(48 nodes) Folate biosynthesis network (Phytophthora ramorum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	H3G9L2_PHYRM	Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. (706 aa)
	H3G5Q1_PHYRM	Elp3 domain-containing protein. (336 aa)
	H3G6R7_PHYRM	Pterin-binding domain-containing protein. (437 aa)
	H3G6T3_PHYRM	Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. (123 aa)
	H3G718_PHYRM	Rhodanese domain-containing protein. (239 aa)
	H3G797_PHYRM	GTP_cyclohydroI domain-containing protein. (203 aa)
	H3G7B1_PHYRM	MoaC domain-containing protein. (156 aa)
	H3G7T9_PHYRM	Uncharacterized protein. (393 aa)
	H3G8M7_PHYRM	Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (847 aa)
	H3G8T6_PHYRM	Uncharacterized protein. (357 aa)
	H3G8T7_PHYRM	Uncharacterized protein. (364 aa)
	H3G9R5_PHYRM	Uncharacterized protein. (437 aa)
	H3GC13_PHYRM	Uncharacterized protein. (830 aa)
	H3GEI5_PHYRM	FSH1 domain-containing protein. (270 aa)
	H3GGX6_PHYRM	FSH1 domain-containing protein. (281 aa)
	H3GH04_PHYRM	Uncharacterized protein. (619 aa)
	H3GHG7_PHYRM	Mur_ligase_M domain-containing protein. (564 aa)
	H3GIE5_PHYRM	GTP_cyclohydro2 domain-containing protein. (281 aa)
	H3GJ45_PHYRM	Uncharacterized protein. (119 aa)
	H3GLE7_PHYRM	Folate gamma-glutamyl hydrolase. (318 aa)
	H3GMP9_PHYRM	FSH1 domain-containing protein. (220 aa)
	H3GMT2_PHYRM	Alkaline phosphatase. (510 aa)
	H3GMT5_PHYRM	Uncharacterized protein. (141 aa)
	H3GMU4_PHYRM	Rhodanese domain-containing protein. (532 aa)
	H3GPE8_PHYRM	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (570 aa)
	H3GQH2_PHYRM	Radical_SAM domain-containing protein. (844 aa)
	H3GQQ7_PHYRM	Glutamine amidotransferase type-1 domain-containing protein. (825 aa)
	H3GQU3_PHYRM	FSH1 domain-containing protein. (285 aa)
	H3GQU4_PHYRM	FSH1 domain-containing protein. (269 aa)
	H3GQU7_PHYRM	FSH1 domain-containing protein. (234 aa)
	H3GQU8_PHYRM	FSH1 domain-containing protein. (247 aa)
	H3GWK0_PHYRM	Uncharacterized protein. (122 aa)
	H3GWN7_PHYRM	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. (493 aa)
	H3GXU6_PHYRM	Mur_ligase_M domain-containing protein. (563 aa)
	H3GY17_PHYRM	MFS domain-containing protein. (410 aa)
	H3GZX0_PHYRM	ZT_dimer domain-containing protein. (384 aa)
	H3H2T7_PHYRM	ZT_dimer domain-containing protein. (371 aa)
	H3H3N4_PHYRM	Uncharacterized protein. (487 aa)
	H3H609_PHYRM	FSH1 domain-containing protein. (246 aa)
	H3H6Y4_PHYRM	FSH1 domain-containing protein. (140 aa)
	H3H918_PHYRM	Uncharacterized protein. (287 aa)
	H3H9V2_PHYRM	Uncharacterized protein. (103 aa)
	H3HAW9_PHYRM	Uncharacterized protein. (768 aa)
	H3HB66_PHYRM	Uncharacterized protein. (306 aa)
	H3HC90_PHYRM	FSH1 domain-containing protein. (220 aa)
	H3HCI3_PHYRM	ZT_dimer domain-containing protein. (369 aa)
	H3HCJ6_PHYRM	Rhodanese domain-containing protein. (400 aa)
	H3HDZ5_PHYRM	ZT_dimer domain-containing protein. (613 aa)

Your Current Organism:

Phytophthora ramorum

NCBI taxonomy Id: 164328
Other names: BBA 9/95, CBS 101553, CPHST BL 55G, Ex-type CPHST BL 55G, P. ramorum, Phytophthora sp. ex Parrotia persica, Sudden oak death agent, WPC P10103, ramorum blight, sudden oak death

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3G5Q1_PHYRM	H3G6T3_PHYRM	H3G5Q1	H3G6T3	Elp3 domain-containing protein.	Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.	0.930
H3G5Q1_PHYRM	H3G797_PHYRM	H3G5Q1	H3G797	Elp3 domain-containing protein.	GTP_cyclohydroI domain-containing protein.	0.607
H3G5Q1_PHYRM	H3G7B1_PHYRM	H3G5Q1	H3G7B1	Elp3 domain-containing protein.	MoaC domain-containing protein.	0.895
H3G5Q1_PHYRM	H3G8M7_PHYRM	H3G5Q1	H3G8M7	Elp3 domain-containing protein.	Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.	0.483
H3G5Q1_PHYRM	H3GPE8_PHYRM	H3G5Q1	H3GPE8	Elp3 domain-containing protein.	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.	0.912
H3G5Q1_PHYRM	H3GWK0_PHYRM	H3G5Q1	H3GWK0	Elp3 domain-containing protein.	Uncharacterized protein.	0.416
H3G5Q1_PHYRM	H3GWN7_PHYRM	H3G5Q1	H3GWN7	Elp3 domain-containing protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.631
H3G6R7_PHYRM	H3G797_PHYRM	H3G6R7	H3G797	Pterin-binding domain-containing protein.	GTP_cyclohydroI domain-containing protein.	0.974
H3G6R7_PHYRM	H3GC13_PHYRM	H3G6R7	H3GC13	Pterin-binding domain-containing protein.	Uncharacterized protein.	0.584
H3G6R7_PHYRM	H3GHG7_PHYRM	H3G6R7	H3GHG7	Pterin-binding domain-containing protein.	Mur_ligase_M domain-containing protein.	0.996
H3G6R7_PHYRM	H3GMT2_PHYRM	H3G6R7	H3GMT2	Pterin-binding domain-containing protein.	Alkaline phosphatase.	0.584
H3G6R7_PHYRM	H3GMT5_PHYRM	H3G6R7	H3GMT5	Pterin-binding domain-containing protein.	Uncharacterized protein.	0.584
H3G6R7_PHYRM	H3GQQ7_PHYRM	H3G6R7	H3GQQ7	Pterin-binding domain-containing protein.	Glutamine amidotransferase type-1 domain-containing protein.	0.817
H3G6R7_PHYRM	H3GWN7_PHYRM	H3G6R7	H3GWN7	Pterin-binding domain-containing protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.937
H3G6R7_PHYRM	H3GXU6_PHYRM	H3G6R7	H3GXU6	Pterin-binding domain-containing protein.	Mur_ligase_M domain-containing protein.	0.996
H3G6R7_PHYRM	H3HC90_PHYRM	H3G6R7	H3HC90	Pterin-binding domain-containing protein.	FSH1 domain-containing protein.	0.740
H3G6T3_PHYRM	H3G5Q1_PHYRM	H3G6T3	H3G5Q1	Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.	Elp3 domain-containing protein.	0.930
H3G6T3_PHYRM	H3G7B1_PHYRM	H3G6T3	H3G7B1	Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.	MoaC domain-containing protein.	0.899
H3G6T3_PHYRM	H3G8M7_PHYRM	H3G6T3	H3G8M7	Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.	Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.	0.440
H3G6T3_PHYRM	H3GPE8_PHYRM	H3G6T3	H3GPE8	Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.	0.989

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