa)
	H3HDB4_PHYRM	FHA domain-containing protein. (421 aa)
	H3HDA1_PHYRM	DNA ligase. (806 aa)
	H3HCX3_PHYRM	Uncharacterized protein. (381 aa)
	H3HCN2_PHYRM	FHA domain-containing protein. (156 aa)
	H3HC67_PHYRM	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1030 aa)
	H3HC19_PHYRM	Metallophos domain-containing protein. (497 aa)
	H3H867_PHYRM	Deacetylase sirtuin-type domain-containing protein. (281 aa)
	H3H7K0_PHYRM	3'-5' exonuclease domain-containing protein. (278 aa)
	H3H5N9_PHYRM	Uncharacterized protein. (408 aa)
	H3GXW6_PHYRM	Uncharacterized protein. (1049 aa)
	H3GV41_PHYRM	Uncharacterized protein. (1110 aa)
	H3GTA2_PHYRM	VWFA domain-containing protein. (776 aa)
	H3GRQ6_PHYRM	Uncharacterized protein. (361 aa)
	H3GQI3_PHYRM	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (529 aa)
	H3GMG2_PHYRM	Uncharacterized protein. (342 aa)
	H3GM95_PHYRM	Uncharacterized protein. (284 aa)
	H3GLA8_PHYRM	Uncharacterized protein. (139 aa)
	H3GKP3_PHYRM	Uncharacterized protein. (152 aa)
	H3GK04_PHYRM	MULE domain-containing protein. (385 aa)
	H3GI82_PHYRM	Uncharacterized protein. (492 aa)
	H3GH86_PHYRM	UmuC domain-containing protein. (675 aa)
	H3GER8_PHYRM	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (336 aa)
	H3GCR3_PHYRM	Uncharacterized protein. (817 aa)
	H3GCB9_PHYRM	Replication protein A subunit. (622 aa)

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	H3G560_PHYRM	H3GAS1	H3G560	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.871
FEN1	H3G5W3_PHYRM	H3GAS1	H3G5W3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family.	0.980
FEN1	H3G6F5_PHYRM	H3GAS1	H3G6F5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.697
FEN1	H3G6X5_PHYRM	H3GAS1	H3G6X5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.898
FEN1	H3G7Y5_PHYRM	H3GAS1	H3G7Y5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.775
FEN1	H3G8Y8_PHYRM	H3GAS1	H3G8Y8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein; Belongs to the RecA family.	0.839
FEN1	H3GA74_PHYRM	H3GAS1	H3GA74	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA_23 domain-containing protein.	0.908
FEN1	H3GBB1_PHYRM	H3GAS1	H3GBB1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	BRCT domain-containing protein.	0.576
FEN1	H3GBB3_PHYRM	H3GAS1	H3GBB3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.576
FEN1	H3GC32_PHYRM	H3GAS1	H3GC32	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.550
FEN1	H3GCB9_PHYRM	H3GAS1	H3GCB9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication protein A subunit.	0.810
FEN1	H3GCR3_PHYRM	H3GAS1	H3GCR3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.494
FEN1	H3GER8_PHYRM	H3GAS1	H3GER8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.839
FEN1	H3GH86_PHYRM	H3GAS1	H3GH86	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	UmuC domain-containing protein.	0.547
FEN1	H3GI82_PHYRM	H3GAS1	H3GI82	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.700
FEN1	H3GLA8_PHYRM	H3GAS1	H3GLA8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.839
FEN1	H3GM95_PHYRM	H3GAS1	H3GM95	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.732
FEN1	H3GMG2_PHYRM	H3GAS1	H3GMG2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.697
FEN1	H3GQI3_PHYRM	H3GAS1	H3GQI3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.871
FEN1	H3GTA2_PHYRM	H3GAS1	H3GTA2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	VWFA domain-containing protein.	0.606

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