(25 nodes) Mismatch repair network (Thermokryptus mobilis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	JGI1_01775	Unannotated protein. (662 aa)
	JGI1_00049	Unannotated protein. (566 aa)
	JGI1_00104	Unannotated protein. (388 aa)
	dnaX	Unannotated protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (561 aa)
	JGI1_00398	Unannotated protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication [...] (379 aa)
	mutL	Unannotated protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (609 aa)
	xseB	Unannotated protein; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (87 aa)
	JGI1_02277	Unannotated protein. (662 aa)
	xseA	Unannotated protein; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (411 aa)
	JGI1_00622	Unannotated protein. (234 aa)
	JGI1_00664	Unannotated protein; Represses a number of genes involved in the response to DNA damage (SOS response). (206 aa)
	JGI1_00811	Unannotated protein. (149 aa)
	JGI1_00855	Unannotated protein. (200 aa)
	ligA	Unannotated protein; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (670 aa)
	JGI1_01030	Unannotated protein. (200 aa)
	JGI1_01195	Unannotated protein. (714 aa)
	JGI1_01848	Unannotated protein. (702 aa)
	JGI1_01272	Unannotated protein. (602 aa)
	JGI1_02318	Unannotated protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (169 aa)
	JGI1_01458	Unannotated protein. (254 aa)
	JGI1_01459	Unannotated protein. (92 aa)
	JGI1_01591	Unannotated protein. (1160 aa)
	JGI1_01617	Unannotated protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (163 aa)
	mutS2	Unannotated protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (781 aa)
	JGI1_01773	Unannotated protein. (426 aa)

Your Current Organism:

Thermokryptus mobilis

NCBI taxonomy Id: 1643428
Other names: C. Thermokryptus mobilis, Candidatus Thermokryptus mobilis, bacterium JGI-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
JGI1_00049	JGI1_00398	GCA_001442855_00046	GCA_001442855_00385	Unannotated protein.	Unannotated protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication [...]	0.439
JGI1_00049	JGI1_00811	GCA_001442855_00046	GCA_001442855_00790	Unannotated protein.	Unannotated protein.	0.415
JGI1_00049	JGI1_01617	GCA_001442855_00046	GCA_001442855_01582	Unannotated protein.	Unannotated protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.415
JGI1_00049	mutL	GCA_001442855_00046	GCA_001442855_00396	Unannotated protein.	Unannotated protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	0.414
JGI1_00049	xseA	GCA_001442855_00046	GCA_001442855_00405	Unannotated protein.	Unannotated protein; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family.	0.448
JGI1_00049	xseB	GCA_001442855_00046	GCA_001442855_00404	Unannotated protein.	Unannotated protein; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family.	0.406
JGI1_00104	JGI1_00398	GCA_001442855_00098	GCA_001442855_00385	Unannotated protein.	Unannotated protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication [...]	0.989
JGI1_00104	JGI1_00811	GCA_001442855_00098	GCA_001442855_00790	Unannotated protein.	Unannotated protein.	0.944
JGI1_00104	JGI1_00855	GCA_001442855_00098	GCA_001442855_00832	Unannotated protein.	Unannotated protein.	0.981
JGI1_00104	JGI1_01458	GCA_001442855_00098	GCA_001442855_01427	Unannotated protein.	Unannotated protein.	0.989
JGI1_00104	JGI1_01459	GCA_001442855_00098	GCA_001442855_01428	Unannotated protein.	Unannotated protein.	0.979
JGI1_00104	JGI1_01591	GCA_001442855_00098	GCA_001442855_01557	Unannotated protein.	Unannotated protein.	0.988
JGI1_00104	JGI1_01617	GCA_001442855_00098	GCA_001442855_01582	Unannotated protein.	Unannotated protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.944
JGI1_00104	dnaX	GCA_001442855_00098	GCA_001442855_00207	Unannotated protein.	Unannotated protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.523
JGI1_00104	ligA	GCA_001442855_00098	GCA_001442855_00846	Unannotated protein.	Unannotated protein; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.	0.645
JGI1_00104	mutL	GCA_001442855_00098	GCA_001442855_00396	Unannotated protein.	Unannotated protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	0.452
JGI1_00398	JGI1_00049	GCA_001442855_00385	GCA_001442855_00046	Unannotated protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication [...]	Unannotated protein.	0.439
JGI1_00398	JGI1_00104	GCA_001442855_00385	GCA_001442855_00098	Unannotated protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication [...]	Unannotated protein.	0.989
JGI1_00398	JGI1_00622	GCA_001442855_00385	GCA_001442855_00605	Unannotated protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication [...]	Unannotated protein.	0.996
JGI1_00398	JGI1_00811	GCA_001442855_00385	GCA_001442855_00790	Unannotated protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication [...]	Unannotated protein.	0.486