STRINGSTRING
dnaE_1 dnaE_1 infB infB AKH32405.1 AKH32405.1 AKH32408.1 AKH32408.1 pth pth dnaN dnaN alaS_1 alaS_1 AKH32430.1 AKH32430.1 AKH32436.1 AKH32436.1 rplA rplA rplK rplK nusG nusG dnaC dnaC dnaE_2 dnaE_2 AKH32486.1 AKH32486.1 serS serS queA queA metG metG valS valS trpS trpS AKH32537.1 AKH32537.1 rpsO rpsO sigA_1 sigA_1 sigE sigE sigA_2 sigA_2 murAA murAA AKH32588.1 AKH32588.1 AKH32595.1 AKH32595.1 tgt tgt rpsP rpsP AKH32665.1 AKH32665.1 gmk gmk frr frr rpsT rpsT cysS cysS hisS hisS yciC yciC rpoC rpoC rpoB rpoB AKH32699.1 AKH32699.1 AKH32700.1 AKH32700.1 rpsF rpsF tsf tsf rpsB rpsB rplL rplL rplJ rplJ AKH32717.1 AKH32717.1 AKH32719.1 AKH32719.1 pyrG pyrG rpmB rpmB rplY rplY rplS rplS rpsG rpsG rpsL rpsL AKH32738.1 AKH32738.1 atpG atpG AKH32740.1 AKH32740.1 AKH32742.1 AKH32742.1 atpA atpA atpD atpD rpmA rpmA rpmF rpmF AKH32749.1 AKH32749.1 smpB smpB argS argS infC infC rpmI rpmI rplT rplT rplU rplU infA infA AKH32781.1 AKH32781.1 rpsM rpsM rpsK rpsK rpsD rpsD rpoA rpoA AKH32786.1 AKH32786.1 rplM rplM rpsI rpsI cmk cmk adk_1 adk_1 tuf tuf rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsN1 rpsN1 rpsH rpsH rplF rplF rplR rplR rpsE rpsE rplO rplO nrdB nrdB adk_2 adk_2 def def priA priA gltX gltX thrS thrS yhhQ yhhQ rplI rplI AKH32971.1 AKH32971.1 ndk ndk udk udk glyQS glyQS gatA gatA efp efp AKH33008.1 AKH33008.1 aspS aspS lysS lysS proS proS pheT pheT alaS_2 alaS_2 folD folD gatB gatB AKH33142.1 AKH33142.1 lepA lepA asnS asnS hemN hemN pyrH pyrH dnaX dnaX AKH33197.1 AKH33197.1 pncB pncB nadE nadE nadR nadR leuS leuS tyrS tyrS ylaC ylaC dhfrIII dhfrIII thyA_1 thyA_1 AKH33326.1 AKH33326.1 dfrA dfrA thyA_2 thyA_2 tmk tmk fusA fusA pheS pheS dnaG dnaG prfA prfA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dnaE_1DNA polymerase III subunit alpha. (998 aa)
infBTranslation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (775 aa)
AKH32405.1Reverse transcriptase (RNA-dependent DNA polymerase). (518 aa)
AKH32408.1Hypothetical protein. (95 aa)
pthPeptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (178 aa)
dnaNDNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (378 aa)
alaS_1Alanine--tRNA ligase. (530 aa)
AKH32430.1Hypothetical protein. (144 aa)
AKH32436.1Hypothetical protein. (144 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (226 aa)
rplK50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (146 aa)
nusGHypothetical protein; Participates in transcription elongation, termination and antitermination. (192 aa)
dnaCReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (454 aa)
dnaE_2DNA polymerase III subunit alpha. (315 aa)
AKH32486.1Hypothetical protein. (666 aa)
serSSerine--tRNA ligase. (423 aa)
queAS-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (398 aa)
metGMethionine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (515 aa)
valSValine--tRNA ligase. (807 aa)
trpSTryptophan--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (358 aa)
AKH32537.130S ribosomal protein S1 homolog. (363 aa)
rpsO30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (99 aa)
sigA_1RNA polymerase sigma factor SigA; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (404 aa)
sigERNA polymerase sigma-E factor precursor; Belongs to the sigma-70 factor family. ECF subfamily. (190 aa)
sigA_2RNA polymerase sigma factor SigA. (380 aa)
murAAUDP-N-acetylglucosamine 1-carboxyvinyltransferase 1. (429 aa)
AKH32588.1Putative 3'-5' exonuclease related to the exonuclease domain of PolB. (214 aa)
AKH32595.1valyl-tRNA synthetase. (907 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (381 aa)
rpsP30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (100 aa)
AKH32665.1DNA polymerase III subunit delta. (327 aa)
gmkGuanylate kinase. (195 aa)
frrRibosome-recycling factor. (179 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (87 aa)
cysSCysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (441 aa)
hisSHistidine--tRNA ligase. (421 aa)
yciCPutative metal chaperone YciC. (381 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1284 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1200 aa)
AKH32699.150S ribosomal protein L34. (60 aa)
AKH32700.130S ribosomal protein S18. (69 aa)
rpsF30S ribosomal protein S6. (125 aa)
tsfElongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (263 aa)
rpsB30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (219 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (127 aa)
rplJ50S ribosomal protein L10. (171 aa)
AKH32717.1Hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (259 aa)
AKH32719.1Hypothetical protein. (198 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (528 aa)
rpmB50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (63 aa)
rplY50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (197 aa)
rplS50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (163 aa)
rpsG30S ribosomal protein S7. (154 aa)
rpsL30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (138 aa)
AKH32738.1Hypothetical protein. (88 aa)
atpGATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (295 aa)
AKH32740.1F0F1 ATP synthase subunit A. (267 aa)
AKH32742.1Hypothetical protein. (167 aa)
atpAATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (502 aa)
atpDATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (465 aa)
rpmA50S ribosomal protein L27. (93 aa)
rpmF50S ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (76 aa)
AKH32749.1Transcription antitermination protein NusB. (164 aa)
smpBSsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (154 aa)
argSArginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (576 aa)
infCTranslation initiation factor IF-3; Belongs to the IF-3 family. (223 aa)
rpmI50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (115 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (105 aa)
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (97 aa)
AKH32781.150S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (43 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (120 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (131 aa)
rpsD30S ribosomal protein S4. (206 aa)
rpoADNA-directed RNA polymerase subunit alpha. (334 aa)
AKH32786.150S ribosomal protein L17. (129 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (158 aa)
rpsI30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (137 aa)
cmkCytidylate kinase. (226 aa)
adk_1Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (191 aa)
tufElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (390 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (112 aa)
rplC50S ribosomal protein L3. (192 aa)
rplD50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (212 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (113 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (283 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (85 aa)
rplV50S ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (110 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (227 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (139 aa)
rpmC50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (74 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal. (86 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (124 aa)
rplX50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (97 aa)
rplE50S ribosomal protein L5; Belongs to the universal ribosomal protein uL5 family. (179 aa)
rpsN130S ribosomal protein S14. (75 aa)
rpsH30S ribosomal protein S8; Belongs to the universal ribosomal protein uS8 family. (133 aa)
rplF50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. (181 aa)
rplR50S ribosomal protein L18. (114 aa)
rpsE30S ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family. (203 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (148 aa)
nrdBRibonucleoside-diphosphate reductase subunit beta. (321 aa)
adk_2Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
defPeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (174 aa)
priAPrimosomal protein N'. (345 aa)
gltXGlutamate--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (546 aa)
thrSThreonine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. (628 aa)
yhhQInner membrane protein YhhQ; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (226 aa)
rplI50S ribosomal protein L9. (181 aa)
AKH32971.150S ribosomal protein L31. (77 aa)
ndkNucleoside diphosphate kinase; Belongs to the NDK family. (167 aa)
udkUridine kinase. (357 aa)
glyQSGlycine--tRNA ligase. (481 aa)
gatAGlutamyl-tRNA(Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (462 aa)
efpElongation factor P. (183 aa)
AKH33008.1Hypothetical protein; Transcription termination/antitermination protein NusA. (342 aa)
aspSAspartate--tRNA ligase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (585 aa)
lysSLysine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. (557 aa)
proSProline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (509 aa)
pheTPhenylalanine--tRNA ligase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (845 aa)
alaS_2Alanine--tRNA ligase. (308 aa)
folDBifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
gatBAspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (478 aa)
AKH33142.1DNA polymerase III subunit delta'. (256 aa)
lepAElongation factor 4; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (657 aa)
asnSAsparagine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. (431 aa)
hemNOxygen-independent coproporphyrinogen-III oxidase 1. (453 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (231 aa)
dnaXDNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (483 aa)
AKH33197.1Nicotinamide-nucleotide adenylyltransferase. (320 aa)
pncBNicotinate phosphoribosyltransferase; Belongs to the NAPRTase family. (452 aa)
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (271 aa)
nadRTrifunctional NAD biosynthesis/regulator protein NadR. (374 aa)
leuSLeucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (817 aa)
tyrSTyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (430 aa)
ylaCRNA polymerase sigma factor YlaC; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa)
dhfrIIIDihydrofolate reductase type 3. (184 aa)
thyA_1Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
AKH33326.1Hypothetical protein. (92 aa)
dfrADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (165 aa)
thyA_2Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (288 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (207 aa)
fusAElongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (705 aa)
pheSPhenylalanine--tRNA ligase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (343 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (497 aa)
prfAPeptide chain release factor 1. (356 aa)
Your Current Organism:
candidate division SR1 bacterium AalborgAAW1
NCBI taxonomy Id: 1643353
Other names: c. division SR1 bacterium Aalborg_AAW-1, candidate division SR1 bacterium Aalborg_AAW-1
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