STRINGSTRING
AOR29761.1 AOR29761.1 AOR29943.1 AOR29943.1 AOR29950.1 AOR29950.1 AOR29996.1 AOR29996.1 AOR30030.1 AOR30030.1 AOR36818.1 AOR36818.1 AOR30190.1 AOR30190.1 AOR36875.1 AOR36875.1 AOR30356.1 AOR30356.1 AOR30357.1 AOR30357.1 AOR36886.1 AOR36886.1 AOR30431.1 AOR30431.1 AOR30444.1 AOR30444.1 AOR30445.1 AOR30445.1 AOR30458.1 AOR30458.1 sdhA sdhA AOR30460.1 AOR30460.1 AOR30562.1 AOR30562.1 AOR36907.1 AOR36907.1 AOR30631.1 AOR30631.1 AOR36919.1 AOR36919.1 AOR30896.1 AOR30896.1 AOR31132.1 AOR31132.1 AOR31200.1 AOR31200.1 AOR31249.1 AOR31249.1 AOR31382.1 AOR31382.1 AOR31402.1 AOR31402.1 AOR31440.1 AOR31440.1 AOR37026.1 AOR37026.1 AOR31674.1 AOR31674.1 AOR31675.1 AOR31675.1 BFF78_12725 BFF78_12725 leuD leuD leuC leuC AOR31919.1 AOR31919.1 AOR31926.1 AOR31926.1 leuB leuB ilvC ilvC AOR31934.1 AOR31934.1 AOR31935.1 AOR31935.1 gcvT gcvT gcvH gcvH glyA glyA AOR31983.1 AOR31983.1 kgd kgd AOR32127.1 AOR32127.1 AOR32289.1 AOR32289.1 AOR32290.1 AOR32290.1 AOR32291.1 AOR32291.1 AOR32292.1 AOR32292.1 AOR32293.1 AOR32293.1 AOR32294.1 AOR32294.1 AOR32301.1 AOR32301.1 AOR32348.1 AOR32348.1 aspA aspA pckG pckG AOR32484.1 AOR32484.1 AOR32485.1 AOR32485.1 AOR32486.1 AOR32486.1 AOR32487.1 AOR32487.1 mdh mdh sucD sucD sucC sucC gabD2 gabD2 AOR37145.1 AOR37145.1 AOR32683.1 AOR32683.1 AOR32684.1 AOR32684.1 ilvD ilvD AOR33090.1 AOR33090.1 AOR33195.1 AOR33195.1 AOR33196.1 AOR33196.1 AOR33197.1 AOR33197.1 AOR33204.1 AOR33204.1 AOR33205.1 AOR33205.1 AOR33206.1 AOR33206.1 AOR33665.1 AOR33665.1 AOR37273.1 AOR37273.1 ppc ppc AOR34154.1 AOR34154.1 AOR34180.1 AOR34180.1 leuA leuA AOR34477.1 AOR34477.1 AOR34580.1 AOR34580.1 lipA lipA lipB lipB BFF78_30265 BFF78_30265 AOR34768.1 AOR34768.1 AOR34769.1 AOR34769.1 AOR34902.1 AOR34902.1 gltD gltD AOR35042.1 AOR35042.1 AOR35051.1 AOR35051.1 AOR35393.1 AOR35393.1 gcvP gcvP AOR35695.1 AOR35695.1 BFF78_37305 BFF78_37305 AOR36283.1 AOR36283.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AOR29761.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
AOR29943.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (583 aa)
AOR29950.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (61 aa)
AOR29996.1Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
AOR30030.1Polysaccharide pyruvyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
AOR36818.1FAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
AOR30190.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1124 aa)
AOR36875.1Fe-S oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
AOR30356.1Iron-sulfur cluster-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
AOR30357.1Lactate utilization protein B/C; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
AOR36886.1Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
AOR30431.1Benzaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (478 aa)
AOR30444.1Fumarate hydratase, class II; Derived by automated computational analysis using gene prediction method: Protein Homology. (493 aa)
AOR30445.1Malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology. (557 aa)
AOR30458.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (649 aa)
AOR30460.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
AOR30562.1Acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (563 aa)
AOR36907.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
AOR30631.1Isocitrate dehydrogenase (NADP(+)); Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (739 aa)
AOR36919.1Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (394 aa)
AOR30896.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (514 aa)
AOR31132.1Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (597 aa)
AOR31200.1Lipoate--protein ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
AOR31249.1Fumarylacetoacetate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
AOR31382.1Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (580 aa)
AOR31402.1Phosphonomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
AOR31440.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
AOR37026.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
AOR31674.1Citrate synthase/methylcitrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (388 aa)
AOR31675.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
BFF78_12725ATP/GTP-binding protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa)
AOR31919.1Citramalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (536 aa)
AOR31926.1Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (347 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
AOR31934.1Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa)
AOR31935.1Acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (617 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (375 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
AOR31983.12-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
kgdAlpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (1267 aa)
AOR32127.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
AOR32289.1GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology. (635 aa)
AOR32290.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (767 aa)
AOR32291.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (96 aa)
AOR32292.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
AOR32293.1Fumarate reductase/succinate dehydrogenase flavoprotein subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (645 aa)
AOR32294.1Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
AOR32301.1Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
AOR32348.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (564 aa)
aspAAspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (605 aa)
AOR32484.1Succinate dehydrogenase, cytochrome b556 subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
AOR32485.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
AOR32486.1Succinate dehydrogenase flavoprotein subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (584 aa)
AOR32487.1Succinate dehydrogenase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
mdhMFS transporter; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
sucDsuccinate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
sucCsuccinate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (392 aa)
gabD2NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (537 aa)
AOR37145.1NAD-dependent dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
AOR32683.12-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (642 aa)
AOR32684.12-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
ilvDDihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (617 aa)
AOR33090.1Fe-S oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (755 aa)
AOR33195.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
AOR33196.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AOR33197.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
AOR33204.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
AOR33205.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
AOR33206.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
AOR33665.1Dimethylmenaquinone methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (961 aa)
AOR37273.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (366 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (910 aa)
AOR34154.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (561 aa)
AOR34180.1Citrate (Si)-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (429 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa)
AOR34477.1Pyruvate, phosphate dikinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (906 aa)
AOR34580.1Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (329 aa)
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (265 aa)
BFF78_30265Cellulose-binding protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
AOR34768.12-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (585 aa)
AOR34769.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
AOR34902.1Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1502 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa)
AOR35042.1Dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (577 aa)
AOR35051.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa)
AOR35393.14-amino-4-deoxychorismate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
gcvPGlycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
AOR35695.1NADP-dependent succinic semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
BFF78_37305Metallophosphoesterase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (80 aa)
AOR36283.1Serine/threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
Your Current Organism:
Streptomyces puniciscabiei
NCBI taxonomy Id: 164348
Other names: KACC 20253, LMG 21391, LMG:21391, S. puniciscabiei, Streptomyces puniciscabiei Park et al. 2003, Streptomyces sp. S77, strain S77
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